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• W2914742735 abstract "<b><i>Background:</i></b> Recently, new devices using oscillometric cuff have been developed to derive central blood pressure (BP) waveform from brachial BP waveform. Late systolic pressure augmentation of central BP waveform is a marker of central hemodynamics. Mobil-O-Graph, a cuff-based oscillometric device, can assess central augmentation pressure (AP) together with central BP. Central AP measurement using the Mobil-O-Graph in the European population was reported to be associated with age and sex. However, factors influencing central AP in the Asian population have not been shown. <b><i>Objectives and Methods:</i></b> We enrolled 110 normotensive volunteers (50 men; age range, 21‒76 years). Central BP and AP were measured using the Mobil-O-Graph on the left arm with the subjects in the seated position after resting for at least 5 min. We compared central hemodynamics between the sexes. We investigated factors influencing central AP in uni- and multivariate linear regression analyses and age-related change in central AP using the Mobil-O-Graph in healthy Japanese individuals. <b><i>Results:</i></b> Central AP were lower in men than in women (5.5 ± 2.8 vs. 11.0 ± 4.7 mm Hg, <i>p</i> &#x3c; 0.001). The central AP in the total cohort was positively correlated with age (<i>r</i> = 0.325, <i>p</i> &#x3c; 0.001) and inversely correlated with height (<i>r</i> = −0.601, <i>p</i> &#x3c; 0.001) in the Pearson correlations. In multivariate regression analysis, the parameters influencing central AP (<i>R</i>² = 0.467) were age (β = 0.097, <i>p</i> &#x3c; 0.001), sex (β = −2.890, <i>p</i> = 0.010), and height (β = −0.153, <i>p</i> = 0.031). The central AP (10.0 ± 4.8 mm Hg) in the ≥50-year-old group significantly increased compared with those in the 20- to 39-year-old group (6.7 ± 4.2 mm Hg, <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> Age, sex, and height influenced central AP, as assessed using the Mobil-O-Graph. Age-related increase in central AP was observed in normotensive Japanese individuals. Brachial cuff-based waveform recordings using the Mobil-O-Graph are feasible for the estimation of central AP in the Asian population." @default.
• W2914742735 created "2019-02-21" @default.
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• W2914742735 date "2018-01-01" @default.
• W2914742735 modified "2023-09-26" @default.
• W2914742735 title "Cuff-Based Oscillometric Measurements of Central Hemodynamics: Factors Influencing Central Augmentation Pressure in Normotensive Japanese Individuals" @default.
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• W2914742735 doi "https://doi.org/10.1159/000496151" @default.
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