FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914779810> ?p ?o ?g. }

• W2914779810 endingPage "245" @default.
• W2914779810 startingPage "233" @default.
• W2914779810 abstract "Oral drug delivery is natural, most acceptable and desirable route for nearly all drugs, but many drugs like NSAIDs when delivered by this route cause gastrointestinal irritation, gastric bleeding, ulcers, and many undesirable effects which limits their usage by oral delivery. Moreover, it is almost impossible to control the release of a drug in a targeted location in body. We developed thermo-responsive chitosan-co-poly(N-isopropyl-acrylamide) injectable hydrogel as an alternative for the gastro-protective and controlled delivery of loxoprofen sodium as a model drug. A free radical polymerization technique was used to synthesize thermo-responsive hydrogel by cross-linking chitosan HCl with NIPAAM using glutaraldehyde as cross-linker. Confirmation of crosslinked hydrogel structure was done by Fourier transform infrared spectra (FTIR). The thermal stability of hydrogel was confirmed through thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The scanning electron microscopy (SEM) was performed to evaluate the structural morphology of cross-linked hydrogel. To evaluate the rheological behavior of hydrogel with increasing temperature, rheological study was performed. Swelling and in vitro drug release studies were carried out under various temperature and pH conditions. The swelling study revealed that maximum swelling was observed at low pH (pH 1.2) and low temperature (25 °C) compared to the high range of pH and temperature and it resulted in quick release of the drug. The high range of pH (7.4) and temperature (37 °C) however caused controlled release of the drug. The in vivo evaluation of the developed hydrogel in rabbits demonstrated the controlled release behavior of fabricated system." @default.
• W2914779810 created "2019-02-21" @default.
• W2914779810 creator A5029913208 @default.
• W2914779810 creator A5031239861 @default.
• W2914779810 creator A5032222232 @default.
• W2914779810 creator A5036288303 @default.
• W2914779810 creator A5038116256 @default.
• W2914779810 creator A5041108459 @default.
• W2914779810 creator A5049959334 @default.
• W2914779810 creator A5053396193 @default.
• W2914779810 creator A5068965772 @default.
• W2914779810 creator A5084315682 @default.
• W2914779810 creator A5088165594 @default.
• W2914779810 date "2019-05-01" @default.
• W2914779810 modified "2023-10-16" @default.
• W2914779810 title "Chitosan based thermosensitive injectable hydrogels for controlled delivery of loxoprofen: development, characterization and in-vivo evaluation" @default.
• W2914779810 cites W1877301297 @default.
• W2914779810 cites W1884467795 @default.
• W2914779810 cites W1928090083 @default.
• W2914779810 cites W1972212476 @default.
• W2914779810 cites W1973025159 @default.
• W2914779810 cites W1982443012 @default.
• W2914779810 cites W1990738807 @default.
• W2914779810 cites W1994539251 @default.
• W2914779810 cites W2002503814 @default.
• W2914779810 cites W2006179840 @default.
• W2914779810 cites W2006631374 @default.
• W2914779810 cites W2006743062 @default.
• W2914779810 cites W2009636777 @default.
• W2914779810 cites W2011626775 @default.
• W2914779810 cites W2012827771 @default.
• W2914779810 cites W2012956740 @default.
• W2914779810 cites W2013991689 @default.
• W2914779810 cites W2015862311 @default.
• W2914779810 cites W2018931797 @default.
• W2914779810 cites W2022986809 @default.
• W2914779810 cites W2024306244 @default.
• W2914779810 cites W2030841219 @default.
• W2914779810 cites W2031596413 @default.
• W2914779810 cites W2031650970 @default.
• W2914779810 cites W2034169886 @default.
• W2914779810 cites W2035187113 @default.
• W2914779810 cites W2042244179 @default.
• W2914779810 cites W2043226523 @default.
• W2914779810 cites W2043725137 @default.
• W2914779810 cites W2044003429 @default.
• W2914779810 cites W2050827327 @default.
• W2914779810 cites W2060239018 @default.
• W2914779810 cites W2073650315 @default.
• W2914779810 cites W2074149078 @default.
• W2914779810 cites W2081280388 @default.
• W2914779810 cites W2081628222 @default.
• W2914779810 cites W2087384428 @default.
• W2914779810 cites W2091676885 @default.
• W2914779810 cites W2092528623 @default.
• W2914779810 cites W2094569428 @default.
• W2914779810 cites W2109245704 @default.
• W2914779810 cites W2109793406 @default.
• W2914779810 cites W2169883750 @default.
• W2914779810 cites W2345966168 @default.
• W2914779810 cites W2512861901 @default.
• W2914779810 cites W2529221006 @default.
• W2914779810 cites W2617967744 @default.
• W2914779810 cites W2766634431 @default.
• W2914779810 cites W2766908530 @default.
• W2914779810 cites W2766940634 @default.
• W2914779810 cites W2792031821 @default.
• W2914779810 doi "https://doi.org/10.1016/j.ijbiomac.2019.02.031" @default.
• W2914779810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30738157" @default.
• W2914779810 hasPublicationYear "2019" @default.
• W2914779810 type Work @default.
• W2914779810 sameAs 2914779810 @default.
• W2914779810 citedByCount "55" @default.
• W2914779810 countsByYear W29147798102019 @default.
• W2914779810 countsByYear W29147798102020 @default.
• W2914779810 countsByYear W29147798102021 @default.
• W2914779810 countsByYear W29147798102022 @default.
• W2914779810 countsByYear W29147798102023 @default.
• W2914779810 crossrefType "journal-article" @default.
• W2914779810 hasAuthorship W2914779810A5029913208 @default.
• W2914779810 hasAuthorship W2914779810A5031239861 @default.
• W2914779810 hasAuthorship W2914779810A5032222232 @default.
• W2914779810 hasAuthorship W2914779810A5036288303 @default.
• W2914779810 hasAuthorship W2914779810A5038116256 @default.
• W2914779810 hasAuthorship W2914779810A5041108459 @default.
• W2914779810 hasAuthorship W2914779810A5049959334 @default.
• W2914779810 hasAuthorship W2914779810A5053396193 @default.
• W2914779810 hasAuthorship W2914779810A5068965772 @default.
• W2914779810 hasAuthorship W2914779810A5084315682 @default.
• W2914779810 hasAuthorship W2914779810A5088165594 @default.
• W2914779810 hasConcept C108586683 @default.
• W2914779810 hasConcept C121332964 @default.
• W2914779810 hasConcept C127413603 @default.
• W2914779810 hasConcept C150903083 @default.
• W2914779810 hasConcept C159985019 @default.
• W2914779810 hasConcept C160892712 @default.
• W2914779810 hasConcept C163588942 @default.
• W2914779810 hasConcept C171250308 @default.

• next