Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914653619> ?p ?o ?g. }
- W2914653619 abstract "The mitochondrial carrier family is a group of transport proteins that are mostly localized to the inner mitochondrial membrane where they facilitate the movement of various solutes across the membrane. Although these carriers represent potential targets for therapeutic application and are repeatedly associated with human disease, research on the mitochondrial carrier family has not progressed commensurate to their physiologic and pathophysiologic importance. Many of the 53 mitochondrial carrier family members in humans are orphans and lack known transport substrates. Even for the relatively well-studied members of this family, such as the ADP/ATP carrier and the uncoupling protein, there exist fundamental gaps in our understanding of their biological roles including a clear rationale for the existence of multiple isoforms. Here, we briefly review this important family of mitochondrial carriers, provide a few salient examples of their diverse metabolic roles and disease associations, and then focus on an emerging link between several distinct mitochondrial carrier family members, including the ADP/ATP carrier, and cytochrome c oxidase biogenesis. As the ADP/ATP carrier is regarded as the paradigm of the entire mitochondrial carrier family, its newly established role in regulating translation of the mitochondrial genome highlights that we still have a lot to learn about these metabolite transporters." @default.
- W2914653619 created "2019-02-21" @default.
- W2914653619 creator A5011046739 @default.
- W2914653619 creator A5051305516 @default.
- W2914653619 date "2019-01-31" @default.
- W2914653619 modified "2023-10-18" @default.
- W2914653619 title "Emerging Roles in the Biogenesis of Cytochrome c Oxidase for Members of the Mitochondrial Carrier Family" @default.
- W2914653619 cites W111217621 @default.
- W2914653619 cites W129717176 @default.
- W2914653619 cites W1482057189 @default.
- W2914653619 cites W1498584081 @default.
- W2914653619 cites W1508295900 @default.
- W2914653619 cites W1511403368 @default.
- W2914653619 cites W1528972162 @default.
- W2914653619 cites W1537499542 @default.
- W2914653619 cites W15420744 @default.
- W2914653619 cites W1567965797 @default.
- W2914653619 cites W1573108780 @default.
- W2914653619 cites W1582208830 @default.
- W2914653619 cites W1594539479 @default.
- W2914653619 cites W1594967972 @default.
- W2914653619 cites W1608709490 @default.
- W2914653619 cites W1820155366 @default.
- W2914653619 cites W1849928642 @default.
- W2914653619 cites W1880032027 @default.
- W2914653619 cites W188590037 @default.
- W2914653619 cites W1894313788 @default.
- W2914653619 cites W1920447776 @default.
- W2914653619 cites W1924557697 @default.
- W2914653619 cites W1929991616 @default.
- W2914653619 cites W1964690839 @default.
- W2914653619 cites W1965210942 @default.
- W2914653619 cites W1965285497 @default.
- W2914653619 cites W1965399930 @default.
- W2914653619 cites W1966377847 @default.
- W2914653619 cites W1967057928 @default.
- W2914653619 cites W1967961684 @default.
- W2914653619 cites W1968217511 @default.
- W2914653619 cites W1970794681 @default.
- W2914653619 cites W1971281323 @default.
- W2914653619 cites W1972482762 @default.
- W2914653619 cites W1972666591 @default.
- W2914653619 cites W1972998779 @default.
- W2914653619 cites W1976748679 @default.
- W2914653619 cites W1977142594 @default.
- W2914653619 cites W1977409262 @default.
- W2914653619 cites W1978294917 @default.
- W2914653619 cites W1978327824 @default.
- W2914653619 cites W1978728375 @default.
- W2914653619 cites W1980656964 @default.
- W2914653619 cites W1980722024 @default.
- W2914653619 cites W1981254976 @default.
- W2914653619 cites W1981770722 @default.
- W2914653619 cites W1982753455 @default.
- W2914653619 cites W1983126914 @default.
- W2914653619 cites W1983297378 @default.
- W2914653619 cites W1983666695 @default.
- W2914653619 cites W1983729336 @default.
- W2914653619 cites W1983930192 @default.
- W2914653619 cites W1984561144 @default.
- W2914653619 cites W1984713905 @default.
- W2914653619 cites W1984981644 @default.
- W2914653619 cites W1985657228 @default.
- W2914653619 cites W1986248905 @default.
- W2914653619 cites W1986963451 @default.
- W2914653619 cites W1988627015 @default.
- W2914653619 cites W1989864100 @default.
- W2914653619 cites W1991273032 @default.
- W2914653619 cites W1993957397 @default.
- W2914653619 cites W1994191301 @default.
- W2914653619 cites W1995873637 @default.
- W2914653619 cites W1998475753 @default.
- W2914653619 cites W1999021477 @default.
- W2914653619 cites W2000844947 @default.
- W2914653619 cites W2002139629 @default.
- W2914653619 cites W2004801196 @default.
- W2914653619 cites W2005911187 @default.
- W2914653619 cites W2006849545 @default.
- W2914653619 cites W2009636878 @default.
- W2914653619 cites W2010594727 @default.
- W2914653619 cites W2011269462 @default.
- W2914653619 cites W2012392242 @default.
- W2914653619 cites W2012622920 @default.
- W2914653619 cites W2016620855 @default.
- W2914653619 cites W2017160931 @default.
- W2914653619 cites W2017213538 @default.
- W2914653619 cites W2018860722 @default.
- W2914653619 cites W2019956248 @default.
- W2914653619 cites W2022075894 @default.
- W2914653619 cites W2022562250 @default.
- W2914653619 cites W2023530279 @default.
- W2914653619 cites W2024334744 @default.
- W2914653619 cites W2027439869 @default.
- W2914653619 cites W2028133321 @default.
- W2914653619 cites W2028473545 @default.
- W2914653619 cites W2029144840 @default.
- W2914653619 cites W2029222949 @default.
- W2914653619 cites W2030073764 @default.
- W2914653619 cites W2030324194 @default.
- W2914653619 cites W2030548279 @default.