FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914654038> ?p ?o ?g. }

• W2914654038 endingPage "2756" @default.
• W2914654038 startingPage "2748" @default.
• W2914654038 abstract "Abstract Context Calcium and vitamin D treatment does not improve reduced quality of life (QOL) in hypoparathyroidism. Recombinant human (rh) PTH(1-84) therapy improves QOL metrics for up to 5 years. Data on QOL beyond this time point are not available. Objectives To evaluate the effects of 8 years of rhPTH(1-84) therapy on QOL and factors associated with long-term benefit. Design Prospective, open-label trial. Setting Referral center. Patients Twenty patients with hypoparathyoidism. Main Outcome Measures RAND 36-Item Short Form Health Survey (SF-36). Results rhPTH therapy led to substantial improvement in five of the eight SF-36 domains [vitality, social functioning (SF), mental health (MH), bodily pain (BP) and general health] and three of these domains (SF, MH, BP) were no longer lower than the reference population. The improvement in the mental component summary (MCS) score was sustained through 8 years, while the physical component summary (PCS) score improved through 6 years. A lower baseline QOL score was associated with greater improvement. A threshold value &lt;238 (MCS) and &lt;245 (PCS) predicted long-term improvement in 90% and 100% of the cohort, respectively. In patients whose calcium supplementation was reduced, MCS and PCS scores improved more than those whose supplementation did not decline to the same extent. Improvement in PCS was greater in patients whose calcitriol dosage was reduced and duration of disease was shorter. Conclusions rhPTH(1-84) improves long-term well-being in hypoparathyroidism. The improvements are most prominent in those with impaired SF-36 at baseline and those whose requirements for conventional therapy decreased substantially." @default.
• W2914654038 created "2019-02-21" @default.
• W2914654038 creator A5013126573 @default.
• W2914654038 creator A5020641400 @default.
• W2914654038 creator A5030690224 @default.
• W2914654038 creator A5042148258 @default.
• W2914654038 creator A5049840252 @default.
• W2914654038 creator A5057071617 @default.
• W2914654038 creator A5071022650 @default.
• W2914654038 creator A5083350007 @default.
• W2914654038 creator A5089834841 @default.
• W2914654038 date "2019-02-18" @default.
• W2914654038 modified "2023-10-12" @default.
• W2914654038 title "Quality of Life in Hypoparathyroidism Improves With rhPTH(1-84) Throughout 8 Years of Therapy" @default.
• W2914654038 cites W1964982552 @default.
• W2914654038 cites W1966916031 @default.
• W2914654038 cites W1969080702 @default.
• W2914654038 cites W1993280347 @default.
• W2914654038 cites W1998141704 @default.
• W2914654038 cites W2000198393 @default.
• W2914654038 cites W2035531544 @default.
• W2914654038 cites W2037377025 @default.
• W2914654038 cites W2044995747 @default.
• W2914654038 cites W2051155551 @default.
• W2914654038 cites W2072220728 @default.
• W2914654038 cites W2083586358 @default.
• W2914654038 cites W2087723635 @default.
• W2914654038 cites W2091222735 @default.
• W2914654038 cites W2101979152 @default.
• W2914654038 cites W2110422519 @default.
• W2914654038 cites W2130815518 @default.
• W2914654038 cites W2131821568 @default.
• W2914654038 cites W2159492920 @default.
• W2914654038 cites W2167388509 @default.
• W2914654038 cites W2179017712 @default.
• W2914654038 cites W2289379672 @default.
• W2914654038 cites W2405079443 @default.
• W2914654038 cites W2530780656 @default.
• W2914654038 cites W2745586615 @default.
• W2914654038 cites W2753569127 @default.
• W2914654038 cites W2766126031 @default.
• W2914654038 cites W4231900100 @default.
• W2914654038 cites W4245776924 @default.
• W2914654038 cites W4292806894 @default.
• W2914654038 cites W68836595 @default.
• W2914654038 doi "https://doi.org/10.1210/jc.2018-02430" @default.
• W2914654038 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6530656" @default.
• W2914654038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30776291" @default.
• W2914654038 hasPublicationYear "2019" @default.
• W2914654038 type Work @default.
• W2914654038 sameAs 2914654038 @default.
• W2914654038 citedByCount "42" @default.
• W2914654038 countsByYear W29146540382019 @default.
• W2914654038 countsByYear W29146540382020 @default.
• W2914654038 countsByYear W29146540382021 @default.
• W2914654038 countsByYear W29146540382022 @default.
• W2914654038 countsByYear W29146540382023 @default.
• W2914654038 crossrefType "journal-article" @default.
• W2914654038 hasAuthorship W2914654038A5013126573 @default.
• W2914654038 hasAuthorship W2914654038A5020641400 @default.
• W2914654038 hasAuthorship W2914654038A5030690224 @default.
• W2914654038 hasAuthorship W2914654038A5042148258 @default.
• W2914654038 hasAuthorship W2914654038A5049840252 @default.
• W2914654038 hasAuthorship W2914654038A5057071617 @default.
• W2914654038 hasAuthorship W2914654038A5071022650 @default.
• W2914654038 hasAuthorship W2914654038A5083350007 @default.
• W2914654038 hasAuthorship W2914654038A5089834841 @default.
• W2914654038 hasBestOaLocation W29146540381 @default.
• W2914654038 hasConcept C121608353 @default.
• W2914654038 hasConcept C124490489 @default.
• W2914654038 hasConcept C126322002 @default.
• W2914654038 hasConcept C134018914 @default.
• W2914654038 hasConcept C151730666 @default.
• W2914654038 hasConcept C159110408 @default.
• W2914654038 hasConcept C1862650 @default.
• W2914654038 hasConcept C2775941721 @default.
• W2914654038 hasConcept C2776079296 @default.
• W2914654038 hasConcept C2776237627 @default.
• W2914654038 hasConcept C2779134260 @default.
• W2914654038 hasConcept C2779343474 @default.
• W2914654038 hasConcept C2779951463 @default.
• W2914654038 hasConcept C2780275930 @default.
• W2914654038 hasConcept C2908647359 @default.
• W2914654038 hasConcept C3019006561 @default.
• W2914654038 hasConcept C530470458 @default.
• W2914654038 hasConcept C71924100 @default.
• W2914654038 hasConcept C86803240 @default.
• W2914654038 hasConcept C99454951 @default.
• W2914654038 hasConceptScore W2914654038C121608353 @default.
• W2914654038 hasConceptScore W2914654038C124490489 @default.
• W2914654038 hasConceptScore W2914654038C126322002 @default.
• W2914654038 hasConceptScore W2914654038C134018914 @default.
• W2914654038 hasConceptScore W2914654038C151730666 @default.
• W2914654038 hasConceptScore W2914654038C159110408 @default.
• W2914654038 hasConceptScore W2914654038C1862650 @default.
• W2914654038 hasConceptScore W2914654038C2775941721 @default.
• W2914654038 hasConceptScore W2914654038C2776079296 @default.
• W2914654038 hasConceptScore W2914654038C2776237627 @default.

• next