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- W2914760109 abstract "Calophyllum is a pan-tropical genus belongs to the Guttiferae family and known by Malay local folks as ‘bintangor’. There has been a continual interest to further investigate the phytochemicals of Calophyllum species since this genus is a rich source of active secondary metabolites such as coumarin, chromanone carboxylic acid and flavonoid which showed anti-HIV, cytotoxicity and antimicrobial properties. In this study, phytochemicals studies on the barks and leaves of Calophyllum incrassatum M.R. Henderson & Wyatt-Smith were carried out. Cold extraction method was employed by using dichloromethane, ethyl acetate and methanol to give the respective crude extracts. Four new 4-substituted coumarins, namely, incrassamarin A, B, C and D were successfully isolated from the dichloromethane extracts of the barks and leaves by size-exclusion recycling HPLC and column chromatography techniques. The structures of the compounds were elucidated by spectral analysis including NMR, IR, MS and X-ray crystallography. The compounds were tested for their cytotoxic activity towards human breast adenocarcinoma (MCF-7) and human non-small cell lung carcinoma (A-549) cell lines by MTT assay and α-glucosidase enzymatic inhibitory activity. Incrassamarin A displayed cytotoxic activity against A-549 cell lines with IC50 87.71 mg/ml and showed inhibition towards α-glucosidase enzymatic activity with IC50 93.25 mM." @default.
- W2914760109 created "2019-02-21" @default.
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- W2914760109 date "2018-01-01" @default.
- W2914760109 modified "2023-09-28" @default.
- W2914760109 title "Isolation, cytotoxic and alpha-glucosidase inhibitory activities of new coumarins from calophyllum incrassatum" @default.
- W2914760109 hasPublicationYear "2018" @default.
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