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- W2914931437 abstract "Immunohistochemical (IHC) staining for CK5/6 and CK20 was reported to be correlated with the prognosis of early urothelial carcinoma in a way contrary to that of advanced tumors for unknown reasons. We aimed to characterize the gene expression profiles of subgroups of non-muscle-invasive papillary high-grade upper tract urothelial carcinoma (UTUC) classified by CK5/6 and CK20 expression levels: group 1 (CK5/6-high/CK20-low), group 2 (CK5/6-high/CK20-high), and group 3 (CK5/6-low/CK20-high). Expression of group 3 was predictive of worse prognosis of non-muscle-invasive papillary high-grade UTUC. Transcriptional analysis revealed 308 differentially expressed genes across the subgroups. Functional analyses of the genes identified cell adhesion as a common process differentially enriched in group 3 compared to the other groups, which could explain its high-risk phenotype. Late cell cycle/proliferation signatures were also enriched in group 3 and in some of the other groups, which may be used as a prognostic biomarker complementary to CK5/6 and CK20. Group 2, characterized by low levels of genes associated with mitogen-activated protein kinase and tumor necrosis factor signaling pathways, was hypothesized to represent the least cancerous subtype considering its normal urothelium-like IHC pattern. This study would facilitate the application of easily accessible prognostic biomarkers in practice." @default.
- W2914931437 created "2019-02-21" @default.
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- W2914931437 date "2019-01-29" @default.
- W2914931437 modified "2023-10-17" @default.
- W2914931437 title "Transcriptional Analysis of Immunohistochemically Defined Subgroups of Non-Muscle-Invasive Papillary High-Grade Upper Tract Urothelial Carcinoma" @default.
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- W2914931437 doi "https://doi.org/10.3390/ijms20030570" @default.
- W2914931437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6386996" @default.
- W2914931437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30699951" @default.
- W2914931437 hasPublicationYear "2019" @default.
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