Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914710139> ?p ?o ?g. }
- W2914710139 abstract "NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4+ and CD8+ T cells led to a significant decrease of NFΚBIA as the most downstream cytoplasmic NF-κB member, a reduced cell surface abundance of TCRA and CD3E, and to a reduction of T cell killing capacity. Inhibition of miR-34a caused an increase of NFΚBIA, TCRA, and CD3E. Notably, activation of CD4+ and CD8+ T cells entrails a gradual increase of miR-34a. Our results lend further support to a model with miR-34a as a central NF-κB regulator in T cells." @default.
- W2914710139 created "2019-02-21" @default.
- W2914710139 creator A5009201025 @default.
- W2914710139 creator A5016378595 @default.
- W2914710139 creator A5020280119 @default.
- W2914710139 creator A5020512308 @default.
- W2914710139 creator A5036565673 @default.
- W2914710139 creator A5040707127 @default.
- W2914710139 creator A5045126391 @default.
- W2914710139 creator A5054514348 @default.
- W2914710139 creator A5060657525 @default.
- W2914710139 creator A5074653262 @default.
- W2914710139 creator A5085594740 @default.
- W2914710139 creator A5085704368 @default.
- W2914710139 date "2019-01-18" @default.
- W2914710139 modified "2023-10-08" @default.
- W2914710139 title "miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling" @default.
- W2914710139 cites W1536643508 @default.
- W2914710139 cites W1640912622 @default.
- W2914710139 cites W1667352440 @default.
- W2914710139 cites W1679962258 @default.
- W2914710139 cites W1748495367 @default.
- W2914710139 cites W1849097877 @default.
- W2914710139 cites W1850752644 @default.
- W2914710139 cites W1945652054 @default.
- W2914710139 cites W1975336035 @default.
- W2914710139 cites W1984771273 @default.
- W2914710139 cites W1986245836 @default.
- W2914710139 cites W1997174802 @default.
- W2914710139 cites W2000433774 @default.
- W2914710139 cites W2000779612 @default.
- W2914710139 cites W2011211995 @default.
- W2914710139 cites W2016730049 @default.
- W2914710139 cites W2017635846 @default.
- W2914710139 cites W2027134998 @default.
- W2914710139 cites W2030166934 @default.
- W2914710139 cites W2032395102 @default.
- W2914710139 cites W2036770241 @default.
- W2914710139 cites W2040602022 @default.
- W2914710139 cites W2050096299 @default.
- W2914710139 cites W2052408923 @default.
- W2914710139 cites W2057322453 @default.
- W2914710139 cites W2063131697 @default.
- W2914710139 cites W2067419830 @default.
- W2914710139 cites W2068817531 @default.
- W2914710139 cites W2115452562 @default.
- W2914710139 cites W2116368522 @default.
- W2914710139 cites W2123079914 @default.
- W2914710139 cites W2128374908 @default.
- W2914710139 cites W2128584338 @default.
- W2914710139 cites W2133571578 @default.
- W2914710139 cites W2137734450 @default.
- W2914710139 cites W2139957642 @default.
- W2914710139 cites W2152256447 @default.
- W2914710139 cites W2155605501 @default.
- W2914710139 cites W2159874038 @default.
- W2914710139 cites W2161977998 @default.
- W2914710139 cites W2169545259 @default.
- W2914710139 cites W2171488801 @default.
- W2914710139 cites W2266501231 @default.
- W2914710139 cites W2299163506 @default.
- W2914710139 cites W2345035704 @default.
- W2914710139 cites W2461665465 @default.
- W2914710139 cites W2473107020 @default.
- W2914710139 cites W2581754481 @default.
- W2914710139 cites W2731520991 @default.
- W2914710139 cites W2801693446 @default.
- W2914710139 cites W4231836913 @default.
- W2914710139 cites W4253930413 @default.
- W2914710139 doi "https://doi.org/10.1038/s41419-018-1295-1" @default.
- W2914710139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6362007" @default.
- W2914710139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30718475" @default.
- W2914710139 hasPublicationYear "2019" @default.
- W2914710139 type Work @default.
- W2914710139 sameAs 2914710139 @default.
- W2914710139 citedByCount "54" @default.
- W2914710139 countsByYear W29147101392019 @default.
- W2914710139 countsByYear W29147101392020 @default.
- W2914710139 countsByYear W29147101392021 @default.
- W2914710139 countsByYear W29147101392022 @default.
- W2914710139 countsByYear W29147101392023 @default.
- W2914710139 crossrefType "journal-article" @default.
- W2914710139 hasAuthorship W2914710139A5009201025 @default.
- W2914710139 hasAuthorship W2914710139A5016378595 @default.
- W2914710139 hasAuthorship W2914710139A5020280119 @default.
- W2914710139 hasAuthorship W2914710139A5020512308 @default.
- W2914710139 hasAuthorship W2914710139A5036565673 @default.
- W2914710139 hasAuthorship W2914710139A5040707127 @default.
- W2914710139 hasAuthorship W2914710139A5045126391 @default.
- W2914710139 hasAuthorship W2914710139A5054514348 @default.
- W2914710139 hasAuthorship W2914710139A5060657525 @default.
- W2914710139 hasAuthorship W2914710139A5074653262 @default.
- W2914710139 hasAuthorship W2914710139A5085594740 @default.
- W2914710139 hasAuthorship W2914710139A5085704368 @default.
- W2914710139 hasBestOaLocation W29147101391 @default.
- W2914710139 hasConcept C104317684 @default.
- W2914710139 hasConcept C1491633281 @default.
- W2914710139 hasConcept C153911025 @default.
- W2914710139 hasConcept C185592680 @default.
- W2914710139 hasConcept C203014093 @default.