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- W2914790147 endingPage "369" @default.
- W2914790147 startingPage "361" @default.
- W2914790147 abstract "Until recently, a one‐drug‐fits‐all model was applied to every patient diagnosed with the same condition. But not every condition is the same, and this has led to many cases of ineffective treatment. Pharmacogenetics is increasingly used to stratify patients for precision medicine treatments, for instance, the UGT1A1*28 polymorphism as a dosage indicator for the use of irinotecan as well as epidermal growth factor receptor (EGFR) immunohistochemistry and KRAS Proto‐Oncogene ( KRAS ) exon 2 mutation tests for determining the likelihood of treatment response to cetuximab or panitumumab treatment in metastatic colorectal cancer (CRC). The other molecular subtypes, such as KRAS exon 3/4, B‐Raf Proto‐Oncogene, NRAF , PIK3CA , and PETN , were also reported as potential new pharmacogenetic targets for the current and the newly discovered anticancer drugs. In addition to next‐generation sequencing (NGS), primary tumor cells for in vivo and in vitro drug screening, imaging biomarker 3′‐Deoxy‐3′‐18F‐fluorothymidine positron emission tomography, and circulating tumor DNA (ctDNA) detection methods are being developed and may represent the future direction of precision medicine. This review will discuss the current environment of precision medicine, including clinically approved targeted therapies, the latest potential therapeutic agents, and the ongoing pharmacogenetic trials for CRC patients." @default.
- W2914790147 created "2019-02-21" @default.
- W2914790147 creator A5012053345 @default.
- W2914790147 date "2019-02-08" @default.
- W2914790147 modified "2023-09-30" @default.
- W2914790147 title "Precision treatment in colorectal cancer: Now and the future" @default.
- W2914790147 cites W1488490809 @default.
- W2914790147 cites W1503485936 @default.
- W2914790147 cites W1539753726 @default.
- W2914790147 cites W1572739876 @default.
- W2914790147 cites W1774948393 @default.
- W2914790147 cites W1878663564 @default.
- W2914790147 cites W1893566975 @default.
- W2914790147 cites W1940241680 @default.
- W2914790147 cites W1964463923 @default.
- W2914790147 cites W1968014316 @default.
- W2914790147 cites W1968209756 @default.
- W2914790147 cites W1976443390 @default.
- W2914790147 cites W1984328540 @default.
- W2914790147 cites W1994943514 @default.
- W2914790147 cites W2016620494 @default.
- W2914790147 cites W2017650189 @default.
- W2914790147 cites W2020642365 @default.
- W2914790147 cites W2021622287 @default.
- W2914790147 cites W2027735722 @default.
- W2914790147 cites W2031102273 @default.
- W2914790147 cites W2034301901 @default.
- W2914790147 cites W2034338421 @default.
- W2914790147 cites W2036353825 @default.
- W2914790147 cites W2041798076 @default.
- W2914790147 cites W2043071900 @default.
- W2914790147 cites W2056003066 @default.
- W2914790147 cites W2058951658 @default.
- W2914790147 cites W2062109911 @default.
- W2914790147 cites W2081238655 @default.
- W2914790147 cites W2085717627 @default.
- W2914790147 cites W2094268545 @default.
- W2914790147 cites W2095822339 @default.
- W2914790147 cites W2096195999 @default.
- W2914790147 cites W2096523159 @default.
- W2914790147 cites W2101711321 @default.
- W2914790147 cites W2103789431 @default.
- W2914790147 cites W2104580737 @default.
- W2914790147 cites W2111851685 @default.
- W2914790147 cites W2112570485 @default.
- W2914790147 cites W2113720307 @default.
- W2914790147 cites W2115735904 @default.
- W2914790147 cites W2121700962 @default.
- W2914790147 cites W2121847974 @default.
- W2914790147 cites W2123965006 @default.
- W2914790147 cites W2128507784 @default.
- W2914790147 cites W2129255527 @default.
- W2914790147 cites W2129880070 @default.
- W2914790147 cites W2133045939 @default.
- W2914790147 cites W2134519717 @default.
- W2914790147 cites W2137833632 @default.
- W2914790147 cites W2137910932 @default.
- W2914790147 cites W2137964922 @default.
- W2914790147 cites W2141801755 @default.
- W2914790147 cites W2145310954 @default.
- W2914790147 cites W2146037607 @default.
- W2914790147 cites W2147834058 @default.
- W2914790147 cites W2152414695 @default.
- W2914790147 cites W2155492044 @default.
- W2914790147 cites W2155893084 @default.
- W2914790147 cites W2157016650 @default.
- W2914790147 cites W2158863975 @default.
- W2914790147 cites W2160373161 @default.
- W2914790147 cites W2160550688 @default.
- W2914790147 cites W2160801283 @default.
- W2914790147 cites W2161682775 @default.
- W2914790147 cites W2167539263 @default.
- W2914790147 cites W2168083201 @default.
- W2914790147 cites W2170454539 @default.
- W2914790147 cites W2174633205 @default.
- W2914790147 cites W2293809486 @default.
- W2914790147 cites W2301536592 @default.
- W2914790147 cites W2342114595 @default.
- W2914790147 cites W2343129507 @default.
- W2914790147 cites W2346168782 @default.
- W2914790147 cites W2407394352 @default.
- W2914790147 cites W242040007 @default.
- W2914790147 cites W2462620900 @default.
- W2914790147 cites W2464728687 @default.
- W2914790147 cites W2467230081 @default.
- W2914790147 cites W2470575266 @default.
- W2914790147 cites W2511788166 @default.
- W2914790147 cites W2519894360 @default.
- W2914790147 cites W2520046580 @default.
- W2914790147 cites W2529369798 @default.
- W2914790147 cites W2573152477 @default.
- W2914790147 cites W2576899770 @default.
- W2914790147 cites W2579749207 @default.
- W2914790147 cites W2589528865 @default.
- W2914790147 cites W2601380465 @default.
- W2914790147 cites W2605536675 @default.
- W2914790147 cites W2606171824 @default.
- W2914790147 cites W2766700932 @default.