FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2914957908> ?p ?o ?g. }

• W2914957908 abstract "Due to the rising abuse of ketamine usage in recent years, ketamine‑induced urinary tract syndrome has received increasing attention. The present study aimed to investigate the molecular mechanism underlying ketamine‑associated cystitis in a mouse model. Female C57BL/6 mice were randomly divided into two groups: One group was treated with ketamine (100 mg/kg/day of ketamine for 20 weeks), whereas, the control group was treated with saline solution. In each group, micturition frequency and urine volume were examined to assess urinary voiding functions. Mouse bladders were extracted and samples were examined for pathological and morphological alterations using hematoxylin and eosin staining, Masson's trichrome staining and scanning electron microscopy. A cDNA microarray was conducted to investigate the differentially expressed genes following treatment with ketamine. The results suggested that bladder hyperactivity increased in the mice treated with ketamine. Furthermore, treatment with ketamine resulted in a smooth apical epithelial surface, subepithelial vascular congestion and lymphoplasmacytic aggregation. Microarray analysis identified a number of genes involved in extracellular matrix accumulation, which is associated with connective tissue fibrosis progression, and in calcium signaling regulation, that was associated with urinary bladder smooth muscle contraction. Collectively, the present results suggested that these differentially expressed genes may serve critical roles in ketamine‑induced alterations of micturition patterns and urothelial pathogenesis. Furthermore, the present findings may provide a theoretical basis for the development of effective therapies to treat ketamine‑induced urinary tract syndrome." @default.
• W2914957908 created "2019-02-21" @default.
• W2914957908 creator A5059487902 @default.
• W2914957908 creator A5071555183 @default.
• W2914957908 creator A5078788929 @default.
• W2914957908 creator A5079696640 @default.
• W2914957908 creator A5081214936 @default.
• W2914957908 creator A5084532597 @default.
• W2914957908 date "2019-01-29" @default.
• W2914957908 modified "2023-10-16" @default.
• W2914957908 title "Ketamine‑induced bladder dysfunction is associated with extracellular matrix accumulation and impairment of calcium signaling in a mouse model" @default.
• W2914957908 cites W132437762 @default.
• W2914957908 cites W1521791518 @default.
• W2914957908 cites W1537963116 @default.
• W2914957908 cites W15515072 @default.
• W2914957908 cites W1677563936 @default.
• W2914957908 cites W1884656506 @default.
• W2914957908 cites W1929411527 @default.
• W2914957908 cites W1973136410 @default.
• W2914957908 cites W1980325398 @default.
• W2914957908 cites W1980805930 @default.
• W2914957908 cites W2001306967 @default.
• W2914957908 cites W2005850081 @default.
• W2914957908 cites W2019370739 @default.
• W2914957908 cites W2022182637 @default.
• W2914957908 cites W2049286784 @default.
• W2914957908 cites W2050274654 @default.
• W2914957908 cites W2054880613 @default.
• W2914957908 cites W2058830397 @default.
• W2914957908 cites W2066655743 @default.
• W2914957908 cites W2071053637 @default.
• W2914957908 cites W2085548554 @default.
• W2914957908 cites W2094950759 @default.
• W2914957908 cites W2098037006 @default.
• W2914957908 cites W2101353144 @default.
• W2914957908 cites W2106765734 @default.
• W2914957908 cites W2107277218 @default.
• W2914957908 cites W2108331753 @default.
• W2914957908 cites W2108629686 @default.
• W2914957908 cites W2116889297 @default.
• W2914957908 cites W2122313401 @default.
• W2914957908 cites W2123588286 @default.
• W2914957908 cites W2138114150 @default.
• W2914957908 cites W2149431251 @default.
• W2914957908 cites W2150817857 @default.
• W2914957908 cites W2163389233 @default.
• W2914957908 cites W2166319310 @default.
• W2914957908 cites W2167148189 @default.
• W2914957908 cites W2169782879 @default.
• W2914957908 cites W2192080449 @default.
• W2914957908 cites W2288256636 @default.
• W2914957908 cites W2402854501 @default.
• W2914957908 cites W2472797536 @default.
• W2914957908 cites W2479410419 @default.
• W2914957908 cites W2559861360 @default.
• W2914957908 cites W2576066242 @default.
• W2914957908 cites W2590739844 @default.
• W2914957908 cites W2599256654 @default.
• W2914957908 cites W2745286794 @default.
• W2914957908 cites W2746805291 @default.
• W2914957908 cites W2794188102 @default.
• W2914957908 cites W797317773 @default.
• W2914957908 doi "https://doi.org/10.3892/mmr.2019.9907" @default.
• W2914957908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6423593" @default.
• W2914957908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30720140" @default.
• W2914957908 hasPublicationYear "2019" @default.
• W2914957908 type Work @default.
• W2914957908 sameAs 2914957908 @default.
• W2914957908 citedByCount "6" @default.
• W2914957908 countsByYear W29149579082019 @default.
• W2914957908 countsByYear W29149579082021 @default.
• W2914957908 countsByYear W29149579082022 @default.
• W2914957908 crossrefType "journal-article" @default.
• W2914957908 hasAuthorship W2914957908A5059487902 @default.
• W2914957908 hasAuthorship W2914957908A5071555183 @default.
• W2914957908 hasAuthorship W2914957908A5078788929 @default.
• W2914957908 hasAuthorship W2914957908A5079696640 @default.
• W2914957908 hasAuthorship W2914957908A5081214936 @default.
• W2914957908 hasAuthorship W2914957908A5084532597 @default.
• W2914957908 hasBestOaLocation W29149579081 @default.
• W2914957908 hasConcept C121608353 @default.
• W2914957908 hasConcept C125473707 @default.
• W2914957908 hasConcept C126322002 @default.
• W2914957908 hasConcept C134018914 @default.
• W2914957908 hasConcept C142724271 @default.
• W2914957908 hasConcept C175768497 @default.
• W2914957908 hasConcept C189165786 @default.
• W2914957908 hasConcept C2776235491 @default.
• W2914957908 hasConcept C2779478474 @default.
• W2914957908 hasConcept C2779762690 @default.
• W2914957908 hasConcept C2780795376 @default.
• W2914957908 hasConcept C2780942790 @default.
• W2914957908 hasConcept C42219234 @default.
• W2914957908 hasConcept C71924100 @default.
• W2914957908 hasConcept C74864618 @default.
• W2914957908 hasConcept C77411442 @default.
• W2914957908 hasConcept C86803240 @default.
• W2914957908 hasConcept C95444343 @default.
• W2914957908 hasConceptScore W2914957908C121608353 @default.
• W2914957908 hasConceptScore W2914957908C125473707 @default.

• next