FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914676841> ?p ?o ?g. }

• W2914676841 endingPage "704" @default.
• W2914676841 startingPage "703" @default.
• W2914676841 abstract "Since prehistoric times, humans have used natural products, such as plants, animals, microorganisms, and marine organisms in medicines to alleviate and treat illness. These remedies are often prescribed as part of traditional medicine, a discipline that has been built over the ages based on empirical knowledge that was passed down through the generations. Herbal remedies are aimed at wellness and general disease states, whereas conventional pharmaceuticals are directed at specific molecular disease targets.Herbal remedies come from various sources where growth, harvesting, and storage conditions can alter the amount of the active ingredients substantially. In addition, fungal and other organic and inorganic contaminants add to the complexity of safety assessment. Sometimes adulterants are intentionally added for the purpose of efficacy.Herbal remedies are labeled as mg of the plant, an extract (in mg or percent), or the active ingredient in mg, e.g., capsules containing 80 mg of the herb [Ginger root 750 mg], or capsules containing 80 mg of the active [Saint John's Wort 300 mg–0.3% hypericin], or as a straight concentration [CBD oil 2.5%] for the purpose of dosage. The therapeutic index for herbal remedies is large: the recommended doses for herbs are usually in milligrams per 70 kg person compared to toxicity experiments that require grams per kilogram for an effect. This does not mean that herbal remedies are innocuous, as most users are aware of the intrinsic hazard of some herbal remedies and risk of exposure, cigarette smoking, for example.In toxicologic pathology, the organ of impact following herbal remedy overdose, like conventional pharmaceuticals, is usually the liver. However, toxicity can be seen in other organs such as the heart, following Digitalis exposure. Goldenseal root power [Hydrastis canadensis]), Gingko biloba extract [Ginkgo biloba], Riddelliine (pyrrolizidine alkaloid), Pulegone [Mentha sp.], Kava kava [Piper methysticum], and Indole-3-carbinol [Brassica sp.] are hepatotoxic at the doses given experimentally. In addition, some herbs have been classified as carcinogens based on experimental evidence. The International Agency for Research on Cancer (IARC) has reviewed the evidence for carcinogenic activity for four of these herbal remedies (Goldenseal, Gingko, Kava, and Pulegone), and classified them as “possibly carcinogenic to humans” (Group 2B) because of evidence for carcinogenic activity in two species or both sexes of the same rodent species.Other target organs damaged during high exposure include the gastrointestinal tract: Aloe vera and Senna; kidney: Aloe vera, raw Garlic, Ginkgo, Kava kava, Pulegone, St John's wort, and Tobacco; heart: Ephedra; and the vascular system: Riddelliine pyrrolizidine alkaloid and Tobacco.Milk thistle, Turmeric oleoresin, Green tea extract studies did not provide clear evidence for carcinogenic activity in rodent model systems nor did Marijuana, Chamomile, Coffee, Cocoa, Echinacea, Ephedra, Ginger, Ginseng, St. John's wort, and Turmeric.The scope of this chapter is limited to herbal remedies. Other supplements will not be part of the discussion except to illustrate specific points regarding herbal remedies. In this chapter we explore the use of herbal remedies in medical treatment regimens, differentiate traditional from scientific knowledge and discovery, the issue of quality in herbal remedies, and the difficulties in obtaining precise dose–response data for safety and efficacy." @default.
• W2914676841 created "2019-02-21" @default.
• W2914676841 creator A5054767678 @default.
• W2914676841 date "1974-10-01" @default.
• W2914676841 modified "2023-10-09" @default.
• W2914676841 title "Monographs of fragrance raw materials" @default.
• W2914676841 cites W2912729716 @default.
• W2914676841 doi "https://doi.org/10.1016/0015-6264(74)90242-9" @default.
• W2914676841 hasPublicationYear "1974" @default.
• W2914676841 type Work @default.
• W2914676841 sameAs 2914676841 @default.
• W2914676841 citedByCount "18" @default.
• W2914676841 countsByYear W29146768412012 @default.
• W2914676841 countsByYear W29146768412023 @default.
• W2914676841 crossrefType "journal-article" @default.
• W2914676841 hasAuthorship W2914676841A5054767678 @default.
• W2914676841 hasConcept C2779824472 @default.
• W2914676841 hasConcept C2987920364 @default.
• W2914676841 hasConcept C2991655182 @default.
• W2914676841 hasConcept C33070731 @default.
• W2914676841 hasConcept C45904493 @default.
• W2914676841 hasConcept C556039675 @default.
• W2914676841 hasConcept C71924100 @default.
• W2914676841 hasConcept C86803240 @default.
• W2914676841 hasConcept C98274493 @default.
• W2914676841 hasConcept C99454951 @default.
• W2914676841 hasConceptScore W2914676841C2779824472 @default.
• W2914676841 hasConceptScore W2914676841C2987920364 @default.
• W2914676841 hasConceptScore W2914676841C2991655182 @default.
• W2914676841 hasConceptScore W2914676841C33070731 @default.
• W2914676841 hasConceptScore W2914676841C45904493 @default.
• W2914676841 hasConceptScore W2914676841C556039675 @default.
• W2914676841 hasConceptScore W2914676841C71924100 @default.
• W2914676841 hasConceptScore W2914676841C86803240 @default.
• W2914676841 hasConceptScore W2914676841C98274493 @default.
• W2914676841 hasConceptScore W2914676841C99454951 @default.
• W2914676841 hasIssue "5-6" @default.
• W2914676841 hasLocation W29146768411 @default.
• W2914676841 hasOpenAccess W2914676841 @default.
• W2914676841 hasPrimaryLocation W29146768411 @default.
• W2914676841 hasRelatedWork W1915073081 @default.
• W2914676841 hasRelatedWork W2352544315 @default.
• W2914676841 hasRelatedWork W2357369346 @default.
• W2914676841 hasRelatedWork W2385590096 @default.
• W2914676841 hasRelatedWork W2393979392 @default.
• W2914676841 hasRelatedWork W2418728716 @default.
• W2914676841 hasRelatedWork W3185653215 @default.
• W2914676841 hasRelatedWork W3214134352 @default.
• W2914676841 hasRelatedWork W342615289 @default.
• W2914676841 hasRelatedWork W4322504657 @default.
• W2914676841 hasVolume "12" @default.
• W2914676841 isParatext "false" @default.
• W2914676841 isRetracted "false" @default.
• W2914676841 magId "2914676841" @default.
• W2914676841 workType "article" @default.