Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914884408> ?p ?o ?g. }
- W2914884408 endingPage "119" @default.
- W2914884408 startingPage "110" @default.
- W2914884408 abstract "The combination of imaging and anticancer therapy has recently emerged as a promising strategy. However, nonspecific imaging signals and distribution of anticancer drugs at normal tissues limit the specificity of the combination therapy. To overcome the challenges, we designed a system which can selectively visualize cancer tissues and initiate the subsequent action of therapeutic molecules in tumor microenvironment. Exploiting the overexpression of matrix metalloproteinase (MMP) in the tumor microenvironment, we designed a graphene oxide (GO)-based nanosheet system loaded with a pegylated MMP-cleavable imaging probe and an anticancer peptide shielded under the imaging probe. GO loaded with pegylated imaging probe derivative and anticancer buforin IIb peptide (IPGO/BF) was not fluorescent and BF hidden within pegylated surfaces did not exert anticancer activity. However, in tumor microenvironment, IPGO/BF selectively provided imaging by liberating pegylated fluorescent moiety. The cleavage of MMP-sensitive peptide triggered imaging signal and subsequent exposure of shielded BF on GO and enhanced its therapeutic function. SCC7 tumor-bearing mice treated with IPGO/BF exhibited selective fluorescence in tumor tissues, and greater imaging signal-dependent antitumor effects compared with other groups. The selective imaging-dependent sequential activation of anticancer therapy in tumor microenvironment would be a feasible strategy to reduce the nonspecific false-positive signals of tumor imaging and undesirable side effects of anticancer drugs at normal tissues." @default.
- W2914884408 created "2019-02-21" @default.
- W2914884408 creator A5014332786 @default.
- W2914884408 creator A5017590377 @default.
- W2914884408 creator A5034418015 @default.
- W2914884408 creator A5039829241 @default.
- W2914884408 creator A5041182519 @default.
- W2914884408 creator A5062513648 @default.
- W2914884408 creator A5067843398 @default.
- W2914884408 creator A5070111980 @default.
- W2914884408 creator A5082577308 @default.
- W2914884408 date "2019-03-01" @default.
- W2914884408 modified "2023-09-24" @default.
- W2914884408 title "Sequential activation of anticancer therapy triggered by tumor microenvironment-selective imaging" @default.
- W2914884408 cites W1831718697 @default.
- W2914884408 cites W1935517563 @default.
- W2914884408 cites W1937753295 @default.
- W2914884408 cites W1979510766 @default.
- W2914884408 cites W1980255601 @default.
- W2914884408 cites W1987288075 @default.
- W2914884408 cites W1995384957 @default.
- W2914884408 cites W2021906259 @default.
- W2914884408 cites W2029973730 @default.
- W2914884408 cites W2042778784 @default.
- W2914884408 cites W2043991456 @default.
- W2914884408 cites W2045781042 @default.
- W2914884408 cites W2101353026 @default.
- W2914884408 cites W2104548557 @default.
- W2914884408 cites W2127426422 @default.
- W2914884408 cites W2163640116 @default.
- W2914884408 cites W2177205490 @default.
- W2914884408 cites W2194108912 @default.
- W2914884408 cites W2284550715 @default.
- W2914884408 cites W2342125717 @default.
- W2914884408 cites W2406828489 @default.
- W2914884408 cites W2517354454 @default.
- W2914884408 cites W2553579136 @default.
- W2914884408 cites W2593463573 @default.
- W2914884408 cites W2640326035 @default.
- W2914884408 cites W2794317857 @default.
- W2914884408 cites W2903598718 @default.
- W2914884408 cites W322250421 @default.
- W2914884408 cites W336402162 @default.
- W2914884408 doi "https://doi.org/10.1016/j.jconrel.2019.02.012" @default.
- W2914884408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30771413" @default.
- W2914884408 hasPublicationYear "2019" @default.
- W2914884408 type Work @default.
- W2914884408 sameAs 2914884408 @default.
- W2914884408 citedByCount "14" @default.
- W2914884408 countsByYear W29148844082019 @default.
- W2914884408 countsByYear W29148844082020 @default.
- W2914884408 countsByYear W29148844082021 @default.
- W2914884408 countsByYear W29148844082022 @default.
- W2914884408 countsByYear W29148844082023 @default.
- W2914884408 crossrefType "journal-article" @default.
- W2914884408 hasAuthorship W2914884408A5014332786 @default.
- W2914884408 hasAuthorship W2914884408A5017590377 @default.
- W2914884408 hasAuthorship W2914884408A5034418015 @default.
- W2914884408 hasAuthorship W2914884408A5039829241 @default.
- W2914884408 hasAuthorship W2914884408A5041182519 @default.
- W2914884408 hasAuthorship W2914884408A5062513648 @default.
- W2914884408 hasAuthorship W2914884408A5067843398 @default.
- W2914884408 hasAuthorship W2914884408A5070111980 @default.
- W2914884408 hasAuthorship W2914884408A5082577308 @default.
- W2914884408 hasConcept C121332964 @default.
- W2914884408 hasConcept C136339569 @default.
- W2914884408 hasConcept C150903083 @default.
- W2914884408 hasConcept C185592680 @default.
- W2914884408 hasConcept C207001950 @default.
- W2914884408 hasConcept C2776107976 @default.
- W2914884408 hasConcept C3020616263 @default.
- W2914884408 hasConcept C502942594 @default.
- W2914884408 hasConcept C57477423 @default.
- W2914884408 hasConcept C62520636 @default.
- W2914884408 hasConcept C71924100 @default.
- W2914884408 hasConcept C86803240 @default.
- W2914884408 hasConcept C91881484 @default.
- W2914884408 hasConceptScore W2914884408C121332964 @default.
- W2914884408 hasConceptScore W2914884408C136339569 @default.
- W2914884408 hasConceptScore W2914884408C150903083 @default.
- W2914884408 hasConceptScore W2914884408C185592680 @default.
- W2914884408 hasConceptScore W2914884408C207001950 @default.
- W2914884408 hasConceptScore W2914884408C2776107976 @default.
- W2914884408 hasConceptScore W2914884408C3020616263 @default.
- W2914884408 hasConceptScore W2914884408C502942594 @default.
- W2914884408 hasConceptScore W2914884408C57477423 @default.
- W2914884408 hasConceptScore W2914884408C62520636 @default.
- W2914884408 hasConceptScore W2914884408C71924100 @default.
- W2914884408 hasConceptScore W2914884408C86803240 @default.
- W2914884408 hasConceptScore W2914884408C91881484 @default.
- W2914884408 hasLocation W29148844081 @default.
- W2914884408 hasLocation W29148844082 @default.
- W2914884408 hasOpenAccess W2914884408 @default.
- W2914884408 hasPrimaryLocation W29148844081 @default.
- W2914884408 hasRelatedWork W128396028 @default.
- W2914884408 hasRelatedWork W2149597677 @default.
- W2914884408 hasRelatedWork W2487348170 @default.
- W2914884408 hasRelatedWork W2914884408 @default.