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• W2914686075 startingPage "237" @default.
• W2914686075 abstract "Attention-deficit hyperactivity disorder (ADHD) is a disorder of inattention, impulsivity, and hyperactivity that affects 8-12% of children worldwide. Although the rate of ADHD falls with age, at least half of children with the disorder will have impairing symptoms in adulthood. Twin, adoption, and molecular genetic studies show ADHD to be highly heritable, and other findings have recorded obstetric complications and psychosocial adversity as predisposing risk factors. Converging evidence from animal and human studies implicates the dysregulation of frontal-subcortical-cerebellar catecholaminergic circuits in the pathophysiology of ADHD, and molecular imaging studies suggest that abnormalities of the dopamine transporter lead to impaired neurotransmission. Studies during the past decade have shown the safety and effectiveness of new non-stimulant drugs and long-acting formulations of methylphenidate and amfetamine. Other investigations have also clarified the appropriate role of targeted psychosocial treatments in the context of ongoing pharmacotherapy." @default.
• W2914686075 created "2019-02-21" @default.
• W2914686075 creator A5024768165 @default.
• W2914686075 creator A5052145058 @default.
• W2914686075 date "2005-07-01" @default.
• W2914686075 modified "2023-10-09" @default.
• W2914686075 title "Attention-deficit hyperactivity disorder" @default.
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