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• W2914897371 abstract "Significance Amino acid copolymers that are used in the treatment of experimental autoimmune encephalomyelitis (EAE) in mice or multiple sclerosis (MS) in humans result in the induction of immunosuppressive IL-10–secreting regulatory T cells. The TCRs of these T cells have previously been isolated and sequenced. Introduction of these TCR into a retroviral vector was used to transduce murine hematopoietic stem/progenitor cells (HSC/HPC). These genetically modified HSC/HPC were then transplanted to create retrogenic mice. Splenocytes or T cells of these retrogenic mice produced high levels of IL-10 on appropriate stimulation, and strongly suggests that the TCR itself encodes information for IL-10 secretion. Moreover, these retrogenic mice were resistant to induction of EAE, suggesting an approach to therapy for progressive MS using genetically modified HSC/HPC for transplantation." @default.
• W2914897371 created "2019-02-21" @default.
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• W2914897371 date "2019-01-25" @default.
• W2914897371 modified "2023-09-27" @default.
• W2914897371 title "Genetically modified hematopoietic stem/progenitor cells that produce IL-10–secreting regulatory T cells" @default.
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• W2914897371 doi "https://doi.org/10.1073/pnas.1811984116" @default.
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