Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914954682> ?p ?o ?g. }
- W2914954682 endingPage "743" @default.
- W2914954682 startingPage "737" @default.
- W2914954682 abstract "Nociceptive sensory nerve fibers have never been investigated in the ligamentum flavum (LF) of patients with LSS. The aim was to analyze nociceptive sensory nerve fibers in the ligamentum flavum (LF) of patients with LSS. A prospective study in patients with lumbar spinal stenosis (LSS) undergoing invasive surgical treatment for lumbar spinal stenosis (LSS) with flavectomy was performed. Patients with LSS were subjected to flavectomy and density of sensory and sympathetic nerve fibers, macrophages, vessels, activated fibroblasts, and cells were investigated by immunostaining techniques. A group of patients with acute disc herniation served as control group. We found a higher density of sensory nerve fibers in LSS patients versus controls. These findings support the role of LF in associated low back pain. Density of sensory nerve fibers in LSS, was positively correlated with typical markers of clinical pain and functional disability, but not with LF density of activated fibroblasts. Inflammation as estimated by macrophage infiltration and higher vascularity does not play a marked role in LF in our LSS patients. In the present study, compared to men with LSS, women with LSS demonstrate more pain and depression, and show a higher density of sensory nerve fibers in LF. This study shed new light on nociceptive nerve fibers, which are increased in LSS compared to controls. The findings speak against a strong inflammatory component in LSS. A higher pain levels in women compared to men can be explained by a higher density of nociceptive nerve fibers. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:1-7, 2019." @default.
- W2914954682 created "2019-02-21" @default.
- W2914954682 creator A5013726200 @default.
- W2914954682 creator A5021435173 @default.
- W2914954682 creator A5032141784 @default.
- W2914954682 creator A5040844384 @default.
- W2914954682 creator A5045563618 @default.
- W2914954682 creator A5067250316 @default.
- W2914954682 date "2019-02-28" @default.
- W2914954682 modified "2023-10-12" @default.
- W2914954682 title "Increased pain and sensory hyperinnervation of the ligamentum flavum in patients with lumbar spinal stenosis" @default.
- W2914954682 cites W1646685313 @default.
- W2914954682 cites W1836887645 @default.
- W2914954682 cites W1968549810 @default.
- W2914954682 cites W1974941555 @default.
- W2914954682 cites W1981185668 @default.
- W2914954682 cites W1985903939 @default.
- W2914954682 cites W1986878197 @default.
- W2914954682 cites W1987009915 @default.
- W2914954682 cites W1994823722 @default.
- W2914954682 cites W1996785852 @default.
- W2914954682 cites W1999072050 @default.
- W2914954682 cites W2003099895 @default.
- W2914954682 cites W2019963640 @default.
- W2914954682 cites W2026437906 @default.
- W2914954682 cites W2030259053 @default.
- W2914954682 cites W2036035048 @default.
- W2914954682 cites W2038874399 @default.
- W2914954682 cites W2038897604 @default.
- W2914954682 cites W2048040148 @default.
- W2914954682 cites W2055196022 @default.
- W2914954682 cites W2056056632 @default.
- W2914954682 cites W2058807602 @default.
- W2914954682 cites W2063663557 @default.
- W2914954682 cites W2065297763 @default.
- W2914954682 cites W2068928437 @default.
- W2914954682 cites W2071560292 @default.
- W2914954682 cites W2075715972 @default.
- W2914954682 cites W2077912387 @default.
- W2914954682 cites W2081376664 @default.
- W2914954682 cites W2087340224 @default.
- W2914954682 cites W2101285397 @default.
- W2914954682 cites W2108886402 @default.
- W2914954682 cites W2129027514 @default.
- W2914954682 cites W2132352013 @default.
- W2914954682 cites W2146182488 @default.
- W2914954682 cites W2147489823 @default.
- W2914954682 cites W2147859219 @default.
- W2914954682 cites W2154798479 @default.
- W2914954682 cites W2214593749 @default.
- W2914954682 cites W2287275893 @default.
- W2914954682 cites W2321473418 @default.
- W2914954682 cites W2335497628 @default.
- W2914954682 cites W2472137319 @default.
- W2914954682 cites W3187773235 @default.
- W2914954682 cites W983370127 @default.
- W2914954682 doi "https://doi.org/10.1002/jor.24251" @default.
- W2914954682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30747438" @default.
- W2914954682 hasPublicationYear "2019" @default.
- W2914954682 type Work @default.
- W2914954682 sameAs 2914954682 @default.
- W2914954682 citedByCount "9" @default.
- W2914954682 countsByYear W29149546822019 @default.
- W2914954682 countsByYear W29149546822020 @default.
- W2914954682 countsByYear W29149546822021 @default.
- W2914954682 countsByYear W29149546822022 @default.
- W2914954682 countsByYear W29149546822023 @default.
- W2914954682 crossrefType "journal-article" @default.
- W2914954682 hasAuthorship W2914954682A5013726200 @default.
- W2914954682 hasAuthorship W2914954682A5021435173 @default.
- W2914954682 hasAuthorship W2914954682A5032141784 @default.
- W2914954682 hasAuthorship W2914954682A5040844384 @default.
- W2914954682 hasAuthorship W2914954682A5045563618 @default.
- W2914954682 hasAuthorship W2914954682A5067250316 @default.
- W2914954682 hasBestOaLocation W29149546821 @default.
- W2914954682 hasConcept C126322002 @default.
- W2914954682 hasConcept C141071460 @default.
- W2914954682 hasConcept C15490471 @default.
- W2914954682 hasConcept C15744967 @default.
- W2914954682 hasConcept C169760540 @default.
- W2914954682 hasConcept C170493617 @default.
- W2914954682 hasConcept C2775907655 @default.
- W2914954682 hasConcept C2779631646 @default.
- W2914954682 hasConcept C2780175798 @default.
- W2914954682 hasConcept C42219234 @default.
- W2914954682 hasConcept C44575665 @default.
- W2914954682 hasConcept C71924100 @default.
- W2914954682 hasConcept C94487597 @default.
- W2914954682 hasConceptScore W2914954682C126322002 @default.
- W2914954682 hasConceptScore W2914954682C141071460 @default.
- W2914954682 hasConceptScore W2914954682C15490471 @default.
- W2914954682 hasConceptScore W2914954682C15744967 @default.
- W2914954682 hasConceptScore W2914954682C169760540 @default.
- W2914954682 hasConceptScore W2914954682C170493617 @default.
- W2914954682 hasConceptScore W2914954682C2775907655 @default.
- W2914954682 hasConceptScore W2914954682C2779631646 @default.
- W2914954682 hasConceptScore W2914954682C2780175798 @default.
- W2914954682 hasConceptScore W2914954682C42219234 @default.