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- W2914687567 endingPage "88" @default.
- W2914687567 startingPage "79" @default.
- W2914687567 abstract "The experimental validation of the existence of cancer stem cells (CSC) has had a significant impact on our understanding of the cellular mechanisms and signaling networks involved in the process of carcinogenesis and its progression. These findings provide insights into the critical role that tumor microenvironment and metabolism play in the acquisition of the drug resistance phenotype as well as provide potential targets for therapeutic exploitation. Here we briefly review the literature on the involvement of key signaling pathways such as Wnt/β-catenin, Notch, Hedgehog and STAT3 in the appearance of cancer cells with stem cells-like characteristics. In addition, we also highlight some of the recent therapeutic strategies used to target these pathways as well as approaches aiming to specifically target CSCs through their distinctive metabolic features." @default.
- W2914687567 created "2019-02-21" @default.
- W2914687567 creator A5016941505 @default.
- W2914687567 creator A5040753175 @default.
- W2914687567 creator A5083386422 @default.
- W2914687567 creator A5084717567 @default.
- W2914687567 date "2019-04-01" @default.
- W2914687567 modified "2023-10-06" @default.
- W2914687567 title "Understanding the cancer stem cell phenotype: A step forward in the therapeutic management of cancer" @default.
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