Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914677939> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2914677939 abstract "Differential expression pathways and hub genes in circulating monocytes from healthy Chinese women with high peak bone mass (PBM) vs. low PBM were explored using a Markov chain Monte Carlo (MCMC) algorithm. Human circulating monocytes transcription profiling (containing 14 samples with high PBM and 12 samples with low PBM) and KEGG pathways were all downloaded from the public database. Initial state of all the pathways were constructed and Gibbs sampling was performed to obtain a Markov chain and the posterior values of all the pathways were calculated. The probability (α) of occurrence of each pathway was calculated based on the posterior value and it was adjusted by taking gene expression variation into account. Pathways with αadj >0.8 were considered as differentially expressed pathways. Then, these steps were performed again on all the genes in the differentially expressed pathways to find the hub genes in the differential pathways. After Gibbs sampling, neuroactive ligand-receptor interaction (hsa04080) with αadj = 0.986 was screened out as the differentially expressed pathway. Analyzing the genes in this pathway, three genes (neurotensin, tachykinin receptor 3 and follicle-stimulating hormone receptor) with αadj >0.8 were identified as hub genes in circulating monocytes which may associate with osteoporosis development. One pathway and three genes which may possess close relationship with osteoporosis development were found in this study. These results provide insights into our understanding of the role of circulating monocytes in osteoporosis development." @default.
- W2914677939 created "2019-02-21" @default.
- W2914677939 creator A5033050035 @default.
- W2914677939 creator A5071509951 @default.
- W2914677939 date "2019-01-31" @default.
- W2914677939 modified "2023-10-01" @default.
- W2914677939 title "Screening pathways and hub genes involved in osteoclastogenesis by gene expression analysis of circulating monocytes based on Gibbs sampling" @default.
- W2914677939 cites W1676884362 @default.
- W2914677939 cites W1838573250 @default.
- W2914677939 cites W1917843524 @default.
- W2914677939 cites W1964815707 @default.
- W2914677939 cites W1977443233 @default.
- W2914677939 cites W2015994373 @default.
- W2914677939 cites W2033053828 @default.
- W2914677939 cites W2037723081 @default.
- W2914677939 cites W2064543792 @default.
- W2914677939 cites W2095081699 @default.
- W2914677939 cites W2109972881 @default.
- W2914677939 cites W2116722937 @default.
- W2914677939 cites W2120865735 @default.
- W2914677939 cites W2159482845 @default.
- W2914677939 cites W2170520557 @default.
- W2914677939 cites W2317897431 @default.
- W2914677939 cites W2332963608 @default.
- W2914677939 cites W2346895693 @default.
- W2914677939 cites W2522692264 @default.
- W2914677939 cites W2562079402 @default.
- W2914677939 cites W2594750015 @default.
- W2914677939 cites W2762784553 @default.
- W2914677939 cites W4294216483 @default.
- W2914677939 cites W929068048 @default.
- W2914677939 doi "https://doi.org/10.3892/etm.2019.7225" @default.
- W2914677939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6425127" @default.
- W2914677939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30906441" @default.
- W2914677939 hasPublicationYear "2019" @default.
- W2914677939 type Work @default.
- W2914677939 sameAs 2914677939 @default.
- W2914677939 citedByCount "5" @default.
- W2914677939 countsByYear W29146779392020 @default.
- W2914677939 countsByYear W29146779392021 @default.
- W2914677939 countsByYear W29146779392022 @default.
- W2914677939 countsByYear W29146779392023 @default.
- W2914677939 crossrefType "journal-article" @default.
- W2914677939 hasAuthorship W2914677939A5033050035 @default.
- W2914677939 hasAuthorship W2914677939A5071509951 @default.
- W2914677939 hasBestOaLocation W29146779391 @default.
- W2914677939 hasConcept C104317684 @default.
- W2914677939 hasConcept C150194340 @default.
- W2914677939 hasConcept C152724338 @default.
- W2914677939 hasConcept C162317418 @default.
- W2914677939 hasConcept C18431079 @default.
- W2914677939 hasConcept C54355233 @default.
- W2914677939 hasConcept C62478195 @default.
- W2914677939 hasConcept C86803240 @default.
- W2914677939 hasConcept C9927688 @default.
- W2914677939 hasConceptScore W2914677939C104317684 @default.
- W2914677939 hasConceptScore W2914677939C150194340 @default.
- W2914677939 hasConceptScore W2914677939C152724338 @default.
- W2914677939 hasConceptScore W2914677939C162317418 @default.
- W2914677939 hasConceptScore W2914677939C18431079 @default.
- W2914677939 hasConceptScore W2914677939C54355233 @default.
- W2914677939 hasConceptScore W2914677939C62478195 @default.
- W2914677939 hasConceptScore W2914677939C86803240 @default.
- W2914677939 hasConceptScore W2914677939C9927688 @default.
- W2914677939 hasLocation W29146779391 @default.
- W2914677939 hasLocation W29146779392 @default.
- W2914677939 hasLocation W29146779393 @default.
- W2914677939 hasLocation W29146779394 @default.
- W2914677939 hasOpenAccess W2914677939 @default.
- W2914677939 hasPrimaryLocation W29146779391 @default.
- W2914677939 hasRelatedWork W1556453709 @default.
- W2914677939 hasRelatedWork W2187437179 @default.
- W2914677939 hasRelatedWork W2371696992 @default.
- W2914677939 hasRelatedWork W2377598758 @default.
- W2914677939 hasRelatedWork W2563598809 @default.
- W2914677939 hasRelatedWork W2580080859 @default.
- W2914677939 hasRelatedWork W2782502720 @default.
- W2914677939 hasRelatedWork W2962330546 @default.
- W2914677939 hasRelatedWork W4294954873 @default.
- W2914677939 hasRelatedWork W4316464720 @default.
- W2914677939 isParatext "false" @default.
- W2914677939 isRetracted "false" @default.
- W2914677939 magId "2914677939" @default.
- W2914677939 workType "article" @default.