Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914603453> ?p ?o ?g. }
- W2914603453 endingPage "781" @default.
- W2914603453 startingPage "772" @default.
- W2914603453 abstract "Rapid (nongenomic) membrane-initiated androgen actions have been described in nuclear androgen receptor–null cells. Four distinct proteins have been proposed as membrane androgen receptors (mARs) or sensors. Transient receptor potential melastatin 8 (TRPM8) is a calcium channel that acts as a pain receptor and mediates androgen- and menthol-induced increases in calcium levels and survival of prostate cancer cells. Testosterone (T) directly interacts with TRPM8, but extensive androgen receptor binding studies to confirm its role as an mAR are lacking. Oxoeicosanoid receptor 1 (OXER1) is highly expressed in prostate cancer tissues, and its major ligand, 5-oxoeicosatretraenoic acid (5-oxo-ETE), is a potent inducer of prostate cancer cell proliferation and survival. T competes for 5-oxo-ETE binding to OXER1 and antagonizes 5-oxo-ETE–mediated inhibition of cAMP production. However, OXER1 does not meet a traditional criterion for its designation as an mAR because T treatment alone does not alter cAMP signaling. GPRC6A is a class C G protein–coupled receptor activated by l-α-amino acids and is modulated by calcium. Although there has been controversy over the proposed role of T as a GPRC6A ligand, androgen induction of GPRC6A signaling has recently been confirmed by several researchers. ZIP9 belongs to the zinc transporter ZIP (SLC39A) family and displays specific T binding characteristic of an mAR. ZIP9 mediates androgen-dependent intracellular signaling and apoptosis of breast and prostate cancer cells through activation of G proteins. Androgen-signaling functions of ZIP9 have been confirmed in other cells, but the overall importance of ZIP9 in androgen physiology remains unclear. Here, the current status of these four proteins as mARs or sensors is critically reviewed." @default.
- W2914603453 created "2019-02-21" @default.
- W2914603453 creator A5029049466 @default.
- W2914603453 date "2019-02-11" @default.
- W2914603453 modified "2023-10-05" @default.
- W2914603453 title "Membrane Androgen Receptors Unrelated to Nuclear Steroid Receptors" @default.
- W2914603453 cites W1037307294 @default.
- W2914603453 cites W1527938810 @default.
- W2914603453 cites W1565310864 @default.
- W2914603453 cites W1576763630 @default.
- W2914603453 cites W1654089893 @default.
- W2914603453 cites W1964603052 @default.
- W2914603453 cites W1965781391 @default.
- W2914603453 cites W1970833195 @default.
- W2914603453 cites W1971352570 @default.
- W2914603453 cites W1971532261 @default.
- W2914603453 cites W1974087640 @default.
- W2914603453 cites W1981467972 @default.
- W2914603453 cites W1982029559 @default.
- W2914603453 cites W1984638038 @default.
- W2914603453 cites W1985453907 @default.
- W2914603453 cites W1990367576 @default.
- W2914603453 cites W1991920041 @default.
- W2914603453 cites W1995312949 @default.
- W2914603453 cites W1995330222 @default.
- W2914603453 cites W2008171352 @default.
- W2914603453 cites W2016122949 @default.
- W2914603453 cites W2016421933 @default.
- W2914603453 cites W2020708527 @default.
- W2914603453 cites W2021785883 @default.
- W2914603453 cites W2035716637 @default.
- W2914603453 cites W2038696594 @default.
- W2914603453 cites W2039716262 @default.
- W2914603453 cites W2039869705 @default.
- W2914603453 cites W2041286150 @default.
- W2914603453 cites W2051121822 @default.
- W2914603453 cites W2052348281 @default.
- W2914603453 cites W2064746517 @default.
- W2914603453 cites W2065274800 @default.
- W2914603453 cites W2070167771 @default.
- W2914603453 cites W2070559228 @default.
- W2914603453 cites W2072513065 @default.
- W2914603453 cites W2073221425 @default.
- W2914603453 cites W2074269446 @default.
- W2914603453 cites W2075443461 @default.
- W2914603453 cites W2077221155 @default.
- W2914603453 cites W2083353518 @default.
- W2914603453 cites W2083517169 @default.
- W2914603453 cites W2085029013 @default.
- W2914603453 cites W2085292645 @default.
- W2914603453 cites W2086065797 @default.
- W2914603453 cites W2087450123 @default.
- W2914603453 cites W2089531185 @default.
- W2914603453 cites W2091823241 @default.
- W2914603453 cites W2092893542 @default.
- W2914603453 cites W2095738477 @default.
- W2914603453 cites W2098963564 @default.
- W2914603453 cites W2102807893 @default.
- W2914603453 cites W2104259759 @default.
- W2914603453 cites W2107057154 @default.
- W2914603453 cites W2108050749 @default.
- W2914603453 cites W2117648759 @default.
- W2914603453 cites W2120222884 @default.
- W2914603453 cites W2120535739 @default.
- W2914603453 cites W2122015809 @default.
- W2914603453 cites W2125166909 @default.
- W2914603453 cites W2132960194 @default.
- W2914603453 cites W2134968208 @default.
- W2914603453 cites W2137889099 @default.
- W2914603453 cites W2144573936 @default.
- W2914603453 cites W2154818098 @default.
- W2914603453 cites W2156326987 @default.
- W2914603453 cites W2157810907 @default.
- W2914603453 cites W2163580244 @default.
- W2914603453 cites W2171253109 @default.
- W2914603453 cites W2174903051 @default.
- W2914603453 cites W2174940789 @default.
- W2914603453 cites W2214767553 @default.
- W2914603453 cites W2346327686 @default.
- W2914603453 cites W2395556395 @default.
- W2914603453 cites W2423681796 @default.
- W2914603453 cites W2525458025 @default.
- W2914603453 cites W2536015639 @default.
- W2914603453 cites W2559771495 @default.
- W2914603453 cites W2590645778 @default.
- W2914603453 cites W2611248293 @default.
- W2914603453 cites W2624670191 @default.
- W2914603453 cites W2722231853 @default.
- W2914603453 cites W2733906300 @default.
- W2914603453 cites W2755969298 @default.
- W2914603453 cites W2758269687 @default.
- W2914603453 cites W2769232638 @default.
- W2914603453 cites W2769504061 @default.
- W2914603453 cites W2790533001 @default.
- W2914603453 cites W2804856217 @default.
- W2914603453 cites W2808835917 @default.
- W2914603453 cites W2884850700 @default.
- W2914603453 cites W2890583861 @default.