Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914921421> ?p ?o ?g. }
- W2914921421 abstract "Persistent infection with HCMV is associated with the operation of diverse evasion phenotypes directed at antiviral immunity. Obstruction of intrinsic and innate immune responses is typically conferred by viral proteins either associated with the viral particle or expressed immediately after entry. In line with this, numerous phenotypes are attributed to the HCMV IE86 protein that involve interference with innate immune processes via transcriptional and protein-directed mechanisms. We describe novel IE86-mediated phenotypes aimed at virus-induced secretion of IL-1β. Intriguingly, while many viruses target the function of the molecular scaffold required for IL-1β maturation to prevent this response, we find that HCMV and IE86 target the IL-1β protein specifically. Moreover, we show that IE86 impairs both the synthesis of the IL-1β transcript and the stability of the immature protein. This indicates an unusual phenomenon in which a single viral protein exhibits two molecularly separate evasion phenotypes directed at a single innate cytokine." @default.
- W2914921421 created "2019-02-21" @default.
- W2914921421 creator A5012696027 @default.
- W2914921421 creator A5021779336 @default.
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- W2914921421 creator A5027515964 @default.
- W2914921421 creator A5045962739 @default.
- W2914921421 creator A5057789931 @default.
- W2914921421 creator A5061712356 @default.
- W2914921421 creator A5083850882 @default.
- W2914921421 creator A5088305681 @default.
- W2914921421 date "2019-02-26" @default.
- W2914921421 modified "2023-10-14" @default.
- W2914921421 title "Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome" @default.
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