FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914867711> ?p ?o ?g. }

• W2914867711 endingPage "296" @default.
• W2914867711 startingPage "287" @default.
• W2914867711 abstract "Reconstruction of bone defects with the use of biomaterials based on hydroxyapatite (HAp) has been a popular approach in medicine and dentistry. Most often the process of new bone formation is analyzed with the focus only on the region of the reconstructed defect. The effects of the therapy on distant organs have been rarely reported in the literature, especially not in synergy with the exposure to other bioactive chemicals. In this study, reconstruction of the mandibular bone in vivo using poly-lactide-co-glycolide-coated HAp (HAp/PLGA) nanoparticles was monitored with a simultaneous histopathological analysis of distant organs, specifically kidney and liver parenchyma. Heavy metals are among the most prominent environmental pollutants and have a high affinity for the crystal lattice of HAp, where they get incorporated by replacing calcium ions. Lead (Pb) and cadmium (Cd) are two such metals that can be found in food, water and air, but are most commonly present in cigarette smoke, the frequent contaminant of hospital settings in the developing world. The influence of their presence in the repaired bone on the content of calcium (Ca) in the reconstructed bone defect was analyzed, along with the histopathological changes in liver and kidneys. A study performed on 24 female Wistar rats demonstrated that the reconstruction of mandibular bone defects using HAp/PLGA particles induced an increase in the content of Ca in the newly created bone without causing any pathological changes to the liver and the kidneys. The presence of Pb and Cd in the defects reconstructed with HAp/PLGA nanoparticles impeded the regenerative process and led to a severe and irreversible damage to the liver and kidney parenchyma." @default.
• W2914867711 created "2019-02-21" @default.
• W2914867711 creator A5017106775 @default.
• W2914867711 creator A5017624327 @default.
• W2914867711 creator A5047769327 @default.
• W2914867711 creator A5087741085 @default.
• W2914867711 date "2019-01-01" @default.
• W2914867711 modified "2023-10-15" @default.
• W2914867711 title "Effects of hydroxyapatite@poly-lactide-<i>co</i>-glycolide nanoparticles combined with Pb and Cd on liver and kidney parenchyma after the reconstruction of mandibular bone defects" @default.
• W2914867711 cites W1846776373 @default.
• W2914867711 cites W196562560 @default.
• W2914867711 cites W1981393228 @default.
• W2914867711 cites W1981714526 @default.
• W2914867711 cites W1985758090 @default.
• W2914867711 cites W1986247883 @default.
• W2914867711 cites W1986544341 @default.
• W2914867711 cites W2000952331 @default.
• W2914867711 cites W2007394108 @default.
• W2914867711 cites W2009176936 @default.
• W2914867711 cites W2009398968 @default.
• W2914867711 cites W2014739271 @default.
• W2914867711 cites W2016161594 @default.
• W2914867711 cites W2017264962 @default.
• W2914867711 cites W2022434891 @default.
• W2914867711 cites W2025603365 @default.
• W2914867711 cites W2027725351 @default.
• W2914867711 cites W2030199225 @default.
• W2914867711 cites W2032923564 @default.
• W2914867711 cites W2056983151 @default.
• W2914867711 cites W2058265392 @default.
• W2914867711 cites W2062093409 @default.
• W2914867711 cites W2065198065 @default.
• W2914867711 cites W2070517488 @default.
• W2914867711 cites W2071522072 @default.
• W2914867711 cites W2073822753 @default.
• W2914867711 cites W2076770618 @default.
• W2914867711 cites W2079177198 @default.
• W2914867711 cites W2079291378 @default.
• W2914867711 cites W2087032263 @default.
• W2914867711 cites W2116431726 @default.
• W2914867711 cites W2132873662 @default.
• W2914867711 cites W2137140584 @default.
• W2914867711 cites W2140444916 @default.
• W2914867711 cites W2151420872 @default.
• W2914867711 cites W2151699770 @default.
• W2914867711 cites W2165449700 @default.
• W2914867711 cites W2177944947 @default.
• W2914867711 cites W2178235082 @default.
• W2914867711 cites W2178867550 @default.
• W2914867711 cites W2266423485 @default.
• W2914867711 cites W2318700814 @default.
• W2914867711 cites W2346233401 @default.
• W2914867711 cites W2394800184 @default.
• W2914867711 cites W2478923561 @default.
• W2914867711 cites W2593089115 @default.
• W2914867711 cites W2601309215 @default.
• W2914867711 cites W2625182642 @default.
• W2914867711 cites W2670389637 @default.
• W2914867711 cites W2738422158 @default.
• W2914867711 cites W2753817255 @default.
• W2914867711 cites W2758536266 @default.
• W2914867711 cites W2758750229 @default.
• W2914867711 cites W2765535683 @default.
• W2914867711 cites W2773808722 @default.
• W2914867711 cites W2780190620 @default.
• W2914867711 cites W2790505908 @default.
• W2914867711 cites W2792874077 @default.
• W2914867711 cites W2793056937 @default.
• W2914867711 cites W2794210955 @default.
• W2914867711 cites W2794577982 @default.
• W2914867711 cites W2794681534 @default.
• W2914867711 cites W2804365796 @default.
• W2914867711 cites W2883165015 @default.
• W2914867711 cites W2889355415 @default.
• W2914867711 cites W2894381186 @default.
• W2914867711 cites W2894536653 @default.
• W2914867711 cites W2897089223 @default.
• W2914867711 cites W2909080269 @default.
• W2914867711 cites W34790407 @default.
• W2914867711 cites W381922013 @default.
• W2914867711 doi "https://doi.org/10.1039/c9tx00007k" @default.
• W2914867711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6430097" @default.
• W2914867711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30997028" @default.
• W2914867711 hasPublicationYear "2019" @default.
• W2914867711 type Work @default.
• W2914867711 sameAs 2914867711 @default.
• W2914867711 citedByCount "4" @default.
• W2914867711 countsByYear W29148677112020 @default.
• W2914867711 countsByYear W29148677112022 @default.
• W2914867711 countsByYear W29148677112023 @default.
• W2914867711 crossrefType "journal-article" @default.
• W2914867711 hasAuthorship W2914867711A5017106775 @default.
• W2914867711 hasAuthorship W2914867711A5017624327 @default.
• W2914867711 hasAuthorship W2914867711A5047769327 @default.
• W2914867711 hasAuthorship W2914867711A5087741085 @default.
• W2914867711 hasBestOaLocation W29148677111 @default.
• W2914867711 hasConcept C126322002 @default.
• W2914867711 hasConcept C136229726 @default.

• next