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- W2914595462 abstract "Abstract Small heat shock proteins (sHsps) are molecular chaperones employed to interact with a diverse range of substrates as the first line of defense against cellular protein aggregation. The N‐terminal region (NTR) is implicated in defining features of sHsps; notably in their ability to form dynamic and polydisperse oligomers, and chaperone activity. The physiological relevance of oligomerization and chemical‐scale mode(s) of chaperone function remain undefined. We present novel chemical tools to investigate chaperone activity and substrate specificity of human HspB1 (B1NTR), through isolation of B1NTR and development of peptide‐conjugated gold nanoparticles (AuNPs). We demonstrate that B1NTR exhibits chaperone capacity for some substrates, determined by anti‐aggregation assays and size‐exclusion chromatography. The importance of protein dynamics and multivalency on chaperone capacity was investigated using B1NTR‐conjugated AuNPs, which exhibit concentration‐dependent chaperone activity for some substrates. Our results implicate sHsp NTRs in chaperone activity, and demonstrate the therapeutic potential of sHsp‐AuNPs in rescuing aberrant protein aggregation." @default.
- W2914595462 created "2019-02-21" @default.
- W2914595462 creator A5002564977 @default.
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- W2914595462 creator A5056086627 @default.
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- W2914595462 date "2019-02-07" @default.
- W2914595462 modified "2023-09-26" @default.
- W2914595462 title "Chaperone‐like activity of the N‐terminal region of a human small heat shock protein and chaperone‐functionalized nanoparticles" @default.
- W2914595462 cites W1585736644 @default.
- W2914595462 cites W1590407931 @default.
- W2914595462 cites W1628548055 @default.
- W2914595462 cites W1822372593 @default.
- W2914595462 cites W1868485901 @default.
- W2914595462 cites W1942200014 @default.
- W2914595462 cites W1950643791 @default.
- W2914595462 cites W1964298460 @default.
- W2914595462 cites W1965650017 @default.
- W2914595462 cites W1972380090 @default.
- W2914595462 cites W197339422 @default.
- W2914595462 cites W1981542877 @default.
- W2914595462 cites W1982715618 @default.
- W2914595462 cites W1983790438 @default.
- W2914595462 cites W1986505227 @default.
- W2914595462 cites W1988371819 @default.
- W2914595462 cites W1993718695 @default.
- W2914595462 cites W2003149545 @default.
- W2914595462 cites W2003503651 @default.
- W2914595462 cites W2005217783 @default.
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- W2914595462 cites W2024079970 @default.
- W2914595462 cites W2025493128 @default.
- W2914595462 cites W2028775235 @default.
- W2914595462 cites W2030591915 @default.
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- W2914595462 cites W2048141156 @default.
- W2914595462 cites W2049823839 @default.
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- W2914595462 cites W2085372239 @default.
- W2914595462 cites W2086910133 @default.
- W2914595462 cites W2087713518 @default.
- W2914595462 cites W2096733402 @default.
- W2914595462 cites W2098555753 @default.
- W2914595462 cites W2100479149 @default.
- W2914595462 cites W2101476524 @default.
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- W2914595462 cites W2128064586 @default.
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- W2914595462 cites W2156343873 @default.
- W2914595462 cites W2161104171 @default.
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- W2914595462 cites W2212687024 @default.
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- W2914595462 cites W2323132266 @default.
- W2914595462 cites W2329418775 @default.
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- W2914595462 cites W2613815235 @default.
- W2914595462 cites W2765928659 @default.
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- W2914595462 doi "https://doi.org/10.1002/prot.25662" @default.
- W2914595462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6607909" @default.
- W2914595462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30684363" @default.
- W2914595462 hasPublicationYear "2019" @default.
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