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- W2914872022 abstract "The pivotal and diverse roles G protein-coupled receptors (GPCRs) play in physiology are matched by the increasingly complex signal systems they activate. Over the past decade, our models of GPCR signaling systems also include a vital role of location in controlling GPCR signaling, whereby plasma membrane, clathrin-associated structures and a diverse endomembrane network provide highly specialized signal platforms for this superfamily of receptors. The aim of this review is to highlight the recent developments in this fast-evolving field, with particular emphasis on endocrine-relevant GPCRs. We will also highlight studies that address the possibility of therapeutic intervention and how this fundamental cell biology can be translated to physiology/pathophysiology and therapeutic interventions." @default.
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- W2914872022 date "2019-04-01" @default.
- W2914872022 modified "2023-10-14" @default.
- W2914872022 title "Hardwiring wire-less networks: spatially encoded GPCR signaling in endocrine systems" @default.
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- W2914872022 doi "https://doi.org/10.1016/j.ceb.2018.12.009" @default.
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