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- W2914649596 abstract "Dupilumab, a monoclonal antibody against IL-4 receptor alpha (IL-4Rα) that blocks signaling of IL-4 and IL-13 cytokines, is approved by FDA for treatment of severe atopic dermatitis. TH2 cytokines such as IL-4 and IL-13 are involved in the pathogenesis of atopic dermatitis and other allergic disorders. More recently, group 2 innate lymphoid cells (ILC2s) have been described to play a role in allergic disorders including atopic dermatitis. ILC2s produce TH2 cytokines including IL-4 and IL-13. We sought to identify the effect of dupilumab, which blocks IL-4 and IL-13 signaling, on ILC2s. Five patients with severe atopic dermatitis treated with dupilumab and three healthy controls were recruited from Albany Medical College Allergy Clinic. Peripheral blood mononuclear cells were separated from whole blood using Ficoll method. Flow cytometry was used to identify ILC2s. In a subset of patients with severe atopic dermatitis on dupilumab, results showed there was reduced frequency of ILC2 compared to healthy controls. Inhibition of IL-4 and IL-13 signaling through IL-4Rα may lead to decrease frequency of ILC2. More studies are needed to understand the exact mechanism by which IL-4 receptor signaling pathway affects ILC2s." @default.
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- W2914649596 date "2019-02-01" @default.
- W2914649596 modified "2023-09-27" @default.
- W2914649596 title "Group 2 Innate Lymphoid Cells in Patients with Severe Atopic Dermatitis on Dupilumab" @default.
- W2914649596 doi "https://doi.org/10.1016/j.jaci.2018.12.059" @default.
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