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- W2914904782 abstract "Maintenance of Ca 2+ homeostasis is important for fungal cells to respond to a multitude of stresses, as well as antifungal treatment, and for virulence in animal models. Here, we demonstrate that a P-type ATPase, Pmc1p, is required for Candida albicans to respond to a variety of stresses, affects azole susceptibility, and is required to sustain tissue invasive hyphal growth and to cause disease in a mouse model of disseminated infection. Defining the mechanisms responsible for maintaining proper Ca 2+ homeostasis in this important human pathogen can ultimately provide opportunities to devise new chemotherapeutic interventions that dysregulate intracellular signaling and induce Ca 2+ toxicity." @default.
- W2914904782 created "2019-02-21" @default.
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- W2914904782 date "2019-02-27" @default.
- W2914904782 modified "2023-09-23" @default.
- W2914904782 title "The Vacuolar Ca <sup>2+</sup> ATPase Pump Pmc1p Is Required for Candida albicans Pathogenesis" @default.
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- W2914904782 doi "https://doi.org/10.1128/msphere.00715-18" @default.
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