FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914906640> ?p ?o ?g. }

• W2914906640 endingPage "2630" @default.
• W2914906640 startingPage "2618" @default.
• W2914906640 abstract "We previously reported the serendipitous observation that fenbendazole, a benzimidazole anthelmintic, improved functional and pathological outcomes following thoracic spinal cord contusion injury in mice when administered pre-injury. Fenbendazole is widely used in veterinary medicine. However, it is not approved for human use and it was uncertain if only post-injury administration would offer similar benefits. In the present study we evaluated post-injury administration of a closely related, human anthelmintic drug, flubendazole, using a rat spinal cord contusion injury model. Flubendazole, administered i.p. 5 or 10 mg/kg day, beginning 3 h post-injury and daily thereafter for 2 or 4 weeks, resulted in improved locomotor function after contusion spinal cord injury (SCI) compared with vehicle-treated controls. Histological analysis of spinal cord sections showed that such treatment with flubendazole also reduced lesion volume and improved total tissue sparing, white matter sparing, and gray matter sparing. Flubendazole inhibited the activation of glial fibrillary acidic protein (GFAP); suppressed cyclin B1 expression and Bruton tyrosine kinase activation, markers of B cell activation/proliferation and inflammation; and reduced B cell autoimmune response. Together, these results suggest the use of the benzimidazole anthelmintic flubendazole as a potential therapeutic for SCI." @default.
• W2914906640 created "2019-02-21" @default.
• W2914906640 creator A5003994463 @default.
• W2914906640 creator A5006129463 @default.
• W2914906640 creator A5014043601 @default.
• W2914906640 creator A5023248460 @default.
• W2914906640 creator A5036260496 @default.
• W2914906640 creator A5036840008 @default.
• W2914906640 creator A5042794359 @default.
• W2914906640 creator A5046026012 @default.
• W2914906640 creator A5071523608 @default.
• W2914906640 creator A5071650582 @default.
• W2914906640 creator A5073393035 @default.
• W2914906640 date "2019-09-15" @default.
• W2914906640 modified "2023-10-16" @default.
• W2914906640 title "Repositioning Flubendazole for Spinal Cord Injury" @default.
• W2914906640 cites W1153335416 @default.
• W2914906640 cites W12270064 @default.
• W2914906640 cites W1569061064 @default.
• W2914906640 cites W1654551777 @default.
• W2914906640 cites W1738826400 @default.
• W2914906640 cites W1965021269 @default.
• W2914906640 cites W1966408152 @default.
• W2914906640 cites W1971579914 @default.
• W2914906640 cites W1972956052 @default.
• W2914906640 cites W1975724680 @default.
• W2914906640 cites W1984082512 @default.
• W2914906640 cites W1984580850 @default.
• W2914906640 cites W1985284098 @default.
• W2914906640 cites W1990406538 @default.
• W2914906640 cites W1999730565 @default.
• W2914906640 cites W2003219556 @default.
• W2914906640 cites W2003632211 @default.
• W2914906640 cites W2006713454 @default.
• W2914906640 cites W2014923125 @default.
• W2914906640 cites W2022502294 @default.
• W2914906640 cites W2025797605 @default.
• W2914906640 cites W2027238676 @default.
• W2914906640 cites W2039758887 @default.
• W2914906640 cites W2043086552 @default.
• W2914906640 cites W2049034253 @default.
• W2914906640 cites W2058116209 @default.
• W2914906640 cites W2058424528 @default.
• W2914906640 cites W2063066637 @default.
• W2914906640 cites W2065010528 @default.
• W2914906640 cites W2069439128 @default.
• W2914906640 cites W2074347542 @default.
• W2914906640 cites W2082562172 @default.
• W2914906640 cites W2089771332 @default.
• W2914906640 cites W2092126110 @default.
• W2914906640 cites W2093276324 @default.
• W2914906640 cites W2098403759 @default.
• W2914906640 cites W2112844656 @default.
• W2914906640 cites W2120636793 @default.
• W2914906640 cites W2120863112 @default.
• W2914906640 cites W2121584507 @default.
• W2914906640 cites W2128383347 @default.
• W2914906640 cites W2147311935 @default.
• W2914906640 cites W2148945613 @default.
• W2914906640 cites W2153591826 @default.
• W2914906640 cites W2160367702 @default.
• W2914906640 cites W2162283328 @default.
• W2914906640 cites W2168655254 @default.
• W2914906640 cites W2172081252 @default.
• W2914906640 cites W2172644304 @default.
• W2914906640 cites W2222083162 @default.
• W2914906640 cites W2256648825 @default.
• W2914906640 cites W2290466312 @default.
• W2914906640 cites W2320744367 @default.
• W2914906640 cites W2400356771 @default.
• W2914906640 cites W2402773267 @default.
• W2914906640 cites W2435000139 @default.
• W2914906640 cites W2567263507 @default.
• W2914906640 cites W2567458296 @default.
• W2914906640 cites W2602491947 @default.
• W2914906640 cites W2617189616 @default.
• W2914906640 cites W2805588714 @default.
• W2914906640 cites W2886658966 @default.
• W2914906640 cites W2903045968 @default.
• W2914906640 cites W4242171500 @default.
• W2914906640 cites W2116099242 @default.
• W2914906640 doi "https://doi.org/10.1089/neu.2018.6160" @default.
• W2914906640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6727476" @default.
• W2914906640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30747048" @default.
• W2914906640 hasPublicationYear "2019" @default.
• W2914906640 type Work @default.
• W2914906640 sameAs 2914906640 @default.
• W2914906640 citedByCount "5" @default.
• W2914906640 countsByYear W29149066402021 @default.
• W2914906640 countsByYear W29149066402022 @default.
• W2914906640 countsByYear W29149066402023 @default.
• W2914906640 crossrefType "journal-article" @default.
• W2914906640 hasAuthorship W2914906640A5003994463 @default.
• W2914906640 hasAuthorship W2914906640A5006129463 @default.
• W2914906640 hasAuthorship W2914906640A5014043601 @default.
• W2914906640 hasAuthorship W2914906640A5023248460 @default.
• W2914906640 hasAuthorship W2914906640A5036260496 @default.
• W2914906640 hasAuthorship W2914906640A5036840008 @default.

• next