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- W2914854889 endingPage "503" @default.
- W2914854889 startingPage "483" @default.
- W2914854889 abstract "Endothelial cell (EC) metabolism is important for health and disease. Metabolic pathways, such as glycolysis, fatty acid oxidation, and amino acid metabolism, determine vasculature formation. These metabolic pathways have different roles in securing the production of energy and biomass and the maintenance of redox homeostasis in vascular migratory tip cells, proliferating stalk cells, and quiescent phalanx cells, respectively. Emerging evidence demonstrates that perturbation of EC metabolism results in EC dysfunction and vascular pathologies. Here, we summarize recent insights into EC metabolic pathways and their deregulation in vascular diseases. We further discuss the therapeutic implications of targeting EC metabolism in various pathologies." @default.
- W2914854889 created "2019-02-21" @default.
- W2914854889 creator A5047152113 @default.
- W2914854889 creator A5056307986 @default.
- W2914854889 creator A5077886490 @default.
- W2914854889 date "2019-02-10" @default.
- W2914854889 modified "2023-10-13" @default.
- W2914854889 title "Metabolic Pathways Fueling the Endothelial Cell Drive" @default.
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