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• W2914796622 abstract "Deep brain stimulation (DBS) has emerged as an efficacious modality for the treatment of medically refractory neuropsychiatric diseases. Traditional DBS approaches have used a single pair of bilateral leads to treat diseases with relatively well-defined disease networks and targets [ [1] Williams N.R. Foote K.D. Okun M.S. STN vs. GPi deep brain stimulation: translating the rematch into clinical practice. Mov Disord Clin Pract. 2014; 1: 24-35 Crossref PubMed Scopus (88) Google Scholar ]. However, the optimal approach for Gilles de la Tourette syndrome (GTS) has yet to be determined. GTS is complicated by having more than 4 proposed DBS targets for the motor system and common comorbidities including major depressive depression (MDD) and obsessive-compulsive disorder (OCD) [ [2] Porta M. Saleh C. Zekaj E. Zanaboni Dina C. Bona A.R. Servello D. Why so many deep brain stimulation targets in Tourette's syndrome? Toward a broadening of the definition of the syndrome. J Neural Transm. 2016; 123 (Austria): 785-790 Crossref PubMed Scopus (19) Google Scholar , [3] Servello D. Zekaj E. Saleh C. Lange N. Porta M. Deep brain stimulation in Gilles de la Tourette syndrome: what does the future hold? A cohort of 48 patients. Neurosurgery. 2016; 78: 91-100 Crossref PubMed Scopus (38) Google Scholar ]. Networks implicated in these diseases involve targets including the centromedian-parafascicular complex (CM), the ventral capsule/ventral striatum (VC/VS), the anterior limb of the internal capsule (ALIC), and the nucleus accumbens (NAc) [ [4] Bergfeld I.O. Mantione M. Hoogendoorn M.L. Ruhe H.G. Notten P. van Laarhoven J. et al. Deep brain stimulation of the ventral anterior limb of the internal capsule for treatment-resistant depression: a randomized clinical trial. JAMA Psychiatry. 2016; 73: 456-464 Crossref PubMed Scopus (185) Google Scholar ]. Clinical management is further complicated in patients with refractory pain secondary to motor tics who may be managed with opiates and develop dependence on these substances [ [5] Krauss J.K. Jankovic J. Severe motor tics causing cervical myelopathy in Tourette's syndrome. Mov Disord. 1996; 11: 563-566 Crossref PubMed Scopus (82) Google Scholar ]. DBS of the NAc has been shown to ameliorate consumption of substances of abuse including alcohol, nicotine, and heroin, adding further support for multi-targeted DBS approaches [ [6] Kuhn J. Moller M. Treppmann J.F. Bartsch C. Lenartz D. Gruendler T.O. et al. Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction. Mol Psychiatr. 2014; 19 (England): 145-146 Crossref PubMed Scopus (89) Google Scholar ]." @default.
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• W2914796622 date "2019-05-01" @default.
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• W2914796622 title "Robust clinical benefit of multi-target deep brain stimulation for treatment of Gilles de la Tourette syndrome and its comorbidities" @default.
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• W2914796622 doi "https://doi.org/10.1016/j.brs.2019.02.026" @default.
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