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- W2914892774 abstract "Low dose oral immunotherapy (OIT), which maintenance doses are lower than threshold doses diagnosed by oral food challenges (OFCs), is not evaluated the safety and efficacy. This was a retrospective case series study, evaluating patients who 1) tested positive on open OFCs with <10 g or ml of boiled egg white or milk from June 2016 to March 2017; 2) consumed the causative foods for one year as OIT, initiated at 1/100–1/10 and maintained at 1/10–2/3 of the total OFC doses; and 3) underwent OFCs after one year. We evaluated adverse events during low dose OIT and changes in tolerated OFC doses from initiation to 1 year. Seventeen patients aged 1–9 years (10, egg; 7, milk; with duplication) were analyzed. Regarding adverse events, symptoms involving the oral cavity occurred with 11/17 cases, and systemic symptoms occurred 0.7 times/cases/year. Median (interquartile range; IQR) total tolerated OFC doses increased from 0.3 (0.3–1.0) to 3.0 g or ml (1.0–3.0) (p=0.002). Median (IQR) ovomucoid-sIgE and milk-sIgE tended to decrease from 48.0 (33.8–64.2) to 29.1 UA/mL (17.0-39.4) (p=0.20), 69.7 (48.6–100.0) to 24.2 UA/mL (17.8–100.0) (p=0.36), respectively. Adverse events occurred 0.7 times/cases/year. It might be necessary to implement lower doses in our protocol." @default.
- W2914892774 created "2019-02-21" @default.
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- W2914892774 date "2019-02-01" @default.
- W2914892774 modified "2023-09-27" @default.
- W2914892774 title "Low Dose Oral Immunotherapy In Children With Egg and Milk Allergies: A Retrospective Case Series Study" @default.
- W2914892774 doi "https://doi.org/10.1016/j.jaci.2018.12.839" @default.
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