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- W2914943094 abstract "Background: Organophosphate pesticides (OP) were commonly used in agriculture and residential settings in the last decades. Three American cohorts have recently showed associations between prenatal OP exposure and cognitive deficits in children. Aims: To investigate among 6-year old children the relationship between prenatal urinary OP levels and scores of the Wechsler Intelligence Scale for Children (WISC-IV) used in the previous cohorts. Methods: From a random subcohort of the PELAGIE cohort that included 3500 pregnant women in Brittany (France, 2002-2006), 231 children were followed at 6-year old for neuropsychological assessment. Prenatal exposure was determined by assessing OP metabolites (Dialkylphophate DAP, Diethylphosphate DE and Dimethylphosphate DM) in maternal urine samples collected during the first trimester of pregnancy. The WISC-IV was used to obtain a working memory index and a verbal comprehension index. Preliminary analyses based on multivariate regressions were conducted controlling for potential confounding factors including family stimulation from the Home Observation for Measurement of the Environment scale. Results: Mean DAP, DE and DM detected concentrations in nmol/L were 81.0 (n=211), 22.7 (n=115), 69.9 (n=207) respectively. Adjusted means of the WISC indexes did not differ between quartiles of urinary levels of DAP metabolites (from the lowest to the highest quartile ; WM : 107.04, 105.29, 105.62, 109.79; CV : 104.67, 105.73, 110.24, 107.89), nor for DE or DM metabolites. Conclusions: This study did not observe association between prenatal urinary OP levels and WISC scores in 6-year old children. Inconsistency with the previous results might be explained by lower OP levels or no ethnic minority in our study population." @default.
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- W2914943094 date "2013-09-19" @default.
- W2914943094 modified "2023-09-25" @default.
- W2914943094 title "Prenatal exposure to organophosphate insecticides and cognitive function of 6 years old children in the mother-child PELAGIE cohort (France)" @default.
- W2914943094 doi "https://doi.org/10.1289/isee.2013.p-3-23-19" @default.
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