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• W2914628204 abstract "Event Abstract Back to Event Language Decline in Primary Progressive Aphasia: Patterns and Prognostic Variables Rajani Sebastian1, Amy Wright1, Aaron Meyer2, Rhonda Friedman2, Argye E. Hillis1, 3, 4 and Donna C. Tippett1, 3, 5* 1 Johns Hopkins Medicine, Department of Neurology, United States 2 Georgetown University Medical Center, United States 3 Johns Hopkins University, Department of Physical Medicine and Rehabilitation, United States 4 Johns Hopkins University, Department of Cognitive Science, United States 5 Johns Hopkins Medicine, Department of Otolaryngology--Head and Neck Surgery, United States Problem The aim of this study was to investigate patterns of decline on language testing in each of the clinical subtypes of PPA (logopenic variant PPA, lvPPA; nonfluent agrammatic PPA, nfaPPA; and semantic variant PPA, svPPA) and to examine the effects of other variables on rate of decline. We hypothesized that speech-language rehabilitation, higher education, and higher baseline test scores would be associated with slower decline, and older age with faster decline. Method Thirty-six patients with lvPPA (mean age = 69.3 years; SD = 8.01; mean education = 16.6 years; SD = 2.90), 31 patients with nfaPPA (mean age = 67.7 years; SD = 9.61; mean education = 15.8 years; SD = 2.58), and 27 patients with svPPA (mean age = 64.1 years; SD = 7.39; mean education = 15.8 years; SD = 2.01) were included. Participants (n = 94; mean age = 67.3 years; SD = 8.59; 58 female; mean education = 16.1 years; SD = 2.57) completed language testing on at least two occasions. Follow up testing ranged from 11 to 44 months post baseline (mean interval 19.1 months; SD = 6.62). We focused on decline on three tests: Boston Naming Test, short form (BNT; Kaplan, Goodglass, & Weintraub, 2001; Mack, Freed, Williams, & Henderson, 1992); Hopkins Assessment of Naming Actions (HANA; Lala, Race, Tsapkini, & Hillis, 2012), and the picture short form of the Pyramids and Palm Trees Test (PPTT) (Breining et al., 2015). A multivariate regression model was used to study language decline over time. Results PPA subtypes were distinguishable by rapidity of decline. Across language tests, the most precipitous rates of decline (loss of points per month) occurred in nfaPPA (BNT: 0.91 points per month, p<0.0001; HANA: 0.76 points per month, p <0.0001; PPTT: 0.35 points per month, p <0.0001), followed by svPPA (BNT: 0.35 points per month, p <0.0001; HANA: 0.23 points per month, p <0.0001; PPTT: 0.05 points per month, p =0.001), and then lvPPA (BNT: 0.24, points per month, p=0.002; HANA: 0.10 points per month, p = 0.060; PPTT: 0.02 points per month, p = 0.138). All scores had a 95% confidence interval. This steep downward trajectory for nfaPPA may be explained, in part, because, individuals present with apraxia of speech and may become mute early in their disease progression (Croot, Ballard, Leyton, & Hodges, 2012; Gorno-Tempini et al., 2006), thereby compromising performance on confrontation naming. Female gender, longer symptom duration, higher baseline test score, and speech-language rehabilitation were associated with slower decline. Conclusions PPA variants were distinguishable by rapidity of decline, with nfaPPA having the most precipitous decline. As hypothesized, higher baseline test scores and speech-language rehabilitation were associated with slower decline. Surprisingly, age and education were not important prognostically for individuals in this study. These variables, however, influence recovery from stroke (Hillis & Tippett, 2014). Further study of prognostically relevant variables in PPA is indicated in this population. The ability to predict decline in function, and advise individuals with PPA and their caregivers regarding future planning, would be invaluable clinically. Acknowledgements This work was made possible by NIH grants ROI DC 011317, R01 DC 03681, and K99 DC015554 from NIDCD. We gratefully acknowledge this support. References Breining, B. L., Lala, T., Martínez Cuitiño, M., Manes, F., Peristeri, E., Tsapkini, K., . . . Hillis, A. E. (2015). A brief assessment of object semantics in primary progressive aphasia. Aphasiology, 29(4), 488-505. Croot, K., Ballard, K., Leyton, C.E., & Hodges, J.R. (2012). Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia. Journal of Speech, Language, and Hearing Research, 55, S1562-72. doi: 10.1044/1092-4388(2012/11-0323. Gorno-Tempini, M.L., Ogar, J.M., Brambati, S.M., Wang, P., Jeong, J.H., Rankin, K.P., . . . & Miller, B.L. (2006). Anatomical correlates of early mutism in progressive nonfluent aphasia. Neurology, 67, 1849-1851. doi: 10.1212/01.wnl.0000237038.55627.5b. Hillis, A. E., & Tippett, D. C. (2014). Stroke recovery: Surprising influences and residual consequences. Advances in Medicine, 2014 Kaplan, E., Goodglass, H., & Weintraub, S. (2001). Boston naming test-2 (BNT- 2). Austin TX: Pro-Ed. Mack, W.J., Freed, D.M., Williams, B.W., & Henderson, V.W. (1992). Boston naming test: Shortened versions for use in Alzheimer’s disease. Journal of Gerontology, 47, 154-158. doi: 10.1093/geronj/47.3.P154. Keywords: primary progressive aphasia, Language decline, semantic variant primary progressive aphasia, nonfluent agrammatic primary progressive aphasia, logopenic variant primary progressive aphasia Conference: Academy of Aphasia 55th Annual Meeting , Baltimore, United States, 5 Nov - 7 Nov, 2017. Presentation Type: poster or oral Topic: Consider for student award Citation: Sebastian R, Wright A, Meyer A, Friedman R, Hillis AE and Tippett DC (2019). Language Decline in Primary Progressive Aphasia: Patterns and Prognostic Variables. Conference Abstract: Academy of Aphasia 55th Annual Meeting . doi: 10.3389/conf.fnhum.2017.223.00074 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 20 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Ms. Donna C Tippett, Johns Hopkins Medicine, Department of Neurology, Baltimore, Maryland, 21287, United States, dtippet1@jhmi.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Rajani Sebastian Amy Wright Aaron Meyer Rhonda Friedman Argye E Hillis Donna C Tippett Google Rajani Sebastian Amy Wright Aaron Meyer Rhonda Friedman Argye E Hillis Donna C Tippett Google Scholar Rajani Sebastian Amy Wright Aaron Meyer Rhonda Friedman Argye E Hillis Donna C Tippett PubMed Rajani Sebastian Amy Wright Aaron Meyer Rhonda Friedman Argye E Hillis Donna C Tippett Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2914628204 title "Language Decline in Primary Progressive Aphasia: Patterns and Prognostic Variables" @default.
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