Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914845353> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2914845353 abstract "Breast cancer is a major disease posing many therapeutic and societal challenges. The major problem remains the diversity of the disease. Breast cancers are divided in several distinct subtypes, but the specific mechanisms involved in each subtype are not understood. We apply advanced network medicine techniques to the analysis of transcriptomics data of several breast cancer cell lines. We show that different subtypes are characterized by highly heterogeneous pathway activity. Using the overlap between differentially expressed genes and drug-induced expression changes, we present candidate drugs for repurposing. Furthermore, we find different active subnetworks across the subtypes, regulated by distinct transcription factors. All these results are made available via a user-friendly portal at http://phenome.manchester.ac.uk/breastcancer/." @default.
- W2914845353 created "2019-02-21" @default.
- W2914845353 creator A5030168322 @default.
- W2914845353 creator A5032957076 @default.
- W2914845353 creator A5046134592 @default.
- W2914845353 date "2018-12-01" @default.
- W2914845353 modified "2023-10-16" @default.
- W2914845353 title "A meta-analysis portal for human breast cancer transcriptomics data: BreastCancerVis" @default.
- W2914845353 cites W1964904043 @default.
- W2914845353 cites W1993170943 @default.
- W2914845353 cites W2020541351 @default.
- W2914845353 cites W2043904301 @default.
- W2914845353 cites W2073111188 @default.
- W2914845353 cites W2106391842 @default.
- W2914845353 cites W2107060225 @default.
- W2914845353 cites W2110490515 @default.
- W2914845353 cites W2110578052 @default.
- W2914845353 cites W2120842170 @default.
- W2914845353 cites W2130019368 @default.
- W2914845353 cites W2140239055 @default.
- W2914845353 cites W2140593657 @default.
- W2914845353 cites W2160450758 @default.
- W2914845353 cites W2169353806 @default.
- W2914845353 cites W2179438025 @default.
- W2914845353 cites W2180138021 @default.
- W2914845353 cites W2344480160 @default.
- W2914845353 cites W2489003193 @default.
- W2914845353 cites W2616922646 @default.
- W2914845353 cites W2617077704 @default.
- W2914845353 cites W2732292771 @default.
- W2914845353 cites W2795548516 @default.
- W2914845353 cites W2885994867 @default.
- W2914845353 cites W402335930 @default.
- W2914845353 doi "https://doi.org/10.1109/bibm.2018.8621315" @default.
- W2914845353 hasPublicationYear "2018" @default.
- W2914845353 type Work @default.
- W2914845353 sameAs 2914845353 @default.
- W2914845353 citedByCount "0" @default.
- W2914845353 crossrefType "proceedings-article" @default.
- W2914845353 hasAuthorship W2914845353A5030168322 @default.
- W2914845353 hasAuthorship W2914845353A5032957076 @default.
- W2914845353 hasAuthorship W2914845353A5046134592 @default.
- W2914845353 hasBestOaLocation W29148453532 @default.
- W2914845353 hasConcept C103637391 @default.
- W2914845353 hasConcept C104317684 @default.
- W2914845353 hasConcept C121608353 @default.
- W2914845353 hasConcept C126322002 @default.
- W2914845353 hasConcept C143998085 @default.
- W2914845353 hasConcept C150194340 @default.
- W2914845353 hasConcept C162317418 @default.
- W2914845353 hasConcept C18903297 @default.
- W2914845353 hasConcept C2779134260 @default.
- W2914845353 hasConcept C2780035454 @default.
- W2914845353 hasConcept C519536355 @default.
- W2914845353 hasConcept C530470458 @default.
- W2914845353 hasConcept C54355233 @default.
- W2914845353 hasConcept C60644358 @default.
- W2914845353 hasConcept C70721500 @default.
- W2914845353 hasConcept C71924100 @default.
- W2914845353 hasConcept C86803240 @default.
- W2914845353 hasConcept C98274493 @default.
- W2914845353 hasConceptScore W2914845353C103637391 @default.
- W2914845353 hasConceptScore W2914845353C104317684 @default.
- W2914845353 hasConceptScore W2914845353C121608353 @default.
- W2914845353 hasConceptScore W2914845353C126322002 @default.
- W2914845353 hasConceptScore W2914845353C143998085 @default.
- W2914845353 hasConceptScore W2914845353C150194340 @default.
- W2914845353 hasConceptScore W2914845353C162317418 @default.
- W2914845353 hasConceptScore W2914845353C18903297 @default.
- W2914845353 hasConceptScore W2914845353C2779134260 @default.
- W2914845353 hasConceptScore W2914845353C2780035454 @default.
- W2914845353 hasConceptScore W2914845353C519536355 @default.
- W2914845353 hasConceptScore W2914845353C530470458 @default.
- W2914845353 hasConceptScore W2914845353C54355233 @default.
- W2914845353 hasConceptScore W2914845353C60644358 @default.
- W2914845353 hasConceptScore W2914845353C70721500 @default.
- W2914845353 hasConceptScore W2914845353C71924100 @default.
- W2914845353 hasConceptScore W2914845353C86803240 @default.
- W2914845353 hasConceptScore W2914845353C98274493 @default.
- W2914845353 hasLocation W29148453531 @default.
- W2914845353 hasLocation W29148453532 @default.
- W2914845353 hasLocation W29148453533 @default.
- W2914845353 hasOpenAccess W2914845353 @default.
- W2914845353 hasPrimaryLocation W29148453531 @default.
- W2914845353 hasRelatedWork W2096405787 @default.
- W2914845353 hasRelatedWork W2142339805 @default.
- W2914845353 hasRelatedWork W2734327577 @default.
- W2914845353 hasRelatedWork W2755049937 @default.
- W2914845353 hasRelatedWork W2883844422 @default.
- W2914845353 hasRelatedWork W3114112383 @default.
- W2914845353 hasRelatedWork W3144103640 @default.
- W2914845353 hasRelatedWork W4281726759 @default.
- W2914845353 hasRelatedWork W4307501484 @default.
- W2914845353 hasRelatedWork W4360839275 @default.
- W2914845353 isParatext "false" @default.
- W2914845353 isRetracted "false" @default.
- W2914845353 magId "2914845353" @default.
- W2914845353 workType "article" @default.