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- W2914738492 abstract "Myosins are actin-based molecular motor which are involved in various cellular processes including cell migration and endocytosis. More recently, both myosins and actin have been directly implicated in transcription through interactions with the three mammalian RNA polymerases, yet the precise function remains unknown. Myosin VI is over-expressed in breast, ovarian and prostate cancers, and when depleted inhibits proliferation and cell migration. We propose this is related to a direct link between Myosin VI and nuclear receptors, and its role in hormone-dependent gene transcription. We have identified that myosin VI is not only trafficked to the nucleus upon hormone stimulation, but it is also bound to promotor regions of hormone-responsive genes. Depletion of myosin VI leads to a loss of gene expression and subsequently an inhibition of proliferation. Using advanced single molecule microscopy techniques we have found that myosin VI regulates the assembly of RNA Polymerase II transcription factories in response to stimulation. We propose a model whereby myosin VI uses a load-induced anchoring ability to hold the complexes together as transcription occurs. In this manner, myosin VI uses its force-sensing properties to regulate hormone-induced gene expression." @default.
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- W2914738492 date "2019-02-01" @default.
- W2914738492 modified "2023-09-26" @default.
- W2914738492 title "Nuclear Myosin VI Regulates Estrogen Receptor Driven Gene Expression" @default.
- W2914738492 doi "https://doi.org/10.1016/j.bpj.2018.11.1151" @default.
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