Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914598045> ?p ?o ?g. }
- W2914598045 abstract "The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or activation of REV-ERB with synthetic agonists inhibits the replication of HCV and the related flaviruses dengue and Zika via perturbation of lipid signaling pathways. This study highlights a role for the circadian clock component REV-ERBα in regulating flavivirus replication." @default.
- W2914598045 created "2019-02-21" @default.
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- W2914598045 date "2019-01-22" @default.
- W2914598045 modified "2023-10-01" @default.
- W2914598045 title "The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication" @default.
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- W2914598045 cites W1975191711 @default.
- W2914598045 cites W1976471753 @default.
- W2914598045 cites W1977709885 @default.
- W2914598045 cites W1986944906 @default.
- W2914598045 cites W1988024135 @default.
- W2914598045 cites W1990356462 @default.
- W2914598045 cites W1998373476 @default.
- W2914598045 cites W2010445256 @default.
- W2914598045 cites W2010598858 @default.
- W2914598045 cites W2011072921 @default.
- W2914598045 cites W2012420380 @default.
- W2914598045 cites W2013314496 @default.
- W2914598045 cites W2026051181 @default.
- W2914598045 cites W2040539524 @default.
- W2914598045 cites W2052930713 @default.
- W2914598045 cites W2059148293 @default.
- W2914598045 cites W2070698569 @default.
- W2914598045 cites W2077050067 @default.
- W2914598045 cites W2077483301 @default.
- W2914598045 cites W2091531174 @default.
- W2914598045 cites W2096922519 @default.
- W2914598045 cites W2099473567 @default.
- W2914598045 cites W2107095788 @default.
- W2914598045 cites W2110256992 @default.
- W2914598045 cites W2117131162 @default.
- W2914598045 cites W2127970706 @default.
- W2914598045 cites W2129743974 @default.
- W2914598045 cites W2131222241 @default.
- W2914598045 cites W2132046473 @default.
- W2914598045 cites W2139342290 @default.
- W2914598045 cites W2161239900 @default.
- W2914598045 cites W2162423616 @default.
- W2914598045 cites W2168526937 @default.
- W2914598045 cites W2180986577 @default.
- W2914598045 cites W2255669904 @default.
- W2914598045 cites W2258645079 @default.
- W2914598045 cites W2344854262 @default.
- W2914598045 cites W2345638947 @default.
- W2914598045 cites W2468119438 @default.
- W2914598045 cites W2471905513 @default.
- W2914598045 cites W2512516821 @default.
- W2914598045 cites W2514109948 @default.
- W2914598045 cites W2528427336 @default.
- W2914598045 cites W2536252358 @default.
- W2914598045 cites W2549717874 @default.
- W2914598045 cites W2553620452 @default.
- W2914598045 cites W2557605785 @default.
- W2914598045 cites W2570545046 @default.
- W2914598045 cites W2753633070 @default.
- W2914598045 cites W2755250741 @default.
- W2914598045 cites W2756558411 @default.
- W2914598045 cites W2756877246 @default.
- W2914598045 cites W2762528019 @default.
- W2914598045 cites W2766130600 @default.
- W2914598045 cites W2775798617 @default.
- W2914598045 cites W2793690257 @default.
- W2914598045 cites W2793930217 @default.
- W2914598045 cites W2806583121 @default.
- W2914598045 cites W2886687190 @default.
- W2914598045 cites W2887608365 @default.
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- W2914598045 doi "https://doi.org/10.1038/s41467-019-08299-7" @default.
- W2914598045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6343007" @default.
- W2914598045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30670689" @default.
- W2914598045 hasPublicationYear "2019" @default.