Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914932395> ?p ?o ?g. }
- W2914932395 endingPage "3738" @default.
- W2914932395 startingPage "3728" @default.
- W2914932395 abstract "Members of the pentatricopeptide repeat (PPR) protein family are sequence-specific RNA-binding proteins that play crucial roles in organelle RNA metabolism. Each PPR protein consists of a tandem array of PPR motifs, each of which aligns to one nucleotide of the RNA target. The di-residues in the PPR motif, which are referred to as the PPR codes, determine nucleotide specificity. Numerous PPR codes are distributed among the vast number of PPR motifs, but the correlation between PPR codes and RNA bases is poorly understood, which hinders target RNA prediction and functional investigation of PPR proteins. To address this issue, we developed a modular assembly method for high-throughput construction of designer PPRs, and by using this method, 62 designer PPR proteins containing various PPR codes were assembled. Then, the correlation between these PPR codes and RNA bases was systematically explored and delineated. Based on this correlation, the web server PPRCODE (http://yinlab.hzau.edu.cn/pprcode) was developed. Our study will not only serve as a platform for facilitating target RNA prediction and functional investigation of the large number of PPR family proteins but also provide an alternative strategy for the assembly of custom PPRs that can potentially be used for plant organelle RNA manipulation." @default.
- W2914932395 created "2019-02-21" @default.
- W2914932395 creator A5006173938 @default.
- W2914932395 creator A5008607594 @default.
- W2914932395 creator A5010567621 @default.
- W2914932395 creator A5012403428 @default.
- W2914932395 creator A5019431327 @default.
- W2914932395 creator A5041423906 @default.
- W2914932395 creator A5041638041 @default.
- W2914932395 creator A5057077440 @default.
- W2914932395 creator A5059306322 @default.
- W2914932395 date "2019-02-11" @default.
- W2914932395 modified "2023-10-16" @default.
- W2914932395 title "Delineation of pentatricopeptide repeat codes for target RNA prediction" @default.
- W2914932395 cites W1482287389 @default.
- W2914932395 cites W1580865324 @default.
- W2914932395 cites W1685412793 @default.
- W2914932395 cites W1810415345 @default.
- W2914932395 cites W1983106131 @default.
- W2914932395 cites W2002679195 @default.
- W2914932395 cites W2011476464 @default.
- W2914932395 cites W2027569006 @default.
- W2914932395 cites W2035356606 @default.
- W2914932395 cites W2042792861 @default.
- W2914932395 cites W2047949222 @default.
- W2914932395 cites W2065921473 @default.
- W2914932395 cites W2067049315 @default.
- W2914932395 cites W2079755769 @default.
- W2914932395 cites W2096312357 @default.
- W2914932395 cites W2096634604 @default.
- W2914932395 cites W2113729177 @default.
- W2914932395 cites W2122369649 @default.
- W2914932395 cites W2122870633 @default.
- W2914932395 cites W2123502134 @default.
- W2914932395 cites W2123868493 @default.
- W2914932395 cites W2125079066 @default.
- W2914932395 cites W2126465929 @default.
- W2914932395 cites W2139044529 @default.
- W2914932395 cites W2141685791 @default.
- W2914932395 cites W2154786191 @default.
- W2914932395 cites W2158892309 @default.
- W2914932395 cites W2163677890 @default.
- W2914932395 cites W2163801773 @default.
- W2914932395 cites W2164567989 @default.
- W2914932395 cites W2169861297 @default.
- W2914932395 cites W2177098691 @default.
- W2914932395 cites W2195532659 @default.
- W2914932395 cites W2257097671 @default.
- W2914932395 cites W2331448242 @default.
- W2914932395 cites W2337463400 @default.
- W2914932395 cites W2337834530 @default.
- W2914932395 cites W2416174964 @default.
- W2914932395 cites W2513416254 @default.
- W2914932395 cites W2564928826 @default.
- W2914932395 cites W2571952481 @default.
- W2914932395 cites W2586828486 @default.
- W2914932395 cites W2606036326 @default.
- W2914932395 cites W2738299773 @default.
- W2914932395 cites W2768093671 @default.
- W2914932395 cites W2776399449 @default.
- W2914932395 cites W2792461449 @default.
- W2914932395 cites W2894828038 @default.
- W2914932395 cites W2904479066 @default.
- W2914932395 doi "https://doi.org/10.1093/nar/gkz075" @default.
- W2914932395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6468296" @default.
- W2914932395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30753696" @default.
- W2914932395 hasPublicationYear "2019" @default.
- W2914932395 type Work @default.
- W2914932395 sameAs 2914932395 @default.
- W2914932395 citedByCount "92" @default.
- W2914932395 countsByYear W29149323952019 @default.
- W2914932395 countsByYear W29149323952020 @default.
- W2914932395 countsByYear W29149323952021 @default.
- W2914932395 countsByYear W29149323952022 @default.
- W2914932395 countsByYear W29149323952023 @default.
- W2914932395 crossrefType "journal-article" @default.
- W2914932395 hasAuthorship W2914932395A5006173938 @default.
- W2914932395 hasAuthorship W2914932395A5008607594 @default.
- W2914932395 hasAuthorship W2914932395A5010567621 @default.
- W2914932395 hasAuthorship W2914932395A5012403428 @default.
- W2914932395 hasAuthorship W2914932395A5019431327 @default.
- W2914932395 hasAuthorship W2914932395A5041423906 @default.
- W2914932395 hasAuthorship W2914932395A5041638041 @default.
- W2914932395 hasAuthorship W2914932395A5057077440 @default.
- W2914932395 hasAuthorship W2914932395A5059306322 @default.
- W2914932395 hasBestOaLocation W29149323951 @default.
- W2914932395 hasConcept C104317684 @default.
- W2914932395 hasConcept C21786251 @default.
- W2914932395 hasConcept C2775972742 @default.
- W2914932395 hasConcept C54355233 @default.
- W2914932395 hasConcept C60644358 @default.
- W2914932395 hasConcept C67705224 @default.
- W2914932395 hasConcept C70721500 @default.
- W2914932395 hasConcept C86803240 @default.
- W2914932395 hasConceptScore W2914932395C104317684 @default.
- W2914932395 hasConceptScore W2914932395C21786251 @default.
- W2914932395 hasConceptScore W2914932395C2775972742 @default.
- W2914932395 hasConceptScore W2914932395C54355233 @default.