FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914784579> ?p ?o ?g. }

• W2914784579 endingPage "3545" @default.
• W2914784579 startingPage "3539" @default.
• W2914784579 abstract "Phosphorylated proteins play important roles in the pathogenesis of Alzheimer’s disease (AD). The most abundant constituent in AD’s brain deposit is the amyloid-β40 peptide (Aβ40). Based on it, the degree of phosphorylated Aβ40 in body fluids (e.g., cerebrospinal fluid, CSF), which is defined by the ratio of phosphorylated Aβ40 to total Aβ40 (pAβ40/tAβ40), is anticipated to be an index for early diagnosis of AD. The major challenge in pAβ40/tAβ40 detection is the large concentration difference between two Aβ40 forms in the real samples, which usually requires multichannel equipment and complicated detection process. In this paper, we revealed the unexpected close affinities of the anti-Aβ40 antibody to Aβ40 (40.2 nM–1) and to pAβ40 (42.3 nM–1). Based on it, a convenient coimmunocapture and electrochemical quantitation of tAβ40 and pAβ40 was achieved on an anti-Aβ40 antibody immobilized Au electrode (anti-Aβ40/Au). Once Aβ40 and pAβ40 were synchronously captured on the anti-Aβ40/Au electrode, the tAβ40 levels in CSF samples were quantified with electrochemical impedance spectroscopy. With the signal amplification from Cd2+/Ti4+-functionalized titanium phosphate nanospheres (Cd2+/Ti4+@TiP) which was selective conjugated to pAβ40, concentrations of low abundant pAβ40 as low as 1 fM were readily measured by square wave voltammetry. Our results reveal that despite the concentrations of tAβ40 and pAβ40 fluctuate in each individual case, the concentration ratios of pAβ40/tAβ40 in CSF samples from AD patients are significant larger than those from healthy donors. It demonstrates that the degree of phosphorylated Aβ40 is hopeful to be an effective index for evaluating the AD progress and improving the accuracy of clinic AD diagnosis." @default.
• W2914784579 created "2019-02-21" @default.
• W2914784579 creator A5011164088 @default.
• W2914784579 creator A5012834626 @default.
• W2914784579 creator A5027242949 @default.
• W2914784579 creator A5027324747 @default.
• W2914784579 creator A5029940522 @default.
• W2914784579 creator A5034112897 @default.
• W2914784579 creator A5049993618 @default.
• W2914784579 creator A5075177355 @default.
• W2914784579 creator A5089245987 @default.
• W2914784579 date "2019-02-06" @default.
• W2914784579 modified "2023-10-16" @default.
• W2914784579 title "Coimmunocapture and Electrochemical Quantitation of Total and Phosphorylated Amyloid-β₄₀ Monomers" @default.
• W2914784579 cites W1500504466 @default.
• W2914784579 cites W1597946562 @default.
• W2914784579 cites W1792975234 @default.
• W2914784579 cites W1900793573 @default.
• W2914784579 cites W1939416134 @default.
• W2914784579 cites W1987797109 @default.
• W2914784579 cites W1995272223 @default.
• W2914784579 cites W2008262280 @default.
• W2914784579 cites W2040973042 @default.
• W2914784579 cites W2046295572 @default.
• W2914784579 cites W2052749726 @default.
• W2914784579 cites W2053577054 @default.
• W2914784579 cites W2058586745 @default.
• W2914784579 cites W2096410114 @default.
• W2914784579 cites W2126607520 @default.
• W2914784579 cites W2130061671 @default.
• W2914784579 cites W2135370282 @default.
• W2914784579 cites W2149450071 @default.
• W2914784579 cites W2154315446 @default.
• W2914784579 cites W2154735761 @default.
• W2914784579 cites W2159689528 @default.
• W2914784579 cites W2280427474 @default.
• W2914784579 cites W2287205331 @default.
• W2914784579 cites W2341682650 @default.
• W2914784579 cites W2502992426 @default.
• W2914784579 cites W2510814953 @default.
• W2914784579 cites W2571390534 @default.
• W2914784579 cites W2600914407 @default.
• W2914784579 cites W2620705941 @default.
• W2914784579 cites W2781632922 @default.
• W2914784579 cites W2783674487 @default.
• W2914784579 cites W2804736405 @default.
• W2914784579 cites W2806214600 @default.
• W2914784579 cites W2890727658 @default.
• W2914784579 doi "https://doi.org/10.1021/acs.analchem.8b05307" @default.
• W2914784579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30724072" @default.
• W2914784579 hasPublicationYear "2019" @default.
• W2914784579 type Work @default.
• W2914784579 sameAs 2914784579 @default.
• W2914784579 citedByCount "20" @default.
• W2914784579 countsByYear W29147845792019 @default.
• W2914784579 countsByYear W29147845792020 @default.
• W2914784579 countsByYear W29147845792022 @default.
• W2914784579 countsByYear W29147845792023 @default.
• W2914784579 crossrefType "journal-article" @default.
• W2914784579 hasAuthorship W2914784579A5011164088 @default.
• W2914784579 hasAuthorship W2914784579A5012834626 @default.
• W2914784579 hasAuthorship W2914784579A5027242949 @default.
• W2914784579 hasAuthorship W2914784579A5027324747 @default.
• W2914784579 hasAuthorship W2914784579A5029940522 @default.
• W2914784579 hasAuthorship W2914784579A5034112897 @default.
• W2914784579 hasAuthorship W2914784579A5049993618 @default.
• W2914784579 hasAuthorship W2914784579A5075177355 @default.
• W2914784579 hasAuthorship W2914784579A5089245987 @default.
• W2914784579 hasConcept C119128265 @default.
• W2914784579 hasConcept C11960822 @default.
• W2914784579 hasConcept C126322002 @default.
• W2914784579 hasConcept C13965031 @default.
• W2914784579 hasConcept C147789679 @default.
• W2914784579 hasConcept C166940927 @default.
• W2914784579 hasConcept C17525397 @default.
• W2914784579 hasConcept C178790620 @default.
• W2914784579 hasConcept C185592680 @default.
• W2914784579 hasConcept C2777869211 @default.
• W2914784579 hasConcept C2779281246 @default.
• W2914784579 hasConcept C2779651940 @default.
• W2914784579 hasConcept C43617362 @default.
• W2914784579 hasConcept C521977710 @default.
• W2914784579 hasConcept C52859227 @default.
• W2914784579 hasConcept C55493867 @default.
• W2914784579 hasConcept C7040849 @default.
• W2914784579 hasConcept C71924100 @default.
• W2914784579 hasConceptScore W2914784579C119128265 @default.
• W2914784579 hasConceptScore W2914784579C11960822 @default.
• W2914784579 hasConceptScore W2914784579C126322002 @default.
• W2914784579 hasConceptScore W2914784579C13965031 @default.
• W2914784579 hasConceptScore W2914784579C147789679 @default.
• W2914784579 hasConceptScore W2914784579C166940927 @default.
• W2914784579 hasConceptScore W2914784579C17525397 @default.
• W2914784579 hasConceptScore W2914784579C178790620 @default.
• W2914784579 hasConceptScore W2914784579C185592680 @default.
• W2914784579 hasConceptScore W2914784579C2777869211 @default.
• W2914784579 hasConceptScore W2914784579C2779281246 @default.
• W2914784579 hasConceptScore W2914784579C2779651940 @default.

• next