Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914800753> ?p ?o ?g. }
- W2914800753 abstract "Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments. Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical models aiming to resurface the degenerated cartilage. In early-phase clinical trials, intra-articular (IA) administration of MSCs leads to pain reduction and cartilage protection or healing. However, the consistent lack of engraftment indicates that the observed effect is delivered through a hit-and-run mechanism, by a temporal release of paracrine molecules. MSCs express a variety of chemokines and cytokines that aid in repair of degraded tissue, restoration of normal tissue metabolism and, most importantly, counteracting inflammation. Secretion of therapeutic factors is increased upon licensing by inflammatory signals or apoptosis, induced by the host immune system. Trophic effectors are released as soluble molecules or carried by extracellular vesicles (ECVs). This review provides an overview of the functions and mechanisms of MSC-secreted molecules found to be upregulated in models of OA, whether using in vitro or in vivo models." @default.
- W2914800753 created "2019-02-21" @default.
- W2914800753 creator A5009576604 @default.
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- W2914800753 creator A5048040610 @default.
- W2914800753 creator A5068137387 @default.
- W2914800753 creator A5076064769 @default.
- W2914800753 date "2019-01-29" @default.
- W2914800753 modified "2023-10-15" @default.
- W2914800753 title "Mesenchymal Stem Cell Therapy for Osteoarthritis: The Critical Role of the Cell Secretome" @default.
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