FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914866952> ?p ?o ?g. }

• W2914866952 endingPage "28" @default.
• W2914866952 startingPage "21" @default.
• W2914866952 abstract "Human metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA known to be highly expressed in several tumors. In colorectal cancer (CRC), MALAT1 promotes cell proliferation, metastasis, and invasion in vitro and in vivo. This study aimed to investigate the effect of MALAT1 on the proliferation, migration, and drug sensitivity of CRC cells in vitro and in vivo and the mechanisms involved therein. We observed increased expression of MALAT1 in six CRC cell lines compared to that in normal cells, suggesting its involvement in CRC progression. Downregulation of MALAT1 inhibited cell migration and induced apoptosis in vitro and inhibited tumor growth and metastasis in nude mice. Furthermore, MALAT1 silencing downregulated the expression of ATP-binding cassette transporters (ABC), breast cancer resistance protein (BCRP), and multi-drug resistance proteins including MDR1 and MRP1, resulting in decreased resistance of cancer cells to 5-FU. In addition, the metastasis and invasion of HCT-116 and HCT-116/5-FU cells were regulated via targeting miR-20b-5p. Based on these observations, we infer that inhibition of MALAT1 suppressed CRC progression and metastasis and improved the sensitivity of cancer cells to 5-FU. The present study proposes a new direction to investigate the molecular mechanisms underlying the invasion and metastasis of CRC, whereby the interaction between MALAT1 and miR-20b-5p could be a novel therapeutic target for CRC." @default.
• W2914866952 created "2019-02-21" @default.
• W2914866952 creator A5009976386 @default.
• W2914866952 creator A5016291949 @default.
• W2914866952 creator A5055377723 @default.
• W2914866952 creator A5070498523 @default.
• W2914866952 creator A5073634698 @default.
• W2914866952 creator A5078200297 @default.
• W2914866952 creator A5080155540 @default.
• W2914866952 creator A5089373620 @default.
• W2914866952 date "2019-05-01" @default.
• W2914866952 modified "2023-10-17" @default.
• W2914866952 title "Inhibition of MALAT1 reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer" @default.
• W2914866952 cites W1520425169 @default.
• W2914866952 cites W1542426682 @default.
• W2914866952 cites W1863095676 @default.
• W2914866952 cites W1971716536 @default.
• W2914866952 cites W1988795813 @default.
• W2914866952 cites W1999746344 @default.
• W2914866952 cites W2003748625 @default.
• W2914866952 cites W2007015770 @default.
• W2914866952 cites W2007942290 @default.
• W2914866952 cites W2010226341 @default.
• W2914866952 cites W2023563217 @default.
• W2914866952 cites W2024227785 @default.
• W2914866952 cites W2025944270 @default.
• W2914866952 cites W2033184210 @default.
• W2914866952 cites W2040350615 @default.
• W2914866952 cites W2049247618 @default.
• W2914866952 cites W2051357113 @default.
• W2914866952 cites W2068728873 @default.
• W2914866952 cites W2073079990 @default.
• W2914866952 cites W2087528029 @default.
• W2914866952 cites W2088629757 @default.
• W2914866952 cites W2107685513 @default.
• W2914866952 cites W2110303120 @default.
• W2914866952 cites W2116168949 @default.
• W2914866952 cites W2124198704 @default.
• W2914866952 cites W2129555794 @default.
• W2914866952 cites W2139790154 @default.
• W2914866952 cites W2147287621 @default.
• W2914866952 cites W2150757282 @default.
• W2914866952 cites W2190279695 @default.
• W2914866952 cites W2274595380 @default.
• W2914866952 cites W2328724428 @default.
• W2914866952 cites W2512058578 @default.
• W2914866952 cites W2550073770 @default.
• W2914866952 cites W2758756987 @default.
• W2914866952 cites W2791404959 @default.
• W2914866952 cites W2793182311 @default.
• W2914866952 cites W4231404431 @default.
• W2914866952 doi "https://doi.org/10.1016/j.cellsig.2019.01.013" @default.
• W2914866952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30716387" @default.
• W2914866952 hasPublicationYear "2019" @default.
• W2914866952 type Work @default.
• W2914866952 sameAs 2914866952 @default.
• W2914866952 citedByCount "38" @default.
• W2914866952 countsByYear W29148669522019 @default.
• W2914866952 countsByYear W29148669522020 @default.
• W2914866952 countsByYear W29148669522021 @default.
• W2914866952 countsByYear W29148669522022 @default.
• W2914866952 countsByYear W29148669522023 @default.
• W2914866952 crossrefType "journal-article" @default.
• W2914866952 hasAuthorship W2914866952A5009976386 @default.
• W2914866952 hasAuthorship W2914866952A5016291949 @default.
• W2914866952 hasAuthorship W2914866952A5055377723 @default.
• W2914866952 hasAuthorship W2914866952A5070498523 @default.
• W2914866952 hasAuthorship W2914866952A5073634698 @default.
• W2914866952 hasAuthorship W2914866952A5078200297 @default.
• W2914866952 hasAuthorship W2914866952A5080155540 @default.
• W2914866952 hasAuthorship W2914866952A5089373620 @default.
• W2914866952 hasConcept C104317684 @default.
• W2914866952 hasConcept C119056186 @default.
• W2914866952 hasConcept C121608353 @default.
• W2914866952 hasConcept C126322002 @default.
• W2914866952 hasConcept C127561419 @default.
• W2914866952 hasConcept C150903083 @default.
• W2914866952 hasConcept C207001950 @default.
• W2914866952 hasConcept C2779013556 @default.
• W2914866952 hasConcept C2779134362 @default.
• W2914866952 hasConcept C2781182431 @default.
• W2914866952 hasConcept C502942594 @default.
• W2914866952 hasConcept C526805850 @default.
• W2914866952 hasConcept C54355233 @default.
• W2914866952 hasConcept C55493867 @default.
• W2914866952 hasConcept C62112901 @default.
• W2914866952 hasConcept C62203573 @default.
• W2914866952 hasConcept C71924100 @default.
• W2914866952 hasConcept C86803240 @default.
• W2914866952 hasConcept C96232424 @default.
• W2914866952 hasConceptScore W2914866952C104317684 @default.
• W2914866952 hasConceptScore W2914866952C119056186 @default.
• W2914866952 hasConceptScore W2914866952C121608353 @default.
• W2914866952 hasConceptScore W2914866952C126322002 @default.
• W2914866952 hasConceptScore W2914866952C127561419 @default.
• W2914866952 hasConceptScore W2914866952C150903083 @default.
• W2914866952 hasConceptScore W2914866952C207001950 @default.
• W2914866952 hasConceptScore W2914866952C2779013556 @default.

• next