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- W2914910178 abstract "Protective effects of Digera muricata (DM) methanol extract (DME) were evaluated against the oxidative stress of carbon tetrachloride (CCl 4 ) in the thyroid of male Sprague-Dawley rats. Treatment of CCl 4 1 ml/kg bw (25% CCl 4 /olive oil i.p) once a week for 16 weeks significantly decreased the activities of catalase, peroxidase, superoxide dismutase, glutathione-S-transferase and glutathione peroxidase in the thyroid. Level of reduced glutathione was decreased, while lipid peroxidation (TBARS) was significantly increased with CCl 4 in the thyroid of rat. CCl 4 significantly enhanced the level of thyroidal DNA injuries and AgNORs count. Serum level of TT 3 and TT 4 was significantly decreased, while TSH level was increased with CCl 4 treatment. Pleiomorphic histopathological abnormalities in thyroid were caused by CCl 4 treatment. Co-treatment of DME (100 and 200 mg/kg bw) intragastrically once a week for 16 weeks suppressed the toxic effects of CCl 4 and level of thyroid hormones, the activities of oxidative enzymes, glutathione (GSH) and TBARS concentration. Histopathological injuries induced with CCl 4 were remarkably reduced with co-treatment of DME in a dose dependent fashion. These results suggest that the ameliorative effects of DME could be attributed to radical scavenging or antioxidant properties. Key words : Thyroid hormone, carbon tetrachloride, peroxidase, lipid peroxidation (TBARS), Digera muricata, argyrophilic nucleolar organizer region" @default.
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- W2914910178 date "2011-11-30" @default.
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- W2914910178 title "Protective effects of Digera muricata (L.) Mart. against carbon tetrachloride induced oxidative stress in thyroid of rat" @default.
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- W2914910178 doi "https://doi.org/10.5897/ajb11.691" @default.
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