Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914893853> ?p ?o ?g. }
- W2914893853 endingPage "143" @default.
- W2914893853 startingPage "131" @default.
- W2914893853 abstract "Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial and highly prevalent endocrine disorder, progress towards a cure is hindered by absence of a definitive pathogenic mechanism and lack of an animal model of naturally occurring PCOS.These include an overview of PCOS and its potential etiology, and an examination of insights gained into its pathogenic origins. Animal models derived from experimentally-induced hyperandrogenism during gestation, or from naturally-occurring PCOS-like traits, most reliably demonstrate reproductive, neuroendocrine and metabolic pathogenesis.Genetic studies, while identifying at least 17 PCOS risk genes, account for <10% of women with PCOS. A number of PCOS risk genes involve regulation of gonadotropin secretion or action, suggesting a reproductive neuroendocrine basis for PCOS pathogenesis. Consistent with this notion, a number of animal models employing fetal androgen excess demonstrate epigenetic induction of PCOS-like traits, including reproductive neuroendocrine and metabolic dysfunction. Monkey models are most comprehensive, while mouse models provide molecular insight, including identifying the androgen receptor, particularly in neurons, as mediating androgen-induced PCOS-like programming. Naturally-occurring female hyperandrogenism is also demonstrated in monkeys. Animal models are poised to delineate molecular gateways to PCOS pathogenesis." @default.
- W2914893853 created "2019-02-21" @default.
- W2914893853 creator A5014769599 @default.
- W2914893853 creator A5076631853 @default.
- W2914893853 creator A5083253733 @default.
- W2914893853 date "2019-02-15" @default.
- W2914893853 modified "2023-10-16" @default.
- W2914893853 title "Hyperandrogenic origins of polycystic ovary syndrome – implications for pathophysiology and therapy" @default.
- W2914893853 cites W111764737 @default.
- W2914893853 cites W1128977061 @default.
- W2914893853 cites W1582948480 @default.
- W2914893853 cites W1648886063 @default.
- W2914893853 cites W1755596772 @default.
- W2914893853 cites W1923981005 @default.
- W2914893853 cites W1962006036 @default.
- W2914893853 cites W1964881603 @default.
- W2914893853 cites W1967263394 @default.
- W2914893853 cites W1967564560 @default.
- W2914893853 cites W1972008706 @default.
- W2914893853 cites W1973682539 @default.
- W2914893853 cites W1977370592 @default.
- W2914893853 cites W1982440752 @default.
- W2914893853 cites W1984125311 @default.
- W2914893853 cites W1984721823 @default.
- W2914893853 cites W1988370093 @default.
- W2914893853 cites W1989557894 @default.
- W2914893853 cites W1989797259 @default.
- W2914893853 cites W1992415333 @default.
- W2914893853 cites W1998299798 @default.
- W2914893853 cites W1999649031 @default.
- W2914893853 cites W2004680590 @default.
- W2914893853 cites W2008951729 @default.
- W2914893853 cites W2016587830 @default.
- W2914893853 cites W2019771529 @default.
- W2914893853 cites W2021791932 @default.
- W2914893853 cites W2025718244 @default.
- W2914893853 cites W2026599443 @default.
- W2914893853 cites W2026854030 @default.
- W2914893853 cites W2030462220 @default.
- W2914893853 cites W2031729354 @default.
- W2914893853 cites W2032055419 @default.
- W2914893853 cites W2032313252 @default.
- W2914893853 cites W2033484016 @default.
- W2914893853 cites W2039410885 @default.
- W2914893853 cites W2042344949 @default.
- W2914893853 cites W2045550495 @default.
- W2914893853 cites W2045679033 @default.
- W2914893853 cites W2050807296 @default.
- W2914893853 cites W2052785258 @default.
- W2914893853 cites W2053105417 @default.
- W2914893853 cites W2054277684 @default.
- W2914893853 cites W2055206546 @default.
- W2914893853 cites W2056198326 @default.
- W2914893853 cites W2056553615 @default.
- W2914893853 cites W2058667120 @default.
- W2914893853 cites W2062389660 @default.
- W2914893853 cites W2062951759 @default.
- W2914893853 cites W2063008992 @default.
- W2914893853 cites W2064001826 @default.
- W2914893853 cites W2065788149 @default.
- W2914893853 cites W2068224022 @default.
- W2914893853 cites W2071134750 @default.
- W2914893853 cites W2071542414 @default.
- W2914893853 cites W2072345165 @default.
- W2914893853 cites W2081095883 @default.
- W2914893853 cites W2086760234 @default.
- W2914893853 cites W2087380222 @default.
- W2914893853 cites W2088211310 @default.
- W2914893853 cites W2091182727 @default.
- W2914893853 cites W2096347467 @default.
- W2914893853 cites W2099511866 @default.
- W2914893853 cites W2100359846 @default.
- W2914893853 cites W2101119214 @default.
- W2914893853 cites W2103732683 @default.
- W2914893853 cites W2104549611 @default.
- W2914893853 cites W2105749473 @default.
- W2914893853 cites W2107051827 @default.
- W2914893853 cites W2113015511 @default.
- W2914893853 cites W2113329249 @default.
- W2914893853 cites W2114688343 @default.
- W2914893853 cites W2116617338 @default.
- W2914893853 cites W2118575626 @default.
- W2914893853 cites W2118848273 @default.
- W2914893853 cites W2122719731 @default.
- W2914893853 cites W2123009569 @default.
- W2914893853 cites W2123316903 @default.
- W2914893853 cites W2123937315 @default.
- W2914893853 cites W2124074195 @default.
- W2914893853 cites W2125529814 @default.
- W2914893853 cites W2126781372 @default.
- W2914893853 cites W2128242453 @default.
- W2914893853 cites W2128582539 @default.
- W2914893853 cites W2130006622 @default.
- W2914893853 cites W2132339919 @default.
- W2914893853 cites W2133981510 @default.
- W2914893853 cites W2135705669 @default.
- W2914893853 cites W2137214862 @default.
- W2914893853 cites W2139915659 @default.