FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914688544> ?p ?o ?g. }

• W2914688544 endingPage "H991" @default.
• W2914688544 startingPage "H985" @default.
• W2914688544 abstract "The fetal myocardium is known to be sensitive to hemodynamic load, responding to systolic overload with cellular hypertrophy, proliferation, and accelerated maturation. However, the fetal cardiac growth response to primary volume overload is unknown. We hypothesized that increased venous return would stimulate fetal cardiomyocyte proliferation and terminal differentiation, particularly in the right ventricle (RV). Vascular catheters and pulmonary artery flow probes were implanted in 16 late-gestation fetal sheep: a right carotid artery-jugular vein (AV) fistula was surgically created in nine fetuses, and sham operations were performed on seven fetuses. Instrumented fetuses were studied for 1 wk before hearts were dissected for component analysis or cardiomyocyte dispersion for cellular measurements. Within 1 day of AV fistula creation, RV output was 20% higher in experimental than sham fetuses ( P < 0.0001). Circulating atrial natriuretic peptide levels were elevated fivefold in fetuses with an AV fistula ( P < 0.002). On the terminal day, RV-to-body weight ratios were 35% higher in the AV fistula group ( P < 0.05). Both left ventricular and RV cardiomyocytes grew longer in fetuses with an AV fistula ( P < 0.02). Cell cycle activity was depressed by >50% [significant in left ventricle ( P < 0.02), but not RV ( P < 0.054)]. Rates of terminal differentiation were unchanged. Based on these studies, we speculate that atrial natriuretic peptide suppressed fetal cardiomyocyte cell cycle activity. Unlike systolic overload, fetal diastolic load appears to drive myocyte enlargement, but not cardiomyocyte proliferation or maturation. These changes could predispose to RV dysfunction later in life. NEW & NOTEWORTHY Adaptation of the fetal heart to changes in cardiac load allows the fetus to maintain adequate blood flow to its systemic and placental circulations, which is necessary for the well-being of the fetus. Addition of arterial-venous fistula flow to existing venous return increased right ventricular stroke volume and output. The fetal heart compensated by cardiomyocyte elongation without accelerated cellular maturation, while cardiomyocyte proliferation decreased. Even transient volume overload in utero alters myocardial structure and cardiomyocyte endowment." @default.
• W2914688544 created "2019-02-21" @default.
• W2914688544 creator A5009816972 @default.
• W2914688544 creator A5013418670 @default.
• W2914688544 creator A5032890276 @default.
• W2914688544 creator A5041333266 @default.
• W2914688544 creator A5043735934 @default.
• W2914688544 creator A5084158432 @default.
• W2914688544 creator A5084957376 @default.
• W2914688544 date "2019-05-01" @default.
• W2914688544 modified "2023-10-15" @default.
• W2914688544 title "Right ventricular remodeling in response to volume overload in fetal sheep" @default.
• W2914688544 cites W1570238722 @default.
• W2914688544 cites W1588790451 @default.
• W2914688544 cites W1964247125 @default.
• W2914688544 cites W1968331622 @default.
• W2914688544 cites W1972426879 @default.
• W2914688544 cites W1985538533 @default.
• W2914688544 cites W1985866936 @default.
• W2914688544 cites W1989650369 @default.
• W2914688544 cites W1998095930 @default.
• W2914688544 cites W2019253521 @default.
• W2914688544 cites W2027791413 @default.
• W2914688544 cites W2033771516 @default.
• W2914688544 cites W2041878307 @default.
• W2914688544 cites W2057214603 @default.
• W2914688544 cites W2066823741 @default.
• W2914688544 cites W2070380907 @default.
• W2914688544 cites W2072122694 @default.
• W2914688544 cites W2073974662 @default.
• W2914688544 cites W2079973462 @default.
• W2914688544 cites W2081575341 @default.
• W2914688544 cites W2093902429 @default.
• W2914688544 cites W2095844332 @default.
• W2914688544 cites W2097166266 @default.
• W2914688544 cites W2104475665 @default.
• W2914688544 cites W2108883887 @default.
• W2914688544 cites W2109438818 @default.
• W2914688544 cites W2115732466 @default.
• W2914688544 cites W2119444687 @default.
• W2914688544 cites W2119989427 @default.
• W2914688544 cites W2122433471 @default.
• W2914688544 cites W2126455120 @default.
• W2914688544 cites W2132924014 @default.
• W2914688544 cites W2143080425 @default.
• W2914688544 cites W2145627955 @default.
• W2914688544 cites W2149925967 @default.
• W2914688544 cites W2154717545 @default.
• W2914688544 cites W2161149605 @default.
• W2914688544 cites W2162120425 @default.
• W2914688544 cites W2165230223 @default.
• W2914688544 cites W2185504415 @default.
• W2914688544 cites W2211186121 @default.
• W2914688544 cites W2223612093 @default.
• W2914688544 cites W2224491137 @default.
• W2914688544 cites W2334499091 @default.
• W2914688544 cites W2399213352 @default.
• W2914688544 cites W2415150720 @default.
• W2914688544 cites W2465704921 @default.
• W2914688544 cites W34655061 @default.
• W2914688544 cites W4237377124 @default.
• W2914688544 doi "https://doi.org/10.1152/ajpheart.00439.2018" @default.
• W2914688544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6580393" @default.
• W2914688544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30707615" @default.
• W2914688544 hasPublicationYear "2019" @default.
• W2914688544 type Work @default.
• W2914688544 sameAs 2914688544 @default.
• W2914688544 citedByCount "9" @default.
• W2914688544 countsByYear W29146885442021 @default.
• W2914688544 countsByYear W29146885442022 @default.
• W2914688544 crossrefType "journal-article" @default.
• W2914688544 hasAuthorship W2914688544A5009816972 @default.
• W2914688544 hasAuthorship W2914688544A5013418670 @default.
• W2914688544 hasAuthorship W2914688544A5032890276 @default.
• W2914688544 hasAuthorship W2914688544A5041333266 @default.
• W2914688544 hasAuthorship W2914688544A5043735934 @default.
• W2914688544 hasAuthorship W2914688544A5084158432 @default.
• W2914688544 hasAuthorship W2914688544A5084957376 @default.
• W2914688544 hasBestOaLocation W29146885441 @default.
• W2914688544 hasConcept C126322002 @default.
• W2914688544 hasConcept C134018914 @default.
• W2914688544 hasConcept C164705383 @default.
• W2914688544 hasConcept C167414201 @default.
• W2914688544 hasConcept C172680121 @default.
• W2914688544 hasConcept C24595384 @default.
• W2914688544 hasConcept C2778069365 @default.
• W2914688544 hasConcept C2778198053 @default.
• W2914688544 hasConcept C2778921608 @default.
• W2914688544 hasConcept C2779234561 @default.
• W2914688544 hasConcept C2780940725 @default.
• W2914688544 hasConcept C54355233 @default.
• W2914688544 hasConcept C57900726 @default.
• W2914688544 hasConcept C71924100 @default.
• W2914688544 hasConcept C84393581 @default.
• W2914688544 hasConcept C86803240 @default.
• W2914688544 hasConceptScore W2914688544C126322002 @default.
• W2914688544 hasConceptScore W2914688544C134018914 @default.
• W2914688544 hasConceptScore W2914688544C164705383 @default.

• next