Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914745139> ?p ?o ?g. }
- W2914745139 endingPage "737" @default.
- W2914745139 startingPage "725" @default.
- W2914745139 abstract "Background Guidelines recommend treatment with 4–5 days of granulocyte colony-stimulating factor (G-CSF) for optimal donor peripheral blood progenitor cell (PBPC) mobilization followed by day 5 collection. Given that some autologous transplant recipients achieve adequate collection by day 4 and the possibility that some allogeneic donors may maximally mobilize PBPC before day 5, a feasibility study was performed evaluating day 4 allogeneic PBPC collection. Methods HLA-matched sibling donors underwent collection on day 4 of G-CSF for peripheral blood (PB) CD34+ counts ≥0.04 × 106/mL, otherwise they underwent collection on day 5. Those with inadequate collected CD34+ cells/kg recipient weight underwent repeat collection over 2 days. Transplant and PBPC characteristics and cost analysis were compared with a historical cohort collected on day 5 per our prior institutional algorithm. Results Of the 101 patient/donor pairs, 50 (49.5%) had adequate PBPC collection on day 4, with a median PB CD34+ cell count of 0.06 × 106/mL. Day 4 donors were more likely to develop bone pain and require analgesics. Median collected CD34+ count was significantly greater, whereas total nucleated, mononuclear and CD3+ cell counts were significantly lower, at time of transplant infusion for day 4 versus other collection cohorts. There were no significant differences in engraftment or graft-versus-host disease. Cost analysis revealed 6.7% direct cost savings for day 4 versus historical day 5 collection. Discussion Day 4 PB CD34+ threshold of ≥0.04 × 106/mL identified donors with high likelihood of adequate PBPC collection. Day 4 may be the optimal day of collection for healthy donors, without adverse effect on recipient transplant outcomes and with expected cost savings." @default.
- W2914745139 created "2019-02-21" @default.
- W2914745139 creator A5001304325 @default.
- W2914745139 creator A5001961836 @default.
- W2914745139 creator A5003102747 @default.
- W2914745139 creator A5009015962 @default.
- W2914745139 creator A5014707877 @default.
- W2914745139 creator A5047377510 @default.
- W2914745139 creator A5052079637 @default.
- W2914745139 creator A5064497727 @default.
- W2914745139 creator A5065926596 @default.
- W2914745139 creator A5070160044 @default.
- W2914745139 creator A5070277385 @default.
- W2914745139 creator A5082092102 @default.
- W2914745139 creator A5083412651 @default.
- W2914745139 creator A5091601805 @default.
- W2914745139 date "2019-07-01" @default.
- W2914745139 modified "2023-09-27" @default.
- W2914745139 title "Feasibility and cost analysis of day 4 granulocyte colony-stimulating factor mobilized peripheral blood progenitor cell collection from HLA-matched sibling donors" @default.
- W2914745139 cites W1501039723 @default.
- W2914745139 cites W1550454468 @default.
- W2914745139 cites W1940480041 @default.
- W2914745139 cites W1951664859 @default.
- W2914745139 cites W1983821870 @default.
- W2914745139 cites W2004644657 @default.
- W2914745139 cites W2016967633 @default.
- W2914745139 cites W2017926367 @default.
- W2914745139 cites W2019154801 @default.
- W2914745139 cites W2031830007 @default.
- W2914745139 cites W2045784916 @default.
- W2914745139 cites W2055638039 @default.
- W2914745139 cites W2061117723 @default.
- W2914745139 cites W2061718990 @default.
- W2914745139 cites W2067474391 @default.
- W2914745139 cites W2068219465 @default.
- W2914745139 cites W2071411325 @default.
- W2914745139 cites W2074644223 @default.
- W2914745139 cites W2074942153 @default.
- W2914745139 cites W2080350836 @default.
- W2914745139 cites W2084629831 @default.
- W2914745139 cites W2090761813 @default.
- W2914745139 cites W2096436308 @default.
- W2914745139 cites W2099413806 @default.
- W2914745139 cites W2113899987 @default.
- W2914745139 cites W2116128754 @default.
- W2914745139 cites W2121735943 @default.
- W2914745139 cites W2144411376 @default.
- W2914745139 cites W2145095230 @default.
- W2914745139 cites W2151081435 @default.
- W2914745139 cites W2153166372 @default.
- W2914745139 cites W2163320370 @default.
- W2914745139 cites W2166831434 @default.
- W2914745139 cites W2167328704 @default.
- W2914745139 cites W2168190553 @default.
- W2914745139 cites W2236173579 @default.
- W2914745139 cites W2332271831 @default.
- W2914745139 cites W2516841633 @default.
- W2914745139 cites W2555226387 @default.
- W2914745139 cites W2741070313 @default.
- W2914745139 cites W3024884870 @default.
- W2914745139 doi "https://doi.org/10.1016/j.jcyt.2019.04.001" @default.
- W2914745139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7219570" @default.
- W2914745139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31085121" @default.
- W2914745139 hasPublicationYear "2019" @default.
- W2914745139 type Work @default.
- W2914745139 sameAs 2914745139 @default.
- W2914745139 citedByCount "2" @default.
- W2914745139 countsByYear W29147451392020 @default.
- W2914745139 countsByYear W29147451392023 @default.
- W2914745139 crossrefType "journal-article" @default.
- W2914745139 hasAuthorship W2914745139A5001304325 @default.
- W2914745139 hasAuthorship W2914745139A5001961836 @default.
- W2914745139 hasAuthorship W2914745139A5003102747 @default.
- W2914745139 hasAuthorship W2914745139A5009015962 @default.
- W2914745139 hasAuthorship W2914745139A5014707877 @default.
- W2914745139 hasAuthorship W2914745139A5047377510 @default.
- W2914745139 hasAuthorship W2914745139A5052079637 @default.
- W2914745139 hasAuthorship W2914745139A5064497727 @default.
- W2914745139 hasAuthorship W2914745139A5065926596 @default.
- W2914745139 hasAuthorship W2914745139A5070160044 @default.
- W2914745139 hasAuthorship W2914745139A5070277385 @default.
- W2914745139 hasAuthorship W2914745139A5082092102 @default.
- W2914745139 hasAuthorship W2914745139A5083412651 @default.
- W2914745139 hasAuthorship W2914745139A5091601805 @default.
- W2914745139 hasBestOaLocation W29147451392 @default.
- W2914745139 hasConcept C10205521 @default.
- W2914745139 hasConcept C126322002 @default.
- W2914745139 hasConcept C137061746 @default.
- W2914745139 hasConcept C141071460 @default.
- W2914745139 hasConcept C201750760 @default.
- W2914745139 hasConcept C202751555 @default.
- W2914745139 hasConcept C2776694085 @default.
- W2914745139 hasConcept C2777371436 @default.
- W2914745139 hasConcept C2777767877 @default.
- W2914745139 hasConcept C28328180 @default.
- W2914745139 hasConcept C2911091166 @default.
- W2914745139 hasConcept C54355233 @default.
- W2914745139 hasConcept C55493867 @default.