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- W2914754918 abstract "Objective Arthritogenic alphaviruses, such as Ross River virus ( RRV ) and chikungunya virus ( CHIKV ), particularly affect joints of the extremities and can lead to debilitating and potentially chronic polyarthritis/polyarthralgia. The innate immune response of the host plays a crucial role in inducing proinflammatory host factors, leading to tissue destruction and bone loss in the joints. This study was performed to assess how the inhibition of interleukin‐1β ( IL ‐1β) signaling using the clinical rheumatoid arthritis drug anakinra influences bone loss in mice with arthritogenic alphavirus infections. Methods Mice (n = 5 per group) were infected with RRV or CHIKV and then treated with anakinra. Weight gain and disease severity were measured, tissue viral titers were determined, and histologic changes in joint tissues were assessed. Results Anakinra therapy reduced RRV ‐ and CHIKV ‐induced bone loss in this murine model ( P < 0.001 and P < 0.05, respectively). Histologic analysis of the knee joint showed that treatment with anakinra decreased epiphyseal growth plate thinning, loss of epiphyseal bone volume, and osteoclastogenesis in the tibia. Importantly, pharmacologic IL ‐1 receptor ( IL ‐1R) blockade did not improve other clinical features, including disease score, weight loss, or viremia. Conclusion The present findings suggest that anakinra therapy may reduce bone loss in experimental murine models of RRV and CHIKV . Further investigations are needed to assess the potential therapeutic benefits of anakinra in patients with arthritogenic alphavirus disease." @default.
- W2914754918 created "2019-02-21" @default.
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- W2914754918 date "2019-06-06" @default.
- W2914754918 modified "2023-10-15" @default.
- W2914754918 title "Inhibition of Interleukin‐1β Signaling by Anakinra Demonstrates a Critical Role of Bone Loss in Experimental Arthritogenic Alphavirus Infections" @default.
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- W2914754918 doi "https://doi.org/10.1002/art.40856" @default.
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