Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914775791> ?p ?o ?g. }
- W2914775791 endingPage "2128" @default.
- W2914775791 startingPage "2117" @default.
- W2914775791 abstract "Service members during military actions or combat training are exposed frequently to primary blast generated by explosive weaponry. The majority of military-related neurotrauma are classified as mild and designated as “invisible injuries” that are prevalent during current conflicts. While the previous experimental blast injury studies using moderate- to high-intensity exposures focused mainly on gross and microscopic neuropathology, our previous studies have shown that low-intensity blast (LIB) exposures resulted in nanoscale subcellular myelin and mitochondrial damages and subsequent behavioral disorders in the absence of gross or detectable cellular damage. In this study, we used transmission electron microscopy to delineate the LIB effects at the ultrastructural level specifically focusing on the neuron perikaryon, axons, and synapses in the cortex and hippocampus of mice at seven and 30 days post-injury (DPI). We found dysmorphic dark neuronal perikaryon and “cytoplasmic aeration” of dendritic processes, as well as increased microtubular fragmentation of the myelinated axons along with biochemically measured elevated tau/phosphorylated tau/Aβ levels. The number of cortical excitatory synapses decreased along with a compensatory increase of the post-synaptic density (PSD) thickness both at seven and 30 DPI, while the amount of hippocampal CA1 synapses increased with the reduced PSD thickness. In addition, we observed a significant increase in protein levels of PSD95 and synaptophysin mainly at seven DPI indicating potential synaptic reorganization. These results demonstrated that a single LIB exposure can lead to ultrastructural brain injury with accompanying multi-focal neuronal organelle alterations. This pre-clinical study provides key insights into disease pathogenesis related to primary blast exposure." @default.
- W2914775791 created "2019-02-21" @default.
- W2914775791 creator A5009228103 @default.
- W2914775791 creator A5016563724 @default.
- W2914775791 creator A5029138795 @default.
- W2914775791 creator A5037443223 @default.
- W2914775791 creator A5039862810 @default.
- W2914775791 creator A5044329647 @default.
- W2914775791 creator A5054439871 @default.
- W2914775791 creator A5058793400 @default.
- W2914775791 creator A5066396102 @default.
- W2914775791 creator A5067459467 @default.
- W2914775791 creator A5070915730 @default.
- W2914775791 creator A5080838669 @default.
- W2914775791 creator A5090002703 @default.
- W2914775791 date "2019-07-01" @default.
- W2914775791 modified "2023-10-18" @default.
- W2914775791 title "Multi-Focal Neuronal Ultrastructural Abnormalities and Synaptic Alterations in Mice after Low-Intensity Blast Exposure" @default.
- W2914775791 cites W1487695731 @default.
- W2914775791 cites W1509460845 @default.
- W2914775791 cites W1520386485 @default.
- W2914775791 cites W1607531254 @default.
- W2914775791 cites W1694984064 @default.
- W2914775791 cites W181333104 @default.
- W2914775791 cites W1849720006 @default.
- W2914775791 cites W1923767489 @default.
- W2914775791 cites W1964169664 @default.
- W2914775791 cites W1966466547 @default.
- W2914775791 cites W1973311433 @default.
- W2914775791 cites W1982571807 @default.
- W2914775791 cites W1984354039 @default.
- W2914775791 cites W1984652813 @default.
- W2914775791 cites W1984800913 @default.
- W2914775791 cites W1994824032 @default.
- W2914775791 cites W2007804566 @default.
- W2914775791 cites W2017613746 @default.
- W2914775791 cites W2025478064 @default.
- W2914775791 cites W2026747237 @default.
- W2914775791 cites W2030868131 @default.
- W2914775791 cites W2045732157 @default.
- W2914775791 cites W2056197197 @default.
- W2914775791 cites W2061749458 @default.
- W2914775791 cites W2064426755 @default.
- W2914775791 cites W2066159876 @default.
- W2914775791 cites W2098747537 @default.
- W2914775791 cites W2100193772 @default.
- W2914775791 cites W2103081565 @default.
- W2914775791 cites W2105985886 @default.
- W2914775791 cites W2115129913 @default.
- W2914775791 cites W2116838881 @default.
- W2914775791 cites W2117672006 @default.
- W2914775791 cites W2137096994 @default.
- W2914775791 cites W2147516066 @default.
- W2914775791 cites W2153279852 @default.
- W2914775791 cites W2158113697 @default.
- W2914775791 cites W2160383565 @default.
- W2914775791 cites W2162679859 @default.
- W2914775791 cites W2168735204 @default.
- W2914775791 cites W2179947625 @default.
- W2914775791 cites W2191765325 @default.
- W2914775791 cites W2245968033 @default.
- W2914775791 cites W23520400 @default.
- W2914775791 cites W2488339761 @default.
- W2914775791 cites W2507454459 @default.
- W2914775791 cites W2511795741 @default.
- W2914775791 cites W2528514032 @default.
- W2914775791 cites W2540247148 @default.
- W2914775791 cites W2565619752 @default.
- W2914775791 cites W2734272739 @default.
- W2914775791 cites W2738010656 @default.
- W2914775791 cites W2755958735 @default.
- W2914775791 cites W2762375112 @default.
- W2914775791 cites W2773063462 @default.
- W2914775791 cites W2787949518 @default.
- W2914775791 cites W2792580789 @default.
- W2914775791 cites W2886637495 @default.
- W2914775791 cites W2897729047 @default.
- W2914775791 cites W4242516469 @default.
- W2914775791 cites W882405344 @default.
- W2914775791 doi "https://doi.org/10.1089/neu.2018.6260" @default.
- W2914775791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30667346" @default.
- W2914775791 hasPublicationYear "2019" @default.
- W2914775791 type Work @default.
- W2914775791 sameAs 2914775791 @default.
- W2914775791 citedByCount "13" @default.
- W2914775791 countsByYear W29147757912020 @default.
- W2914775791 countsByYear W29147757912021 @default.
- W2914775791 countsByYear W29147757912022 @default.
- W2914775791 countsByYear W29147757912023 @default.
- W2914775791 crossrefType "journal-article" @default.
- W2914775791 hasAuthorship W2914775791A5009228103 @default.
- W2914775791 hasAuthorship W2914775791A5016563724 @default.
- W2914775791 hasAuthorship W2914775791A5029138795 @default.
- W2914775791 hasAuthorship W2914775791A5037443223 @default.
- W2914775791 hasAuthorship W2914775791A5039862810 @default.
- W2914775791 hasAuthorship W2914775791A5044329647 @default.
- W2914775791 hasAuthorship W2914775791A5054439871 @default.
- W2914775791 hasAuthorship W2914775791A5058793400 @default.