Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914775462> ?p ?o ?g. }
- W2914775462 endingPage "69" @default.
- W2914775462 startingPage "61" @default.
- W2914775462 abstract "Antibiotic resistance in pathogens is a growing threat to human health. Of particular concern is resistance to carbapenem, which is an antimicrobial agent listed as critically important by the World Health Organization. With the global spread of carbapenem-resistant organisms, there is an urgent need for new treatment options. Shewanella algae is an emerging pathogen found in marine environments throughout the world that has increasing resistance to carbapenem. The organism is also a possible antibiotic resistance reservoir in humans and in its natural habitat. The development of CRISPR/Cas9-based methods has enabled precise genetic manipulation. A number of attempts have been made to knock out resistance genes in various organisms. The study used a single plasmid containing CRISPR/Cas9 and recE/recT recombinase to reverse an antibiotic-resistant phenotype in S. algae and showed blaOXA-55-like gene is essential for the carbapenem resistance. This result demonstrates a potential validation strategy for functional genome annotation in S. algae." @default.
- W2914775462 created "2019-02-21" @default.
- W2914775462 creator A5006795311 @default.
- W2914775462 creator A5012534391 @default.
- W2914775462 creator A5015253235 @default.
- W2914775462 creator A5021042434 @default.
- W2914775462 creator A5063076942 @default.
- W2914775462 creator A5091279923 @default.
- W2914775462 date "2019-07-01" @default.
- W2914775462 modified "2023-10-17" @default.
- W2914775462 title "Reversal of carbapenem-resistance in Shewanella algae by CRISPR/Cas9 genome editing" @default.
- W2914775462 cites W1534386309 @default.
- W2914775462 cites W1580639168 @default.
- W2914775462 cites W1870558638 @default.
- W2914775462 cites W1874122563 @default.
- W2914775462 cites W1884874540 @default.
- W2914775462 cites W1931722540 @default.
- W2914775462 cites W1948947423 @default.
- W2914775462 cites W1955626595 @default.
- W2914775462 cites W1978129709 @default.
- W2914775462 cites W1981185465 @default.
- W2914775462 cites W1990045669 @default.
- W2914775462 cites W1990820295 @default.
- W2914775462 cites W2000046950 @default.
- W2914775462 cites W2040883911 @default.
- W2914775462 cites W2052874074 @default.
- W2914775462 cites W2053030084 @default.
- W2914775462 cites W2066991387 @default.
- W2914775462 cites W2087634668 @default.
- W2914775462 cites W2090211843 @default.
- W2914775462 cites W2098907512 @default.
- W2914775462 cites W2099837668 @default.
- W2914775462 cites W2100154032 @default.
- W2914775462 cites W2102754164 @default.
- W2914775462 cites W2109773039 @default.
- W2914775462 cites W2119633529 @default.
- W2914775462 cites W2120263648 @default.
- W2914775462 cites W2120503144 @default.
- W2914775462 cites W2123196886 @default.
- W2914775462 cites W2123547995 @default.
- W2914775462 cites W2123677996 @default.
- W2914775462 cites W2132412592 @default.
- W2914775462 cites W2143999510 @default.
- W2914775462 cites W2153385829 @default.
- W2914775462 cites W2168054819 @default.
- W2914775462 cites W2182456467 @default.
- W2914775462 cites W2194181707 @default.
- W2914775462 cites W2202810729 @default.
- W2914775462 cites W2263818957 @default.
- W2914775462 cites W2488780863 @default.
- W2914775462 cites W2517681744 @default.
- W2914775462 cites W2551152889 @default.
- W2914775462 cites W2555328493 @default.
- W2914775462 cites W2567492774 @default.
- W2914775462 cites W2585631566 @default.
- W2914775462 cites W2601025347 @default.
- W2914775462 cites W2733630357 @default.
- W2914775462 cites W2803813675 @default.
- W2914775462 cites W2896832238 @default.
- W2914775462 cites W2950354111 @default.
- W2914775462 doi "https://doi.org/10.1016/j.jare.2019.01.011" @default.
- W2914775462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6374997" @default.
- W2914775462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30809393" @default.
- W2914775462 hasPublicationYear "2019" @default.
- W2914775462 type Work @default.
- W2914775462 sameAs 2914775462 @default.
- W2914775462 citedByCount "18" @default.
- W2914775462 countsByYear W29147754622019 @default.
- W2914775462 countsByYear W29147754622020 @default.
- W2914775462 countsByYear W29147754622021 @default.
- W2914775462 countsByYear W29147754622022 @default.
- W2914775462 countsByYear W29147754622023 @default.
- W2914775462 crossrefType "journal-article" @default.
- W2914775462 hasAuthorship W2914775462A5006795311 @default.
- W2914775462 hasAuthorship W2914775462A5012534391 @default.
- W2914775462 hasAuthorship W2914775462A5015253235 @default.
- W2914775462 hasAuthorship W2914775462A5021042434 @default.
- W2914775462 hasAuthorship W2914775462A5063076942 @default.
- W2914775462 hasAuthorship W2914775462A5091279923 @default.
- W2914775462 hasBestOaLocation W29147754621 @default.
- W2914775462 hasConcept C104317684 @default.
- W2914775462 hasConcept C132455925 @default.
- W2914775462 hasConcept C132533263 @default.
- W2914775462 hasConcept C141231307 @default.
- W2914775462 hasConcept C144501496 @default.
- W2914775462 hasConcept C22744801 @default.
- W2914775462 hasConcept C2776685102 @default.
- W2914775462 hasConcept C2778824058 @default.
- W2914775462 hasConcept C501593827 @default.
- W2914775462 hasConcept C523546767 @default.
- W2914775462 hasConcept C54355233 @default.
- W2914775462 hasConcept C70721500 @default.
- W2914775462 hasConcept C86803240 @default.
- W2914775462 hasConcept C89423630 @default.
- W2914775462 hasConcept C94665300 @default.
- W2914775462 hasConcept C98108389 @default.
- W2914775462 hasConceptScore W2914775462C104317684 @default.
- W2914775462 hasConceptScore W2914775462C132455925 @default.