FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914694770> ?p ?o ?g. }

• W2914694770 endingPage "111736" @default.
• W2914694770 startingPage "111736" @default.
• W2914694770 abstract "An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria. Extracts of different polarity and isolated constituents were tested in vitro for their antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and the chloroquine-sensitive strain P. falciparum NF54A19A, as well as for their cytotoxic effects againt MRC-5 cells (human lung fibroblasts). Extracts and fractions were evaluated in vivo against the chloroquine-resistant strain P. yoelii N67 and the chloroquine-sensitive strain P. berghei berghei ANKA. The aqueous extract, the 80% methanol extract and the alkaloid-enriched extract exhibited strong antiplasmodial activity against P. falciparum K1 with IC50 values < 10 µg/ml and against P. falciparum NF54 A19A with IC50 values < 0.02 µg/ml. In vivo against P. yoelii N67, at the highest oral dose of 400 mg/kg body weight, all extracts produced 70–73% chemosuppression, while against P. berghei berghei, more than 75% chemosuppression was observed. With regard to the isolated constituents, boonein was inactive in vitro against P. falciparum K-1 (IC50 > 64 µM), while echitamine, 6,7-seco-angustilobine B and β-amyrin exhibited moderate activity (IC50 < 30 µM). Against P. falciparum NF54 A19A, boonein was inactive (IC50 > 64 µM), while echitamine, 6,7-secoangustilobine and β-amyrin showed moderate IC50 values of 11.07, 21.26 and 40.70 µM, respectively. These results demonstrated that all extracts from A. congensis root bark possessed antiplasmodial activity in vitro and in vivo. They can be used as raw materials for the preparation of ameliorated remedies for the treatment of uncomplicated malaria. The observed antiplasmodial activity may be due in part to the presence of indole alkaloids." @default.
• W2914694770 created "2019-02-21" @default.
• W2914694770 creator A5003556333 @default.
• W2914694770 creator A5013501595 @default.
• W2914694770 creator A5025555014 @default.
• W2914694770 creator A5031737472 @default.
• W2914694770 creator A5034644354 @default.
• W2914694770 creator A5037284774 @default.
• W2914694770 creator A5054317264 @default.
• W2914694770 creator A5055821924 @default.
• W2914694770 creator A5058172988 @default.
• W2914694770 creator A5072547864 @default.
• W2914694770 creator A5082690777 @default.
• W2914694770 creator A5084892136 @default.
• W2914694770 date "2019-10-01" @default.
• W2914694770 modified "2023-09-27" @default.
• W2914694770 title "In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark" @default.
• W2914694770 cites W1995013536 @default.
• W2914694770 cites W2000407006 @default.
• W2914694770 cites W2007831277 @default.
• W2914694770 cites W2015361202 @default.
• W2914694770 cites W2040713555 @default.
• W2914694770 cites W2048198075 @default.
• W2914694770 cites W2048775251 @default.
• W2914694770 cites W2057611763 @default.
• W2914694770 cites W2058030191 @default.
• W2914694770 cites W2071225830 @default.
• W2914694770 cites W2078597534 @default.
• W2914694770 cites W2080317659 @default.
• W2914694770 cites W2086020572 @default.
• W2914694770 cites W2105668259 @default.
• W2914694770 cites W2132507895 @default.
• W2914694770 cites W2163446105 @default.
• W2914694770 cites W2168428623 @default.
• W2914694770 cites W2296263363 @default.
• W2914694770 cites W2460556627 @default.
• W2914694770 cites W2935893006 @default.
• W2914694770 cites W4233817843 @default.
• W2914694770 cites W656988569 @default.
• W2914694770 doi "https://doi.org/10.1016/j.jep.2019.02.019" @default.
• W2914694770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30763695" @default.
• W2914694770 hasPublicationYear "2019" @default.
• W2914694770 type Work @default.
• W2914694770 sameAs 2914694770 @default.
• W2914694770 citedByCount "14" @default.
• W2914694770 countsByYear W29146947702020 @default.
• W2914694770 countsByYear W29146947702021 @default.
• W2914694770 countsByYear W29146947702022 @default.
• W2914694770 countsByYear W29146947702023 @default.
• W2914694770 crossrefType "journal-article" @default.
• W2914694770 hasAuthorship W2914694770A5003556333 @default.
• W2914694770 hasAuthorship W2914694770A5013501595 @default.
• W2914694770 hasAuthorship W2914694770A5025555014 @default.
• W2914694770 hasAuthorship W2914694770A5031737472 @default.
• W2914694770 hasAuthorship W2914694770A5034644354 @default.
• W2914694770 hasAuthorship W2914694770A5037284774 @default.
• W2914694770 hasAuthorship W2914694770A5054317264 @default.
• W2914694770 hasAuthorship W2914694770A5055821924 @default.
• W2914694770 hasAuthorship W2914694770A5058172988 @default.
• W2914694770 hasAuthorship W2914694770A5072547864 @default.
• W2914694770 hasAuthorship W2914694770A5082690777 @default.
• W2914694770 hasAuthorship W2914694770A5084892136 @default.
• W2914694770 hasBestOaLocation W29146947702 @default.
• W2914694770 hasConcept C133446333 @default.
• W2914694770 hasConcept C150903083 @default.
• W2914694770 hasConcept C185592680 @default.
• W2914694770 hasConcept C18903297 @default.
• W2914694770 hasConcept C202751555 @default.
• W2914694770 hasConcept C203014093 @default.
• W2914694770 hasConcept C207001950 @default.
• W2914694770 hasConcept C2775867548 @default.
• W2914694770 hasConcept C2776486806 @default.
• W2914694770 hasConcept C2777237215 @default.
• W2914694770 hasConcept C2777425658 @default.
• W2914694770 hasConcept C2777667214 @default.
• W2914694770 hasConcept C2777752497 @default.
• W2914694770 hasConcept C2778048844 @default.
• W2914694770 hasConcept C2778371730 @default.
• W2914694770 hasConcept C2780007248 @default.
• W2914694770 hasConcept C55493867 @default.
• W2914694770 hasConcept C556039675 @default.
• W2914694770 hasConcept C59822182 @default.
• W2914694770 hasConcept C71924100 @default.
• W2914694770 hasConcept C86803240 @default.
• W2914694770 hasConcept C98274493 @default.
• W2914694770 hasConceptScore W2914694770C133446333 @default.
• W2914694770 hasConceptScore W2914694770C150903083 @default.
• W2914694770 hasConceptScore W2914694770C185592680 @default.
• W2914694770 hasConceptScore W2914694770C18903297 @default.
• W2914694770 hasConceptScore W2914694770C202751555 @default.
• W2914694770 hasConceptScore W2914694770C203014093 @default.
• W2914694770 hasConceptScore W2914694770C207001950 @default.
• W2914694770 hasConceptScore W2914694770C2775867548 @default.
• W2914694770 hasConceptScore W2914694770C2776486806 @default.
• W2914694770 hasConceptScore W2914694770C2777237215 @default.
• W2914694770 hasConceptScore W2914694770C2777425658 @default.
• W2914694770 hasConceptScore W2914694770C2777667214 @default.
• W2914694770 hasConceptScore W2914694770C2777752497 @default.

• next