Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914756882> ?p ?o ?g. }
- W2914756882 endingPage "479" @default.
- W2914756882 startingPage "468" @default.
- W2914756882 abstract "Hodgkin Lymphoma (HL) is associated with deep microenvironment re-shaping and myeloid dysfunction. Given that only limited data are available regarding the role of Brentuximab Vedotin (BV) as single agent in transplant-naive relapsed/refractory (R/R) patients and its off-target effects on immune system, we evaluated the amount of regulatory T-cells (T-regs), myeloid-derived suppressor cells (MDSC) subpopulations, and their functional marker, serum arginase-1 (s-Arg-1), in peripheral blood of 15 consecutive R/R HL patients. After a median of four BV cycles, the overall response rate (complete response + partial response) was 47%, with 4 (27%) complete metabolic remissions. BV reduced the absolute number of three MDSC subtypes and s-Arg-1 levels. Patients with baseline s-Arg-1 ≥200 ng/ml had inferior progression-free survival at 36 months compared to those with low s-Arg-1. T-regs dysfunction was recovered by BV: absolute T-regs count was increased after treatment with BV, independently of metabolic response achieved, with a significant reduction of CD30+T-regs. Our data disclose off-target effects of BV in the microenvironment that could explain its deep and durable clinical efficacy." @default.
- W2914756882 created "2019-02-21" @default.
- W2914756882 creator A5015082674 @default.
- W2914756882 creator A5018769545 @default.
- W2914756882 creator A5030208971 @default.
- W2914756882 creator A5038163660 @default.
- W2914756882 creator A5060107199 @default.
- W2914756882 creator A5062765629 @default.
- W2914756882 creator A5065763544 @default.
- W2914756882 creator A5065852754 @default.
- W2914756882 creator A5070046619 @default.
- W2914756882 creator A5072417532 @default.
- W2914756882 creator A5089836876 @default.
- W2914756882 date "2019-02-15" @default.
- W2914756882 modified "2023-09-25" @default.
- W2914756882 title "Immune off‐target effects of Brentuximab Vedotin in relapsed/refractory Hodgkin Lymphoma" @default.
- W2914756882 cites W1978849352 @default.
- W2914756882 cites W1989111278 @default.
- W2914756882 cites W1998668726 @default.
- W2914756882 cites W2000210989 @default.
- W2914756882 cites W2011118089 @default.
- W2914756882 cites W2049622226 @default.
- W2914756882 cites W2056093991 @default.
- W2914756882 cites W2058662175 @default.
- W2914756882 cites W2073306952 @default.
- W2914756882 cites W2075727474 @default.
- W2914756882 cites W2104065243 @default.
- W2914756882 cites W2105565011 @default.
- W2914756882 cites W2108273635 @default.
- W2914756882 cites W2111070506 @default.
- W2914756882 cites W2119722488 @default.
- W2914756882 cites W2124587380 @default.
- W2914756882 cites W2133201432 @default.
- W2914756882 cites W2150379694 @default.
- W2914756882 cites W2153794129 @default.
- W2914756882 cites W2168543296 @default.
- W2914756882 cites W2339885660 @default.
- W2914756882 cites W2341089209 @default.
- W2914756882 cites W2520864380 @default.
- W2914756882 cites W2620486493 @default.
- W2914756882 cites W2772084440 @default.
- W2914756882 cites W2774310048 @default.
- W2914756882 cites W2784654265 @default.
- W2914756882 cites W2803000479 @default.
- W2914756882 cites W2887875907 @default.
- W2914756882 cites W2889446347 @default.
- W2914756882 doi "https://doi.org/10.1111/bjh.15801" @default.
- W2914756882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30768678" @default.
- W2914756882 hasPublicationYear "2019" @default.
- W2914756882 type Work @default.
- W2914756882 sameAs 2914756882 @default.
- W2914756882 citedByCount "16" @default.
- W2914756882 countsByYear W29147568822019 @default.
- W2914756882 countsByYear W29147568822020 @default.
- W2914756882 countsByYear W29147568822021 @default.
- W2914756882 countsByYear W29147568822022 @default.
- W2914756882 countsByYear W29147568822023 @default.
- W2914756882 crossrefType "journal-article" @default.
- W2914756882 hasAuthorship W2914756882A5015082674 @default.
- W2914756882 hasAuthorship W2914756882A5018769545 @default.
- W2914756882 hasAuthorship W2914756882A5030208971 @default.
- W2914756882 hasAuthorship W2914756882A5038163660 @default.
- W2914756882 hasAuthorship W2914756882A5060107199 @default.
- W2914756882 hasAuthorship W2914756882A5062765629 @default.
- W2914756882 hasAuthorship W2914756882A5065763544 @default.
- W2914756882 hasAuthorship W2914756882A5065852754 @default.
- W2914756882 hasAuthorship W2914756882A5070046619 @default.
- W2914756882 hasAuthorship W2914756882A5072417532 @default.
- W2914756882 hasAuthorship W2914756882A5089836876 @default.
- W2914756882 hasBestOaLocation W29147568821 @default.
- W2914756882 hasConcept C126322002 @default.
- W2914756882 hasConcept C142424586 @default.
- W2914756882 hasConcept C143998085 @default.
- W2914756882 hasConcept C203014093 @default.
- W2914756882 hasConcept C2776107976 @default.
- W2914756882 hasConcept C2778191690 @default.
- W2914756882 hasConcept C2779338263 @default.
- W2914756882 hasConcept C2992779791 @default.
- W2914756882 hasConcept C71924100 @default.
- W2914756882 hasConcept C86803240 @default.
- W2914756882 hasConcept C87355193 @default.
- W2914756882 hasConcept C8891405 @default.
- W2914756882 hasConceptScore W2914756882C126322002 @default.
- W2914756882 hasConceptScore W2914756882C142424586 @default.
- W2914756882 hasConceptScore W2914756882C143998085 @default.
- W2914756882 hasConceptScore W2914756882C203014093 @default.
- W2914756882 hasConceptScore W2914756882C2776107976 @default.
- W2914756882 hasConceptScore W2914756882C2778191690 @default.
- W2914756882 hasConceptScore W2914756882C2779338263 @default.
- W2914756882 hasConceptScore W2914756882C2992779791 @default.
- W2914756882 hasConceptScore W2914756882C71924100 @default.
- W2914756882 hasConceptScore W2914756882C86803240 @default.
- W2914756882 hasConceptScore W2914756882C87355193 @default.
- W2914756882 hasConceptScore W2914756882C8891405 @default.
- W2914756882 hasFunder F4320322965 @default.
- W2914756882 hasFunder F4320324043 @default.
- W2914756882 hasIssue "3" @default.
- W2914756882 hasLocation W29147568821 @default.