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- W2914598380 abstract "This chapter will describe the evaluation process of a potential cosmeceutical compound prior to commercial release. The first stage of testing involves the safety and efficacy of the compound in vitro. In a cultured (most often human) cell culture model, ex vivo skin explant or full thickness skin equivalent model the compound undergoes testing for cell toxicity/viability, cell function, gene expression and protein production. Using this data the evaluation would proceed to in vivo testing in either an animal model or human trial. The tenets for a good clinical trial will be discussed including, sample size, determining successes/endpoints, proper controls and timing of metrics. A brief discussion of the most common endpoints/metrics (imaging and image analysis; expert grader/assessment and related scales; and subject self-evaluation techniques) will conclude the chapter." @default.
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- W2914598380 date "2013-11-22" @default.
- W2914598380 modified "2023-10-14" @default.
- W2914598380 title "Evaluating Cosmeceuticals" @default.
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- W2914598380 doi "https://doi.org/10.1002/9781118384824.ch3" @default.
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