FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914929286> ?p ?o ?g. }

• W2914929286 endingPage "1312" @default.
• W2914929286 startingPage "1293" @default.
• W2914929286 abstract "Recent advances in proteomics present enormous opportunities to discover proteome related disparities and thus understanding the molecular mechanisms related to a disease. Uterine leiomyoma is a benign monoclonal tumor, located in the pelvic region, and affecting 40% of reproductive aged female.Identification and characterization of the differentially expressed proteins associated with leiomyogenesis by comparing uterine leiomyoma and normal myometrium.Paired samples of uterine leiomyoma and adjacent myometrium retrieved from twenty-five females suffering from uterine leiomyoma (n=50) were submitted to two-dimensional electrophoresis (2-DE), matrixassisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and to reverse transcription polymerase chain reaction (RT-PCR).Comparison of protein patterns revealed seven proteins with concordantly increased spot intensities in leiomyoma samples. E3 ubiquitin-protein ligase MIB2 (MIB2), Mediator of RNA polymerase II transcription subunit 10 (MED10), HIRA-interacting protein (HIRP3) and Fatty acid binding protein brain (FABP7) were found to be upregulated. While, Biogenesis of lysosome-related organelles complex 1 subunit 2 (BL1S2), Shadow of prion protein (SPRN) and RNA binding motif protein X linked like 2 (RMXL2) were found to be exclusively present in leiomyoma sample. The expression modulations of the corresponding genes were further validated which corroborated with the 2-DE result showing significant upregulation in leiomyoma. We have generated a master network showing the interactions of the experimentally identified proteins with their close neighbors and further scrutinized the network to prioritize the routes leading to cell proliferation and tumorigenesis.This study highlights the importance of identified proteins as potential targets for therapeutic purpose. This work provides an insight into the mechanism underlying the overexpression of the proteins but warrants further investigations." @default.
• W2914929286 created "2019-02-21" @default.
• W2914929286 creator A5003747713 @default.
• W2914929286 creator A5010143844 @default.
• W2914929286 creator A5011268440 @default.
• W2914929286 creator A5033389629 @default.
• W2914929286 creator A5063629453 @default.
• W2914929286 creator A5068664624 @default.
• W2914929286 creator A5075620318 @default.
• W2914929286 date "2019-10-24" @default.
• W2914929286 modified "2023-10-18" @default.
• W2914929286 title "Interactome Analysis of the Differentially Expressed Proteins in Uterine Leiomyoma" @default.
• W2914929286 cites W123005099 @default.
• W2914929286 cites W1512720088 @default.
• W2914929286 cites W1582888021 @default.
• W2914929286 cites W1905640125 @default.
• W2914929286 cites W1957958353 @default.
• W2914929286 cites W1980573720 @default.
• W2914929286 cites W1985753916 @default.
• W2914929286 cites W1986926802 @default.
• W2914929286 cites W1987927648 @default.
• W2914929286 cites W1989588875 @default.
• W2914929286 cites W1996287189 @default.
• W2914929286 cites W1996476188 @default.
• W2914929286 cites W2005000963 @default.
• W2914929286 cites W2005727122 @default.
• W2914929286 cites W2009742890 @default.
• W2914929286 cites W2015034754 @default.
• W2914929286 cites W2041072118 @default.
• W2914929286 cites W2044681630 @default.
• W2914929286 cites W2051871861 @default.
• W2914929286 cites W2056979920 @default.
• W2914929286 cites W2058600996 @default.
• W2914929286 cites W2060459047 @default.
• W2914929286 cites W2061347817 @default.
• W2914929286 cites W2066910371 @default.
• W2914929286 cites W2068036822 @default.
• W2914929286 cites W2069152026 @default.
• W2914929286 cites W2072954540 @default.
• W2914929286 cites W2081263721 @default.
• W2914929286 cites W2086630637 @default.
• W2914929286 cites W2087255669 @default.
• W2914929286 cites W2100837269 @default.
• W2914929286 cites W2101622006 @default.
• W2914929286 cites W2102814473 @default.
• W2914929286 cites W2113247978 @default.
• W2914929286 cites W2114451103 @default.
• W2914929286 cites W2117641141 @default.
• W2914929286 cites W2120777670 @default.
• W2914929286 cites W2120807407 @default.
• W2914929286 cites W2128416360 @default.
• W2914929286 cites W2132519593 @default.
• W2914929286 cites W2134685322 @default.
• W2914929286 cites W2137469924 @default.
• W2914929286 cites W2150163498 @default.
• W2914929286 cites W2158402820 @default.
• W2914929286 cites W2159157279 @default.
• W2914929286 cites W2167584983 @default.
• W2914929286 cites W2318313220 @default.
• W2914929286 cites W2403998678 @default.
• W2914929286 cites W2406549084 @default.
• W2914929286 cites W2484658895 @default.
• W2914929286 cites W2525992712 @default.
• W2914929286 cites W2558631900 @default.
• W2914929286 cites W2563423381 @default.
• W2914929286 cites W2614388893 @default.
• W2914929286 cites W2767062467 @default.
• W2914929286 cites W2770132733 @default.
• W2914929286 cites W2903483444 @default.
• W2914929286 cites W3151303851 @default.
• W2914929286 cites W3172066546 @default.
• W2914929286 cites W4293247451 @default.
• W2914929286 cites W4379462908 @default.
• W2914929286 doi "https://doi.org/10.2174/1871520619666190206143523" @default.
• W2914929286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30727917" @default.
• W2914929286 hasPublicationYear "2019" @default.
• W2914929286 type Work @default.
• W2914929286 sameAs 2914929286 @default.
• W2914929286 citedByCount "6" @default.
• W2914929286 countsByYear W29149292862020 @default.
• W2914929286 countsByYear W29149292862021 @default.
• W2914929286 countsByYear W29149292862022 @default.
• W2914929286 countsByYear W29149292862023 @default.
• W2914929286 crossrefType "journal-article" @default.
• W2914929286 hasAuthorship W2914929286A5003747713 @default.
• W2914929286 hasAuthorship W2914929286A5010143844 @default.
• W2914929286 hasAuthorship W2914929286A5011268440 @default.
• W2914929286 hasAuthorship W2914929286A5033389629 @default.
• W2914929286 hasAuthorship W2914929286A5063629453 @default.
• W2914929286 hasAuthorship W2914929286A5068664624 @default.
• W2914929286 hasAuthorship W2914929286A5075620318 @default.
• W2914929286 hasConcept C104292427 @default.
• W2914929286 hasConcept C104317684 @default.
• W2914929286 hasConcept C104397665 @default.
• W2914929286 hasConcept C142724271 @default.
• W2914929286 hasConcept C153911025 @default.
• W2914929286 hasConcept C2777795800 @default.
• W2914929286 hasConcept C2778164554 @default.

• next