FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914627449> ?p ?o ?g. }

• W2914627449 endingPage "2098" @default.
• W2914627449 startingPage "2087" @default.
• W2914627449 abstract "Cutinases are enzymes known to degrade polyester-type plastics. Est119, a plastic-degrading type of cutinase from Thermobifida alba AHK119 (herein called Ta_cut), shows a broad substrate specificity toward polyesters, and can degrade substrates including polylactic acid (PLA). However, the PLA-degrading mechanism of cutinases is still poorly understood. Here, we report the structure complexes of cutinase with ethyl lactate (EL), the constitutional unit. From this complex structure, the electron density maps clearly showed one lactate (LAC) and one EL occupying different positions in the active site cleft. The binding mode of EL is assumed to show a figure prior to reaction and LAC is an after-reaction product. These complex structures demonstrate the role of active site residues in the esterase reaction and substrate recognition. The complex structures were compared with other documented complex structures of cutinases and with the structure of PETase from Ideonella sakaiensis. The amino acid residues involved in substrate interaction are highly conserved among these enzymes. Thus, mapping the precise interactions in the Ta_cut and EL complex will pave the way for understanding the plastic-degrading mechanism of cutinases and suggest ways of creating more potent enzymes by structural protein engineering." @default.
• W2914627449 created "2019-02-21" @default.
• W2914627449 creator A5013150065 @default.
• W2914627449 creator A5039612886 @default.
• W2914627449 creator A5049299096 @default.
• W2914627449 creator A5062219449 @default.
• W2914627449 creator A5070718382 @default.
• W2914627449 creator A5073138684 @default.
• W2914627449 creator A5081898662 @default.
• W2914627449 date "2019-02-28" @default.
• W2914627449 modified "2023-10-14" @default.
• W2914627449 title "Structural insights into the unique polylactate‐degrading mechanism of <i>Thermobifida alba</i> cutinase" @default.
• W2914627449 cites W1976183189 @default.
• W2914627449 cites W1983120001 @default.
• W2914627449 cites W2001930581 @default.
• W2914627449 cites W2019235724 @default.
• W2914627449 cites W2030517878 @default.
• W2914627449 cites W2031349028 @default.
• W2914627449 cites W2042706604 @default.
• W2914627449 cites W2060807817 @default.
• W2914627449 cites W2074473216 @default.
• W2914627449 cites W2093133068 @default.
• W2914627449 cites W2159211495 @default.
• W2914627449 cites W2163341755 @default.
• W2914627449 cites W2166537396 @default.
• W2914627449 cites W2294707565 @default.
• W2914627449 cites W2339329901 @default.
• W2914627449 cites W2594021531 @default.
• W2914627449 cites W2599977611 @default.
• W2914627449 cites W2734153960 @default.
• W2914627449 cites W2737217596 @default.
• W2914627449 cites W2774452071 @default.
• W2914627449 cites W2786189709 @default.
• W2914627449 cites W2794908918 @default.
• W2914627449 cites W2795284646 @default.
• W2914627449 cites W2801256450 @default.
• W2914627449 cites W2886639208 @default.
• W2914627449 cites W2892949128 @default.
• W2914627449 cites W4248872320 @default.
• W2914627449 doi "https://doi.org/10.1111/febs.14781" @default.
• W2914627449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30761732" @default.
• W2914627449 hasPublicationYear "2019" @default.
• W2914627449 type Work @default.
• W2914627449 sameAs 2914627449 @default.
• W2914627449 citedByCount "37" @default.
• W2914627449 countsByYear W29146274492019 @default.
• W2914627449 countsByYear W29146274492020 @default.
• W2914627449 countsByYear W29146274492021 @default.
• W2914627449 countsByYear W29146274492022 @default.
• W2914627449 countsByYear W29146274492023 @default.
• W2914627449 crossrefType "journal-article" @default.
• W2914627449 hasAuthorship W2914627449A5013150065 @default.
• W2914627449 hasAuthorship W2914627449A5039612886 @default.
• W2914627449 hasAuthorship W2914627449A5049299096 @default.
• W2914627449 hasAuthorship W2914627449A5062219449 @default.
• W2914627449 hasAuthorship W2914627449A5070718382 @default.
• W2914627449 hasAuthorship W2914627449A5073138684 @default.
• W2914627449 hasAuthorship W2914627449A5081898662 @default.
• W2914627449 hasBestOaLocation W29146274491 @default.
• W2914627449 hasConcept C119394753 @default.
• W2914627449 hasConcept C178790620 @default.
• W2914627449 hasConcept C181199279 @default.
• W2914627449 hasConcept C185592680 @default.
• W2914627449 hasConcept C18903297 @default.
• W2914627449 hasConcept C2777261171 @default.
• W2914627449 hasConcept C2777289219 @default.
• W2914627449 hasConcept C2777613533 @default.
• W2914627449 hasConcept C41183919 @default.
• W2914627449 hasConcept C47701112 @default.
• W2914627449 hasConcept C55493867 @default.
• W2914627449 hasConcept C71240020 @default.
• W2914627449 hasConcept C86803240 @default.
• W2914627449 hasConceptScore W2914627449C119394753 @default.
• W2914627449 hasConceptScore W2914627449C178790620 @default.
• W2914627449 hasConceptScore W2914627449C181199279 @default.
• W2914627449 hasConceptScore W2914627449C185592680 @default.
• W2914627449 hasConceptScore W2914627449C18903297 @default.
• W2914627449 hasConceptScore W2914627449C2777261171 @default.
• W2914627449 hasConceptScore W2914627449C2777289219 @default.
• W2914627449 hasConceptScore W2914627449C2777613533 @default.
• W2914627449 hasConceptScore W2914627449C41183919 @default.
• W2914627449 hasConceptScore W2914627449C47701112 @default.
• W2914627449 hasConceptScore W2914627449C55493867 @default.
• W2914627449 hasConceptScore W2914627449C71240020 @default.
• W2914627449 hasConceptScore W2914627449C86803240 @default.
• W2914627449 hasIssue "11" @default.
• W2914627449 hasLocation W29146274491 @default.
• W2914627449 hasLocation W29146274492 @default.
• W2914627449 hasOpenAccess W2914627449 @default.
• W2914627449 hasPrimaryLocation W29146274491 @default.
• W2914627449 hasRelatedWork W1592972783 @default.
• W2914627449 hasRelatedWork W2006061177 @default.
• W2914627449 hasRelatedWork W2052458251 @default.
• W2914627449 hasRelatedWork W2063315327 @default.
• W2914627449 hasRelatedWork W2094123806 @default.
• W2914627449 hasRelatedWork W2129656688 @default.
• W2914627449 hasRelatedWork W2326011188 @default.
• W2914627449 hasRelatedWork W2580775658 @default.

• next