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• W2914608506 endingPage "1696" @default.
• W2914608506 startingPage "1685" @default.
• W2914608506 abstract "Non-Hodgkin's lymphomas (NHLs) account for 85% of lymphomas, which are characterized by high-degree malignancy, rapid progress, and even invasion into central nervous system in pediatric patients. Although the cure rate of pediatric NHL has improved, some patients have still underwent recurrence or death. This study focuses on the effects and mechanism of forskolin on the progression of NHL, aiming to find efficient therapy methods for pediatric NHL.MTT, flow cytometry and mice tumor bearing experiments were used to evaluate the effects of forskolin on NHL cell proliferation, apoptosis and tumorigenesis. Western blotting and RT-PCR assays were used to detect protein and mRNA expression. Immunohistochemistry technology was recruited to analyze Ki-67 expression in tumor tissues.Forskolin significantly increased the expression of cleaved caspase-3/9 in both NHL Toledo and NK-92 cell lines, and inhibited cell growth. Besides, forskolin obviously reduced the expression of β-catenin protein, promoted its ubiquitination, enhanced its transportation from nuclear to cytoplasm, as well as decreased the expression of its downstream oncogenes c-myc and cyclin D1 through upregulating Axin expression and stability and inhibiting Axin ubiquitination. Moreover, forskolin enhanced the effects of SP600125, an inhibitor of c-Jun N-terminal kinase signaling on cell apoptosis promotion and tumorigenesis inhibition via Axin-induced β-catenin signaling repression.The current study clarifies that forskolin can inhibit the progression of NHL through Axin-mediated inhibition of β-catenin signaling. Moreover, forskolin improves the effects of SP600125 on cell apoptosis enhancement and tumorigenesis inhibition of NHL cells. These findings provide theoretical foundation of serving forskolin as a new effective therapeutic drug for pediatric NHL." @default.
• W2914608506 created "2019-02-21" @default.
• W2914608506 creator A5035586526 @default.
• W2914608506 creator A5035904172 @default.
• W2914608506 creator A5035952891 @default.
• W2914608506 date "2019-02-01" @default.
• W2914608506 modified "2023-10-18" @default.
• W2914608506 title "<p>Forskolin exerts anticancer roles in non-Hodgkin&rsquo;s lymphomas via regulating Axin/&beta;-catenin signaling pathway</p>" @default.
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• W2914608506 doi "https://doi.org/10.2147/cmar.s180754" @default.
• W2914608506 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6388987" @default.
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• W2914608506 hasPublicationYear "2019" @default.
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