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• W2914763463 abstract "Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution. Adaptive laboratory evolution experiments in Escherichia coli show that the pseudogene efeU can be repaired to restore the bacterium’s iron uptake system, demonstrating that pseudogenes may serve as an ‘adaptive repertoire’ of selectable traits." @default.
• W2914763463 created "2019-02-21" @default.
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• W2914763463 date "2019-01-28" @default.
• W2914763463 modified "2023-10-15" @default.
• W2914763463 title "Pseudogene repair driven by selection pressure applied in experimental evolution" @default.
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• W2914763463 doi "https://doi.org/10.1038/s41564-018-0340-2" @default.
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• W2914763463 hasPublicationYear "2019" @default.
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